Spontaneous
brain
activity,
typically
investigated
using
resting-state
fMRI
(rsfMRI),
provides
a
measure
of
inter-areal
functional
connectivity
(RSFC).
Although
it
has
been
established
that
RSFC
is
non-stationary,
previous
dynamic
rsfMRI
studies
mainly
focused
on
revealing
the
spatial
characteristics
patterns,
but
temporal
relationship
between
these
patterns
remains
elusive.
Here
we
organization
characteristic
in
awake
rats
and
humans.
We
found
transitions
were
not
random
followed
specific
sequential
orders.
The
pattern
was
further
analyzed
graph
theory,
pivotal
identified.
This
study
demonstrated
spontaneous
activity
only
nonrandom
spatially,
also
temporally,
this
feature
well
conserved
rodents
These
results
offer
new
insights
into
understanding
spatiotemporal
dynamics
mammalian
brain.
Neuron,
Год журнала:
2017,
Номер
94(4), С. 891 - 907.e6
Опубликована: Май 1, 2017
The
successful
planning
and
execution
of
adaptive
behaviors
in
mammals
may
require
long-range
coordination
neural
networks
throughout
cerebral
cortex.
neuronal
implementation
signals
that
could
orchestrate
cortex-wide
activity
remains
unclear.
Here,
we
develop
apply
methods
for
Ca2+
imaging
mice
performing
decision-making
behavior
identify
a
global
cortical
representation
task
engagement
encoded
the
dynamics
both
single
cells
superficial
neuropil
distributed
across
majority
dorsal
multiple
molecularly
defined
cell
types
was
found
to
reflect
this
with
type-specific
dynamics.
Focal
optogenetic
inhibition
tiled
cortex
revealed
crucial
role
frontal
triggering
phenomenon;
local
region
blocked
response
task-initiating
cues
voluntary
behavior.
These
findings
reveal
cell-type-specific
processes
globally
representing
goal-directed
major
node
gates
broadcast
task-related
information.
Trends in Neurosciences,
Год журнала:
2023,
Номер
46(7), С. 508 - 524
Опубликована: Май 8, 2023
The
rapid
and
coordinated
propagation
of
neural
activity
across
the
brain
provides
foundation
for
complex
behavior
cognition.
Technical
advances
neuroscience
subfields
have
advanced
understanding
these
dynamics,
but
points
convergence
are
often
obscured
by
semantic
differences,
creating
silos
subfield-specific
findings.
In
this
review
we
describe
how
a
parsimonious
conceptualization
state
as
fundamental
building
block
whole-brain
offers
common
framework
to
relate
findings
scales
species.
We
present
examples
diverse
techniques
commonly
used
study
states
associated
with
physiology
higher-order
cognitive
processes,
discuss
integration
them
will
enable
more
comprehensive
mechanistic
characterization
dynamics
that
crucial
survival
disrupted
in
disease.
Journal of Neuroscience,
Год журнала:
2017,
Номер
37(31), С. 7513 - 7533
Опубликована: Июль 3, 2017
Connectivity
mapping
based
on
resting-state
activity
in
mice
has
revealed
functional
motifs
of
correlated
activity.
However,
the
rules
by
which
organize
into
larger
modules
that
lead
to
hemisphere
wide
spatial-temporal
sequences
is
not
clear.
We
explore
cortical
parcellation
head-fixed,
quiet
awake
GCaMP6
from
both
sexes
using
mesoscopic
calcium
imaging.
Spectral
decomposition
spontaneous
presence
two
dominant
frequency
modes
(<1
and
∼3
Hz),
each
them
associated
with
a
unique
spatial
signature
macro-parcellation
predicted
classical
cytoarchitectonic
definitions
areas.
Based
assessment
0.1–1
Hz
activity,
we
define
macro-organizing
principles:
first
being
rotating
polymodal-association
pinwheel
structure
around
flows
sequentially
visual
barrel
then
hindlimb
somatosensory;
second
principle
symmetry
planes
exist
many
levels
within
single
domain
such
as
intrahemispheric
reflections
sensory
motor
cortices.
In
contrast,
higher
>1
yielded
clusters
coactivated
areas
an
enlarged
default
mode
network-like
posterior
region.
suggest
apparent
constrained
for
intra-areal
flow
could
be
exploited
future
efforts
normalize
diseases
nervous
system.
SIGNIFICANCE
STATEMENT
Increasingly,
connectivity
used
reveal
organization
brain.
because
brain
operates
across
multiple
space
time
domains
more
detailed
understanding
this
necessary.
in
vivo
wide-field
imaging
indicator
characterize
at
different
spatiotemporal
scales.
Correlation
analysis
defines
three
superclusters
span
traditionally
defined
territories
were
dependent.
This
work
helps
how
interact
space.
provide
framework
necessary
studies
reorganization
circuits
disease
models.
Current Biology,
Год журнала:
2019,
Номер
29(14), С. 2295 - 2306.e5
Опубликована: Июль 1, 2019
Spontaneous
brain
activity
as
assessed
with
resting-state
fMRI
exhibits
rich
spatiotemporal
structure.
However,
the
principles
by
which
brain-wide
patterns
of
spontaneous
reconfigure
and
interact
each
other
remain
unclear.
We
used
a
framewise
clustering
approach
to
map
dynamics
voxel
resolution
in
resting
mouse
brain.
show
that
co-activation
can
be
reliably
mapped
at
group
subject
level,
defining
restricted
set
recurring
states
characterized
network
Importantly,
we
document
identified
exhibit
contrasting
functional
coupled
infraslow
dynamics,
state
occurring
specific
phases
global
signal
fluctuations.
Finally,
autism-associated
genetic
alterations
entail
engagement
atypical
altered
dynamics.
Our
results
reveal
novel
fundamental
guiding
organization
its
disruption
disorders.
