Odour motion sensing enhances navigation of complex plumes

Nature, Год журнала: 2022, Номер 611(7937), С. 754 - 761

Опубликована: Ноя. 9, 2022

Язык: Английский

---

Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

eLife, Год журнала: 2023, Номер 12

Опубликована: Янв. 24, 2023

Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify feedforward circuit formed between dopamine show that essential for second-order conditioning, an ethologically important form of higher-order associative The Drosophila mushroom body comprises series dopaminergic compartments, each which exhibits dynamics. We find slow stable compartment can serve as effective ‘teacher’ by instructing other faster transient compartments via single key interneuron, connectome analysis neurotransmitter prediction. This excitatory interneuron acquires enhanced response to reward-predicting odor after first-order conditioning and, upon activation, evokes release the ‘student’ compartments. These hierarchical connections explain first- long known behavioral psychologists.

Язык: Английский

---

Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

eLife, Год журнала: 2023, Номер 12

Опубликована: Сен. 18, 2023

How memories are used by the brain to guide future action is poorly understood. In olfactory associative learning in Drosophila, multiple compartments of mushroom body act parallel assign a valence stimulus. Here, we show that appetitive stored different induce levels upwind locomotion. Using photoactivation screen new collection split-GAL4 drivers and EM connectomics, identified cluster neurons postsynaptic output (MBONs) can trigger robust steering. These UpWind Neurons (UpWiNs) integrate inhibitory excitatory synaptic inputs from MBONs aversive memory compartments, respectively. After formation memory, UpWiNs acquire enhanced response reward-predicting odors as presynaptic MBON undergoes depression. Blocking impaired reduced locomotion during retrieval. Photoactivation also increased chance returning location where activation was terminated, suggesting an additional role navigation. Thus, our results provide insight into how learned abstract valences gradually transformed concrete memory-driven actions through divergent convergent networks, neuronal architecture commonly found vertebrate invertebrate brains.

Язык: Английский

---

Olfactory navigation in arthropods

Journal of Comparative Physiology A, Год журнала: 2023, Номер 209(4), С. 467 - 488

Опубликована: Янв. 20, 2023

Abstract Using odors to find food and mates is one of the most ancient highly conserved behaviors. Arthropods from flies moths crabs use broadly similar strategies navigate toward odor sources—such as integrating flow information with information, comparing concentration across sensors, over time. Because arthropods share many homologous brain structures—antennal lobes for processing olfactory mechanosensors flow, mushroom bodies (or hemi-ellipsoid bodies) associative learning, central complexes navigation, it likely that these closely related behaviors are mediated by neural circuits. However, differences in types they seek, physics dispersal, locomotion water, air, on substrates mean circuits must have adapted generate a wide diversity odor-seeking In this review, we discuss common specializations observed navigation behavior arthropods, review our current knowledge about subserving behavior. We propose comparative study arthropod nervous systems may provide insight into how set basic circuit structures has diversified different environments.

Язык: Английский

---

The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila

Current Biology, Год журнала: 2024, Номер 34(3), С. 473 - 488.e6

Опубликована: Янв. 4, 2024

Complex behaviors depend on the precise developmental specification of neuronal circuits, but relationship between genetic programs for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) a conserved sensory-motor integration center in insects, which governs many higher-order largely derives from small number type II stem cells (NSCs). Here, we show that Imp, IGF-II mRNA-binding protein expressed NSCs, plays role specifying essential components CX olfactory navigation circuitry. We following: (1) multiple circuitry arise NSCs. (2) Manipulating Imp expression NSCs alters morphology these elements, with most potent effects neurons targeting ventral layers fan-shaped body (FB). (3) regulates Tachykinin-expressing FB input neurons. (4) required establishing proper neuropil structures. (5) Loss abolishes upwind orientation to attractive odor while leaving locomotion odor-evoked regulation movement intact. Taken together, our findings establish temporally gene can regulate behavior by developmentally regulating provides first step toward dissection its roles behavior.

Язык: Английский

---

Wind gates olfaction-driven search states in free flight

Current Biology, Год журнала: 2024, Номер 34(19), С. 4397 - 4411.e6

Опубликована: Июль 26, 2024

Язык: Английский

---

Q-learning with temporal memory to navigate turbulence

Опубликована: Март 5, 2025

We consider the problem of olfactory searches in a turbulent environment. focus on agents that respond solely to odor stimuli, with no access spatial perception nor prior information about odor. ask whether navigation target can be learned robustly within sequential decision making framework. develop reinforcement learning algorithm using small set interpretable states and train it realistic cues. By introducing temporal memory, we demonstrate two salient features traces, discretized few states, are sufficient learn plume. Performance is dictated by sparse nature odors. An optimal memory exists which ignores blanks plume activates recovery strategy outside obtain best performance letting their show mostly casting cross wind, similar behavior observed flying insects. The robust substantial changes plumes, suggesting minor parameter tuning may adapt different environments.

Язык: Английский

---

Sensorimotor pathway controlling stopping behavior during chemotaxis in the Drosophila melanogaster larva

eLife, Год журнала: 2018, Номер 7

Опубликована: Ноя. 22, 2018

Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, detection of positive odor gradients extends runs while negative promote stops and turns. This algorithm represents a foundation for control sensory across phyla. In present work, we identified an olfactory descending neuron, PDM-DN, which plays pivotal role organization turns response to graded changes concentrations. Artificial activation this neuron induces deterministic followed by initiation turning maneuvers through head casts. Using electron microscopy, reconstructed main pathway that connects PDM-DN peripheral system pre-motor circuit responsible actuation forward peristalsis. Our set stage detailed mechanistic analysis sensorimotor conversion inputs into action selection perform goal-oriented navigation.

Язык: Английский

---

Visually Guided Behavior and Optogenetically Induced Learning in Head-Fixed Flies Exploring a Virtual Landscape

Current Biology, Год журнала: 2019, Номер 29(10), С. 1647 - 1659.e8

Опубликована: Май 1, 2019

Studying the intertwined roles of sensation, experience, and directed action in navigation has been facilitated by development virtual reality (VR) environments for head-fixed animals, allowing quantitative measurements behavior well-controlled conditions. VR long featured studies Drosophila melanogaster, but these experiments have typically allowed fly to change only its heading a visual scene not position. Here we explore how flies move two dimensions (2D) using environment that more closely captures an animal's experience during free behavior. We show flies' 2D interaction with landmarks cannot be automatically derived from their orienting under simpler one-dimensional (1D) Using novel paradigms, then demonstrate adapt response optogenetically delivered appetitive aversive stimuli. Much like free-walking after encounters food, exploring respond optogenetic activation sugar-sensing neurons initiating local search, which appears rely on landmarks. Visual can, however, help avoid areas where they aversive, generated heat stimulus. By coupling presence near specific shapes, elicit selective learned avoidance those Thus, adaptively navigate environments, reliance is context dependent. These behavioral paradigms set stage interrogation brain circuitry underlying flexible complex multisensory environments.

Язык: Английский

---

Diverse Food-Sensing Neurons Trigger Idiothetic Local Search in Drosophila

Current Biology, Год журнала: 2019, Номер 29(10), С. 1660 - 1668.e4

Опубликована: Май 1, 2019

Язык: Английский

---