Dopamine modulation of sensory processing and adaptive behavior in flies DOI Creative Commons

K.P. Siju,

Jean‐François De Backer, Ilona C Grunwald Kadow

и другие.

Cell and Tissue Research, Год журнала: 2021, Номер 383(1), С. 207 - 225

Опубликована: Янв. 1, 2021

Abstract Behavioral flexibility for appropriate action selection is an advantage when animals are faced with decisions that will determine their survival or death. In order to arrive at the right decision, evaluate information from external environment, internal state, and past experiences. How these different signals integrated modulated in brain, how context- state-dependent behavioral controlled poorly understood questions. Studying molecules help convey integrate such neural circuits important way approach Many years of work model organisms have shown dopamine a critical neuromodulator (reward based) associative learning. However, recent findings vertebrates invertebrates demonstrated complexity heterogeneity dopaminergic neuron populations functional implications many adaptive behaviors survival. For example, neurons can sensory information, states, learned experience decision making circuitry. Several advances methodologies availability synaptic level connectome whole-brain circuitry Drosophila melanogaster make fly attractive system study roles behavior. particular, learning memory center—the mushroom body—is richly innervated by enable it multi-modal according state context, modulate decision-making

Язык: Английский

The connectome of the adult Drosophila mushroom body provides insights into function DOI Creative Commons
Feng Li, Jack Lindsey, Elizabeth C. Marin

и другие.

eLife, Год журнала: 2020, Номер 9

Опубликована: Дек. 14, 2020

Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with direct connections descending neurons. We find unexpected structure sensory inputs, transfer information different modalities MBONs, modulation that dopaminergic (DANs). provide insights into circuitry used integrate outputs, between central complex inputs DANs, feedback MBONs. Our results a foundation further theoretical work.

Язык: Английский

Процитировано

347
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior DOI
Dick R. Nässel, Meet Zandawala

Progress in Neurobiology, Год журнала: 2019, Номер 179, С. 101607 - 101607

Опубликована: Март 22, 2019

Язык: Английский

Процитировано

307
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit DOI
Mehrab N Modi, Yichun Shuai, Glenn Turner

и другие.

Annual Review of Neuroscience, Год журнала: 2020, Номер 43(1), С. 465 - 484

Опубликована: Апрель 14, 2020

The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations, yet it achieves many operations common across memory systems. Recent advances have established clear framework learning and revealed the following key operations: a) pattern separation, whereby dense combinatorial representations of odors are preprocessed to generate highly specific, nonoverlapping odor patterns used learning; b) convergence, in which sensory information is funneled small set output neurons that guide behavioral actions; c) plasticity, where changing mapping input requires strong reinforcement signal, also modulated by internal state environmental context; d) modularization, consists multiple parallel traces, distinct stability flexibility exist anatomically well-defined modules within network. Cross-module interactions allow higher-order effects past experience influences future learning. Many these parallels with processes formation action selection more complex brains.

Язык: Английский

Процитировано

172
The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

и другие.

Neuron, Год журнала: 2022, Номер 110(16), С. 2545 - 2570

Опубликована: Май 27, 2022

Язык: Английский

Процитировано

142
Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies DOI Creative Commons

Efrén Álvarez-Salvado,

Angela Licata,

Erin Connor

и другие.

eLife, Год журнала: 2018, Номер 7

Опубликована: Авг. 21, 2018

Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function behavior, but the algorithms underlying are unclear. Here, we develop a high-throughput assay measure olfactory behavior response well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during (ON response), and local search at offset (OFF response). Wind orientation requires antennal mechanoreceptors, driven solely by odor. Using dynamic stimuli, dependence of these behaviors on intensity history. Based data, navigation model recapitulates flies our apparatus, generates realistic trajectories when turbulent boundary layer plume. The ability parse into quantifiable elementary sensori-motor transformations provides foundation for dissecting circuits govern behavior.

Язык: Английский

Процитировано

135
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila DOI Creative Commons
Sercan Sayın, Jean‐François De Backer,

K.P. Siju

и другие.

