Preventing the return of fear in humans using reconsolidation update mechanisms: A verification report of Schiller et al. (2010)

Cortex, Год журнала: 2020, Номер 129, С. 510 - 525

Опубликована: Июнь 18, 2020

Язык: Английский

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Measuring fear: Association among different measures of fear learning.

Journal of Behavior Therapy and Experimental Psychiatry, Год журнала: 2020, Номер 70, С. 101618 - 101618

Опубликована: Сен. 23, 2020

Fear conditioning paradigms use various measures to assess learned fear, including autonomic arousal responses like skin conductance, and self-reports of both associative (US-expectancies) evaluative (affective ratings) learning. The present study uses a dimensional approach examine associations among fear indices directly. Seventy-three participants completed differential experiment, during which neutral stimulus (CS+) was paired with an electric shock (US), while another (CS-) never the (partially instructed acquisition). Ten minutes later, stimuli were presented without any shocks (fear extinction). Skin conductance US-expectancy ratings recorded each phase, self-reported negative affect assessed for CS at end extinction. Results showed positive association acquisition early overall extinction positively associated post-extinction affect. lack affective post-acquisition may have obscured between learning indices. provide evidence expected correspondence different Findings emphasize need incorporating in paradigms.

Язык: Английский

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Calibrating the experimental measurement of psychological attributes

Nature Human Behaviour, Год журнала: 2020, Номер 4(12), С. 1229 - 1235

Опубликована: Ноя. 16, 2020

Язык: Английский

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A ventral striatal prediction error signal in human fear extinction learning

NeuroImage, Год журнала: 2021, Номер 229, С. 117709 - 117709

Опубликована: Янв. 15, 2021

Animal studies have shown that the prediction error (PE) signal drives fear extinction learning is encoded by phasic activity of midbrain dopamine (DA) neurons. Thus, PE resembles appetitive reward learning. In humans, less well understood. Using computational neuroimaging, a previous study from our group reported hemodynamic in left ventral putamen, subregion striatum (VS), to correlate with function derived formal associative model. The was modulated genetic variation DA-related gene. To conceptually replicate and extend this finding, we here asked whether an (EPE) putamen can also be observed when genotype information not taken into account. optimized experimental design for model estimation, again EPE-related same striatal region, indicating activation region feature human We further significant EPE signals across wider parts VS as frontal cortical areas. These results may suggest errors during are available larger brain, has been neuroimaging signaling. Conclusive evidence DAergic nature still outstanding.

Язык: Английский

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Safety learning and the Pavlovian conditioned inhibition of fear in humans: Current state and future directions

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 127, С. 659 - 674

Опубликована: Май 20, 2021

Язык: Английский

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