Resource scarcity but not maternal separation provokes unpredictable maternal care sequences in mice and both upregulate Crh-associated gene expression in the amygdala DOI Creative Commons
Camila Demaestri, Meghan Gallo,

Elisa Mazenod

и другие.

Neurobiology of Stress, Год журнала: 2022, Номер 20, С. 100484 - 100484

Опубликована: Сен. 1, 2022

Early life adversity (ELA) is a major risk factor for the development of pathology, including anxiety disorders. Neurodevelopmental and behavioral outcomes following ELA are multifaceted influenced heavily by type experienced sex individual experiencing ELA. It remains unclear what properties portend differential neurobiological basis sex-differences negative outcomes. Predictability postnatal environment has emerged as being core feature supporting development, with most salient signals deriving from parental care. care may be distinguishing different forms ELA, degree predictability afforded these manipulations contribute to diversity observed across models. Further, questions remain whether differing levels effects on neurodevelopment expression genes associated pathology. Here, we tested hypothesis that changes in maternal behavior mice would contingent experienced, directly comparing limited bedding nesting (LBN) separation (MS) paradigms. We then altered corticotropin-releasing hormone (Crh), sexually-dimorphic neuropeptide regulates threat-related learning, amygdala male female mice. The LBN manipulation reliably increased entropy care, measure indicates lower between sequences dam behavior. MS rearing similarly frequency nest sorties licking pups but had mixed other aspects dam-, pup-, nest-related behaviors. Increased Crh-related was gene measures showing significant interaction manipulation. Specifically, males, not females, primarily males. present study provides evidence models demonstrates robust consequences experience critically stress responding differences

Язык: Английский

The Hidden Talents Framework DOI Open Access
Bruce J. Ellis, Laura S. Abrams, Ann S. Masten

и другие.

Опубликована: Март 24, 2023

Although early-life adversity can undermine healthy development, an evolutionary-developmental perspective implies that children growing up in harsh environments will develop intact, or even enhanced, skills for solving problems high‐adversity contexts (i.e., 'hidden talents'). This Element situates the hidden talents model within a larger interdisciplinary framework. Summarizing theory and research on talents, it proposes stress-adapted represent form of adaptive intelligence enabling individuals to function constraints environments. It discusses potential applications this multiple sectors concerned with youth from environments, including education, social services, juvenile justice, compares contemporary developmental resilience models. The approach, concludes, offers exciting directions childhood adversity, translational implications leveraging more effectively tailor jobs, interventions fit needs diverse range life circumstances.

Язык: Английский

Процитировано

15
Sex differences in the rodent medial prefrontal cortex – What Do and Don't we know? DOI
Mikaela A. Laine, Eliza M. Greiner, Rebecca M. Shansky

и другие.

Neuropharmacology, Год журнала: 2024, Номер 248, С. 109867 - 109867

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

6
How Early Life Adversity Influences Defensive Circuitry DOI
Sahana Murthy, Elizabeth Gould

Trends in Neurosciences, Год журнала: 2020, Номер 43(4), С. 200 - 212

Опубликована: Март 6, 2020

Язык: Английский

Процитировано

35
Region-specific effects of maternal separation on oxidative stress accumulation in parvalbumin neurons of male and female rats DOI
Alexa R. Soares, Kelsea R. Gildawie, Jennifer A. Honeycutt

и другие.

Behavioural Brain Research, Год журнала: 2020, Номер 388, С. 112658 - 112658

Опубликована: Апрель 24, 2020

Язык: Английский

Процитировано

33
Resource scarcity but not maternal separation provokes unpredictable maternal care sequences in mice and both upregulate Crh-associated gene expression in the amygdala DOI Creative Commons
Camila Demaestri, Meghan Gallo,

Elisa Mazenod

и другие.

Neurobiology of Stress, Год журнала: 2022, Номер 20, С. 100484 - 100484

Опубликована: Сен. 1, 2022

Early life adversity (ELA) is a major risk factor for the development of pathology, including anxiety disorders. Neurodevelopmental and behavioral outcomes following ELA are multifaceted influenced heavily by type experienced sex individual experiencing ELA. It remains unclear what properties portend differential neurobiological basis sex-differences negative outcomes. Predictability postnatal environment has emerged as being core feature supporting development, with most salient signals deriving from parental care. care may be distinguishing different forms ELA, degree predictability afforded these manipulations contribute to diversity observed across models. Further, questions remain whether differing levels effects on neurodevelopment expression genes associated pathology. Here, we tested hypothesis that changes in maternal behavior mice would contingent experienced, directly comparing limited bedding nesting (LBN) separation (MS) paradigms. We then altered corticotropin-releasing hormone (Crh), sexually-dimorphic neuropeptide regulates threat-related learning, amygdala male female mice. The LBN manipulation reliably increased entropy care, measure indicates lower between sequences dam behavior. MS rearing similarly frequency nest sorties licking pups but had mixed other aspects dam-, pup-, nest-related behaviors. Increased Crh-related was gene measures showing significant interaction manipulation. Specifically, males, not females, primarily males. present study provides evidence models demonstrates robust consequences experience critically stress responding differences

Язык: Английский

Процитировано

21