Neuron, Год журнала: 2019, Номер 104(3), С. 544 - 558.e6

Опубликована: Авг. 27, 2019

In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion fear. How need motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that flies persistently track food odor increase their effort over repeated trials in absence reward suggesting dominates negative experience. We further tracking regulated by two mushroom body output neurons (MBONs) connecting MB lateral horn. These MBONs, together with dopaminergic Dop1R2 signaling, behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one acts as brake on feeding olfaction. Together, our data suggest function for internal state-dependent expression can be suppressed external inputs conveying competing drive.

Язык: Английский

Процитировано

127
Neural basis of hunger-driven behaviour in Drosophila DOI Creative Commons
Suewei Lin,

Bhagyashree Senapati,

Chang-Hui Tsao

и другие.

Open Biology, Год журнала: 2019, Номер 9(3)

Опубликована: Март 1, 2019

Hunger is a motivational state that drives eating and food-seeking behaviour. In psychological sense, hunger sets the goal guides an animal in pursuit of food. The biological basis underlying this purposive, goal-directed nature has been under intense investigation. With its rich behavioural repertoire genetically tractable nervous system, fruit fly Drosophila melanogaster emerged as excellent model system for studying neural hunger-driven Here, we review our current understanding how sensed, encoded translated into foraging feeding behaviours fly.

Язык: Английский

Процитировано

117
A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila DOI

Bhagyashree Senapati,

Chang-Hui Tsao,

Yi-An Juan

и другие.

Nature Neuroscience, Год журнала: 2019, Номер 22(12), С. 2029 - 2039

Опубликована: Окт. 28, 2019

Язык: Английский

Процитировано

90
Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions DOI Creative Commons
Dick R. Nässel, Meet Zandawala

Cell and Tissue Research, Год журнала: 2020, Номер 382(2), С. 233 - 266

Опубликована: Авг. 22, 2020

Hormones regulate development, as well many vital processes in the daily life of an animal. Many these hormones are peptides that act at a higher hierarchical level animal with roles organizers globally orchestrate metabolism, physiology and behavior. Peptide can on multiple peripheral targets simultaneously convey basal states, such metabolic status sleep-awake or arousal across central neuronal circuits. Thereby, they coordinate responses to changing internal external environments. The activity neurosecretory cells is controlled either by (1) cell autonomous sensors, (2) other neurons relay signals from sensors tissues (3) feedback target cells. Thus, hormonal signaling axis commonly comprises several components. In mammals vertebrates, axes known, hypothalamic-pituitary-gonad hypothalamic-pituitary-thyroid reproduction respectively. It has been proposed basic organization evolutionarily old cellular homologs hypothalamic-pituitary system be found for instance insects. To obtain appreciation similarities between insect vertebrate axes, we review systems Drosophila. Our outlines major peptidergic pathways known Drosophila presents set schemes orchestrating systems. detailed larval adult displays only very those arthropods vertebrates.

Язык: Английский

Процитировано

89
Valence and State-Dependent Population Coding in Dopaminergic Neurons in the Fly Mushroom Body DOI Creative Commons

K.P. Siju,

Vilim Štih, Sophie Aimon

и другие.

Current Biology, Год журнала: 2020, Номер 30(11), С. 2104 - 2115.e4

Опубликована: Май 7, 2020

Neuromodulation permits flexibility of synapses, neural circuits, and ultimately behavior. One neuromodulator, dopamine, has been studied extensively in its role as a reward signal during learning memory across animal species. Newer evidence suggests that dopaminergic neurons (DANs) can modulate sensory perception acutely, thereby allowing an to adapt behavior decision making internal behavioral state. In addition, some data indicate DANs are not homogeneous but rather convey different types information heterogeneous population. We have investigated DAN population activity how it could encode relevant about stimuli state by taking advantage the confined anatomy innervating mushroom body (MB) fly Drosophila melanogaster. Using vivo calcium imaging custom 3D image registration method, we found MB encodes innate valence odor or taste well physiological animal. Furthermore, is strongly correlated with movement, consistent dopamine conveying MB. Altogether, our analysis suggest activities valence, MB-compartment-specific manner. propose shapes through combinatorial coding physiological, context.

Язык: Английский

Процитировано

77