International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 910 - 910
Опубликована: Янв. 4, 2023
Prostate
cancer
(PCa)
is
the
most
common
male
malignancy
and
fifth
leading
cause
of
death
in
men
worldwide.
cells
are
characterized
by
a
hybrid
glycolytic/oxidative
phosphorylation
phenotype
determined
androgen
receptor
signaling.
An
increased
lipogenesis
cholesterogenesis
have
been
described
PCa
cells.
Many
studies
shown
that
enzymes
involved
these
pathways
overexpressed
PCa.
Glutamine
becomes
an
essential
amino
acid
for
cells,
its
metabolism
thought
to
become
attractive
therapeutic
target.
A
crosstalk
between
stromal
occurs
tumor
microenvironment
because
release
different
cytokines
growth
factors
due
changes
extracellular
matrix.
deeper
insight
into
metabolic
may
be
obtained
multi-omic
approach
integrating
genomics,
transcriptomics,
metabolomics,
lipidomics,
radiomics
data.
Journal of Clinical Investigation,
Год журнала:
2022,
Номер
132(7)
Опубликована: Фев. 22, 2022
CD8+
T
cell
longevity
regulated
by
metabolic
activity
plays
important
roles
in
cancer
immunotherapy.
Although
vitro–polarized,
transferred
IL-9–secreting
Tc9
(cytotoxic
lymphocyte
subset
9)
cells
exert
greater
persistence
and
antitumor
efficacy
than
Tc1
cells,
the
underlying
mechanism
remains
unclear.
Here,
we
show
that
tumor-infiltrating
display
significantly
lower
lipid
peroxidation
several
mouse
models,
which
is
strongly
correlated
with
their
persistence.
Using
RNA-sequence
functional
validation,
found
exhibited
unique
programs.
cell–derived
IL-9
activated
STAT3,
upregulated
fatty
acid
oxidation
mitochondrial
activity,
rendered
reduced
resistance
to
tumor-
or
ROS-induced
ferroptosis
tumor
microenvironment.
signaling
deficiency,
inhibiting
increased
of
resulting
impaired
ability.
Similarly,
human
also
expressed
IL9
higher
peroxidation–
ferroptosis-related
genes
circulating
patients
melanoma.
This
study
indicates
regulates
effects
via
IL-9/STAT3/fatty
pathway
regulating
can
be
used
enhance
cell–based
immunotherapy
cancer.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 30, 2022
Ferroptosis
is
an
iron-dependent
regulated
form
of
cell
death
caused
by
excessive
lipid
peroxidation.
This
differed
from
known
forms
in
morphological
and
biochemical
features
such
as
apoptosis,
necrosis,
autophagy.
Cancer
cells
require
higher
levels
iron
to
survive,
which
makes
them
highly
susceptible
ferroptosis.
Therefore,
it
was
found
be
closely
related
the
progression,
treatment
response,
metastasis
various
cancer
types.
Numerous
studies
have
that
ferroptosis
pathway
drug
resistance
cancer.
Some
reduce
their
susceptibility
downregulating
pathway,
resulting
anticancer
therapy.
Induction
restores
sensitivity
drug-resistant
standard
treatments.
are
resistant
conventional
therapies
or
a
high
propensity
metastasize
might
particularly
biological
processes
cellular
components,
epithelial–mesenchymal
transition
(EMT)
noncoding
RNAs,
can
influence
regulating
targeting
may
help
suppress
metastasis.
Those
progresses
revealed
importance
cancer,
In
order
provide
detailed
molecular
mechanisms
therapy
strategies
overcome
these
barriers
not
fully
understood,
we
described
key
its
interaction
with
signaling
pathways
Furthermore,
summarized
for
reversing
targeted
therapy,
chemotherapy,
radiotherapy,
immunotherapy
inhibiting
modulating
Understanding
comprehensive
regulatory
new
insights
enhance
efficacy
drugs,
resistance,
inhibit
Cell Death and Disease,
Год журнала:
2023,
Номер
14(1)
Опубликована: Янв. 31, 2023
Abstract
Recent
research
has
shown
that
ferroptosis,
the
iron-dependent
accumulation
of
lipid
peroxides
leads
to
cell
death,
suppresses
cancer
metastasis.
However,
role
ferroptosis
in
prostate
metastasis
not
been
completely
elucidated.
In
current
study,
we
identified
essential
serum/glucocorticoid
regulated
kinase
2
(SGK2)
promoting
by
inhibiting
ferroptosis.
We
found
expression
SGK2
was
higher
metastatic
and
predicted
poor
clinical
outcomes.
knockdown
inhibited
capacity
cells
vivo
vitro,
while
overexpression
facilitated
phosphorylating
Thr-24
Ser-319
sites
forkhead
box
O1
(FOXO1).
This
process
induced
translocation
FOXO1
from
nucleus
cytoplasm,
relieving
inhibitory
effect
on
glutathione
peroxidase
4
(GPX4).
These
findings
delineated
a
novel
regulation
metastasis,
identifying
new
key
pathway
driving
potentially
providing
treatment
strategies
for
cancer.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 910 - 910
Опубликована: Янв. 4, 2023
Prostate
cancer
(PCa)
is
the
most
common
male
malignancy
and
fifth
leading
cause
of
death
in
men
worldwide.
cells
are
characterized
by
a
hybrid
glycolytic/oxidative
phosphorylation
phenotype
determined
androgen
receptor
signaling.
An
increased
lipogenesis
cholesterogenesis
have
been
described
PCa
cells.
Many
studies
shown
that
enzymes
involved
these
pathways
overexpressed
PCa.
Glutamine
becomes
an
essential
amino
acid
for
cells,
its
metabolism
thought
to
become
attractive
therapeutic
target.
A
crosstalk
between
stromal
occurs
tumor
microenvironment
because
release
different
cytokines
growth
factors
due
changes
extracellular
matrix.
deeper
insight
into
metabolic
may
be
obtained
multi-omic
approach
integrating
genomics,
transcriptomics,
metabolomics,
lipidomics,
radiomics
data.
