The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution DOI Open Access
Alyssa Lyn Fortier, Jonathan K. Pritchard

Опубликована: Янв. 13, 2025

Gene families are groups of evolutionarily-related genes. One large gene family that has experienced rapid evolution is the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity. Across ∼60 million year history primates, some MHC genes have turned over completely, changed function, converged others remained essentially unchanged. Past work typically focused on identifying alleles within particular species or comparing content, but more needed to understand overall across species. Thus, despite immunologic importance its peculiar evolutionary history, we lack a complete picture primates. We readdress this question using sequences from dozens pseudogenes spanning entire primate order, building comprehensive set allele trees with modern methods. Overall, find Class I subfamily evolving much quickly than II subfamily, exception MHC-DRB also pay special attention often-ignored pseudogenes, which use reconstruct different events region. shared function species, employ genes, haplotypes, patterns variation achieve successful immune response. Our extensive literature review represent most look into date.

Язык: Английский

The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution DOI Open Access
Alyssa Lyn Fortier, Jonathan K. Pritchard

Опубликована: Янв. 13, 2025

Gene families are groups of evolutionarily-related genes. One large gene family that has experienced rapid evolution is the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity. Across ∼60 million year history primates, some MHC genes have turned over completely, changed function, converged others remained essentially unchanged. Past work typically focused on identifying alleles within particular species or comparing content, but more needed to understand overall across species. Thus, despite immunologic importance its peculiar evolutionary history, we lack a complete picture primates. We readdress this question using sequences from dozens pseudogenes spanning entire primate order, building comprehensive set allele trees with modern methods. Overall, find Class I subfamily evolving much quickly than II subfamily, exception MHC-DRB also pay special attention often-ignored pseudogenes, which use reconstruct different events region. shared function species, employ genes, haplotypes, patterns variation achieve successful immune response. Our extensive literature review represent most look into date.

Язык: Английский

Процитировано

0
The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution DOI Open Access
Alyssa Lyn Fortier, Jonathan K. Pritchard

Опубликована: Янв. 13, 2025

Gene families are groups of evolutionarily-related genes. One large gene family that has experienced rapid evolution is the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity. Across ∼60 million year history primates, some MHC genes have turned over completely, changed function, converged others remained essentially unchanged. Past work typically focused on identifying alleles within particular species or comparing content, but more needed to understand overall across species. Thus, despite immunologic importance its peculiar evolutionary history, we lack a complete picture primates. We readdress this question using sequences from dozens pseudogenes spanning entire primate order, building comprehensive set allele trees with modern methods. Overall, find Class I subfamily evolving much quickly than II subfamily, exception MHC-DRB also pay special attention often-ignored pseudogenes, which use reconstruct different events region. shared function species, employ genes, haplotypes, patterns variation achieve successful immune response. Our extensive literature review represent most look into date.

Язык: Английский

Процитировано

0