Neurobiology of Stress,
Год журнала:
2022,
Номер
20, С. 100484 - 100484
Опубликована: Сен. 1, 2022
Early
life
adversity
(ELA)
is
a
major
risk
factor
for
the
development
of
pathology,
including
anxiety
disorders.
Neurodevelopmental
and
behavioral
outcomes
following
ELA
are
multifaceted
influenced
heavily
by
type
experienced
sex
individual
experiencing
ELA.
It
remains
unclear
what
properties
portend
differential
neurobiological
basis
sex-differences
negative
outcomes.
Predictability
postnatal
environment
has
emerged
as
being
core
feature
supporting
development,
with
most
salient
signals
deriving
from
parental
care.
care
may
be
distinguishing
different
forms
ELA,
degree
predictability
afforded
these
manipulations
contribute
to
diversity
observed
across
models.
Further,
questions
remain
whether
differing
levels
effects
on
neurodevelopment
expression
genes
associated
pathology.
Here,
we
tested
hypothesis
that
changes
in
maternal
behavior
mice
would
contingent
experienced,
directly
comparing
limited
bedding
nesting
(LBN)
separation
(MS)
paradigms.
We
then
altered
corticotropin-releasing
hormone
(Crh),
sexually-dimorphic
neuropeptide
regulates
threat-related
learning,
amygdala
male
female
mice.
The
LBN
manipulation
reliably
increased
entropy
care,
measure
indicates
lower
between
sequences
dam
behavior.
MS
rearing
similarly
frequency
nest
sorties
licking
pups
but
had
mixed
other
aspects
dam-,
pup-,
nest-related
behaviors.
Increased
Crh-related
was
gene
measures
showing
significant
interaction
manipulation.
Specifically,
males,
not
females,
primarily
males.
present
study
provides
evidence
models
demonstrates
robust
consequences
experience
critically
stress
responding
differences
Although
early-life
adversity
can
undermine
healthy
development,
an
evolutionary-developmental
perspective
implies
that
children
growing
up
in
harsh
environments
will
develop
intact,
or
even
enhanced,
skills
for
solving
problems
high‐adversity
contexts
(i.e.,
'hidden
talents').
This
Element
situates
the
hidden
talents
model
within
a
larger
interdisciplinary
framework.
Summarizing
theory
and
research
on
talents,
it
proposes
stress-adapted
represent
form
of
adaptive
intelligence
enabling
individuals
to
function
constraints
environments.
It
discusses
potential
applications
this
multiple
sectors
concerned
with
youth
from
environments,
including
education,
social
services,
juvenile
justice,
compares
contemporary
developmental
resilience
models.
The
approach,
concludes,
offers
exciting
directions
childhood
adversity,
translational
implications
leveraging
more
effectively
tailor
jobs,
interventions
fit
needs
diverse
range
life
circumstances.
Neurobiology of Stress,
Год журнала:
2022,
Номер
20, С. 100484 - 100484
Опубликована: Сен. 1, 2022
Early
life
adversity
(ELA)
is
a
major
risk
factor
for
the
development
of
pathology,
including
anxiety
disorders.
Neurodevelopmental
and
behavioral
outcomes
following
ELA
are
multifaceted
influenced
heavily
by
type
experienced
sex
individual
experiencing
ELA.
It
remains
unclear
what
properties
portend
differential
neurobiological
basis
sex-differences
negative
outcomes.
Predictability
postnatal
environment
has
emerged
as
being
core
feature
supporting
development,
with
most
salient
signals
deriving
from
parental
care.
care
may
be
distinguishing
different
forms
ELA,
degree
predictability
afforded
these
manipulations
contribute
to
diversity
observed
across
models.
Further,
questions
remain
whether
differing
levels
effects
on
neurodevelopment
expression
genes
associated
pathology.
Here,
we
tested
hypothesis
that
changes
in
maternal
behavior
mice
would
contingent
experienced,
directly
comparing
limited
bedding
nesting
(LBN)
separation
(MS)
paradigms.
We
then
altered
corticotropin-releasing
hormone
(Crh),
sexually-dimorphic
neuropeptide
regulates
threat-related
learning,
amygdala
male
female
mice.
The
LBN
manipulation
reliably
increased
entropy
care,
measure
indicates
lower
between
sequences
dam
behavior.
MS
rearing
similarly
frequency
nest
sorties
licking
pups
but
had
mixed
other
aspects
dam-,
pup-,
nest-related
behaviors.
Increased
Crh-related
was
gene
measures
showing
significant
interaction
manipulation.
Specifically,
males,
not
females,
primarily
males.
present
study
provides
evidence
models
demonstrates
robust
consequences
experience
critically
stress
responding
differences