The
budding
yeast
Saccharomyces
cerevisiae
is
a
long-standing
model
for
the
three-dimensional
organization
of
eukaryotic
genomes.
However,
even
in
this
well-studied
model,
it
unclear
how
homolog
pairing
diploids
or
environmental
conditions
influence
overall
genome
organization.
Here,
we
performed
high-throughput
chromosome
conformation
capture
on
diverged
hybrid
to
obtain
first
global
view
diploid
yeasts.
After
controlling
Rabl-like
orientation
using
polymer
observe
significant
proximity
that
increases
saturated
culture
conditions.
Surprisingly,
localized
increase
homologous
interactions
between
HAS1-TDA1
alleles
specifically
under
galactose
induction
and
growth.
This
accompanied
by
relocalization
nuclear
periphery
requires
Nup2,
suggesting
role
pore
complexes.
Together,
these
results
reveal
has
dynamic
complex
3D
Plants
frequently
have
to
weather
both
biotic
and
abiotic
stressors,
evolved
sophisticated
adaptation
defense
mechanisms.
In
recent
years,
chromatin
modifications,
nucleosome
positioning,
DNA
methylation
been
recognized
as
important
components
in
these
adaptations.
Given
their
potential
epigenetic
nature,
such
modifications
may
provide
a
mechanistic
basis
for
stress
memory,
enabling
plants
respond
more
efficiently
recurring
or
even
prepare
offspring
future
assaults.
this
review,
we
discuss
the
involvement
of
responses
current
evidence
on
somatic,
intergenerational,
transgenerational
memory.
Proceedings of the National Academy of Sciences,
Год журнала:
2019,
Номер
117(38), С. 23280 - 23285
Опубликована: Авг. 9, 2019
Significance
Prenatal
stress
exposure
is
associated
with
a
wide
range
of
health
problems
later
in
life.
This
may
be
mediated
part
via
glucocorticoid
(GC)
during
fetal
development
known
to
impact
neurogenesis
and
induce
epigenetic
changes.
Using
human
hippocampal
progenitor
cell
line
assess
the
effects
GCs,
we
observe
that
GCs
early
results
lasting
changes
DNA
methylation
(DNAm).
Lasting
DNAm
alterations
are
significantly
enhanced
transcriptional
response
subsequent
GC
exposure.
Our
data
suggest
set
point
future
responses
by
inducing
Such
altered
points
relate
differential
vulnerability
Epigenetics & Chromatin,
Год журнала:
2019,
Номер
12(1)
Опубликована: Янв. 7, 2019
Epigenetic
modifications
such
as
histone
methylation
permit
change
in
chromatin
structure
without
accompanying
the
underlying
genomic
sequence.
A
number
of
studies
animal
models
have
shown
that
dysregulation
various
components
epigenetic
machinery
causes
cognitive
deficits
at
behavioral
level,
suggesting
proper
control
is
necessary
for
fundamental
processes
learning
and
memory.
Histone
H3
lysine
K4
(H3K4)
comprises
one
component
control,
global
levels
this
mark
are
increased
hippocampus
during
memory
formation.
Modifiers
H3K4
needed
formation,
through
studies,
many
same
modifiers
mutated
human
diseases.
Indeed,
all
known
methyltransferases
four
six
demethylases
been
associated
with
impaired
cognition
a
neurologic
or
psychiatric
disorder.
Cognitive
impairment
patients
often
manifests
intellectual
disability,
consistent
role
As
modification
quintessentially,
but
not
exclusively,
transcriptional
activity,
provides
unique
insights
into
regulatory
complexity
writing,
reading,
erasing
marks
within
an
activated
neuron.
The
following
review
will
discuss
connect
it
to
events
required
developed
nervous
system.
This
include
initial
discussion
most
recent
advances
developing
methodology
analyze
methylation,
namely
mass
spectrometry
deep
sequencing,
well
how
these
methods
can
be
applied
more
deeply
understand
biology
brain.
We
then
introduce
core
enzymatic
mediating
addition
removal
resulting
signatures
throughout
neuronal
genome.
next
foray
brain,
discussing
changes
formation
retrieval,
correlates
methyltransferase
deficiency
region.
Finally,
we
diseases
connected
each
modulator
summarize
drugs
target
them.
Current Opinion in Plant Biology,
Год журнала:
2021,
Номер
61, С. 102007 - 102007
Опубликована: Фев. 9, 2021
As
sessile
organisms,
plants
have
evolved
sophisticated
ways
to
constantly
gauge
and
adapt
changing
environmental
conditions
including
extremes
that
may
be
harmful
their
growth
development
are
thus
perceived
as
stress.
In
nature,
stressful
events
often
chronic
or
recurring
an
initial
stress
prime
a
plant
respond
more
efficiently
subsequent
event.
An
epigenetic
basis
of
such
memory
was
long
postulated
in
recent
years
it
has
been
shown
this
is
indeed
the
case.
High
temperature
proven
excellent
system
unpick
molecular
somatic
memory,
which
includes
histone
modifications
nucleosome
occupancy.
This
review
discusses
findings
pinpoints
open
questions
field.
New Phytologist,
Год журнала:
2022,
Номер
234(4), С. 1144 - 1160
Опубликована: Янв. 17, 2022
Summary
Many
environmental
conditions
fluctuate
and
organisms
need
to
respond
effectively.
This
is
especially
true
for
temperature
cues
that
can
change
in
minutes
seasons
often
follow
a
diurnal
rhythm.
Plants
cannot
migrate
most
regulate
their
temperature.
Therefore,
broad
array
of
responses
have
evolved
deal
with
from
freezing
heat
stress.
A
particular
response
mildly
elevated
temperatures
called
thermomorphogenesis,
suite
morphological
adaptations
includes
thermonasty,
formation
thin
leaves
elongation
growth
petioles
hypocotyl.
Thermomorphogenesis
allows
optimal
performance
suboptimal
by
enhancing
the
cooling
capacity.
When
rise
further,
stress
tolerance
mechanisms
be
induced
enable
plant
survive
stressful
temperature,
which
typically
comprises
cellular
protection
memory
thereof.
Induction
depend
on
gene
expression
regulation,
governed
diverse
epigenetic
processes.
In
this
Tansley
review
we
update
current
knowledge
regulation
signalling
response,
focus
thermomorphogenesis
memory.
highlight
emerging
role
H3K4
methylation
marks
pathways.