Formation and computational implications of assemblies in neural circuits DOI Creative Commons
Christoph Miehl, Sebastian Onasch, Dylan Festa

и другие.

The Journal of Physiology, Год журнала: 2022, Номер 601(15), С. 3071 - 3090

Опубликована: Сен. 7, 2022

Abstract In the brain, patterns of neural activity represent sensory information and store it in non‐random synaptic connectivity. A prominent theoretical hypothesis states that assemblies, groups neurons are strongly connected to each other, key computational units underlying perception memory formation. Compatible with these hypothesised experiments have revealed display synchronous activity, either spontaneously or upon stimulus presentation, exhibit behavioural relevance. While remains unclear how assemblies form work has vastly contributed understanding various interacting mechanisms this process. Here, we review recent literature on assembly formation by categorising involved into four components: plasticity, symmetry breaking, competition stability. We highlight different approaches assumptions behind discuss ideas as unit brain. image

Язык: Английский

Critical Avalanches in Excitation-Inhibition Balanced Networks Reconcile Response Reliability with Sensitivity for Optimal Neural Representation DOI

Zhuda Yang,

Junhao Liang, Changsong Zhou

и другие.

Physical Review Letters, Год журнала: 2025, Номер 134(2)

Опубликована: Янв. 15, 2025

Neural criticality has emerged as a unified framework that reconciles diverse multiscale neuronal dynamics such the irregular firing of individual neurons, sparse synchrony in populations, and emergence scale-free avalanches. However, functional role remains ambiguous. Here, we investigate neural representations response to external signals excitation-inhibition balanced networks. We reveal that, contrast with case for traditional critical branching model, state network simultaneously achieves maximal sensitivity, reliability, optimal representation due presence reliable avalanches induced by signals. further demonstrate heterogeneity inhibitory connections is mechanism underlying representation. Our study addresses longstanding challenge concerning significance criticality, namely intricate coexistence reliability sensitivity.

Язык: Английский

Процитировано

1
Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3 DOI Creative Commons
Jason J. Moore,

Shannon K. Rashid,

E. Bicker

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 28, 2025

Apical and basal dendrites of pyramidal neurons receive anatomically functionally distinct inputs, implying compartment-level functional diversity during behavior. To test this, we imaged in vivo calcium signals from soma, apical dendrites, mouse hippocampal CA3 head-fixed navigation. capture compartment-specific population dynamics, developed computational tools to automatically segment extract accurate fluorescence traces densely labeled neurons. We validated the method on sparsely preparations synthetic data, predicting an optimal labeling density for high experimental throughput analytical accuracy. Our detected rapid, local dendritic activity. Dendrites showed robust spatial tuning, similar soma but with higher activity rates. Across days, remained more stable outperformed decoding animal's position. Thus, population-level differences may reflect input-output functions computations CA3. These will facilitate future studies mapping sub-cellular their relation The authors develop analysis package characterizing neural using optical imaging show that are representations than area

Язык: Английский

Процитировано

1
Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation DOI Creative Commons
Josué Haubrich,

Laura Dolón Vera,

Denise Manahan‐Vaughan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 20, 2025

Abstract During spatial appetitive extinction learning (EL), rodents learn that previously rewarded behavior is no longer rewarded. Renewal of the extinguished enabled by re-exposure to context in which occurred. When renewal response (RR) unrewarded, it rapidly followed (RE). Although hippocampus known be engaged, whether this dynamic supported different brain networks unclear. To clarify this, male rats engaged context-dependent memory acquisition, EL and RR testing a T-Maze. Fluorescence situ hybridization disambiguated somatic immediate early gene expression neuronal somata or RE. Graph analysis revealed pronounced hippocampal connectivity with retrosplenial prefrontal cortex (PFC) during initial RR. By contrast, RE was accompanied shift towards elevated coordinated activity within all subfields. Given β-adrenergic receptors (β-AR) regulate memory, we activated β-AR further scrutinize these network effects. This enhanced prevented Effects were associated initially increased thalamic-hippocampus activity, decrease intraconnectivity predominance PFC. Our findings highlight critical hippocampal-cortical-thalamic underpins behavior, noradrenergic neuromodulation playing pivotal role governing circuit’s dynamics.

Язык: Английский

Процитировано

1
Synaptic plasticity rules driving representational shifting in the hippocampus DOI

Antoine D. Madar,

Anqi Jiang,

Can Dong

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

1
Whole-brain EEG dynamics depending on the stimulus modality and task requirements in oddball tasks DOI
Shiho Kashihara, Tomohisa Asai, Hiroshi Imamizu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 20, 2025

Abstract Electroencephalography (EEG) microstates constitute temporal map configurations that reflect the whole brain electrical state. The dynamics of EEG may serve as an effective discretization method for capturing spatiotemporally continuous neural with high resolution. In this study, we employed polarity-sensitive microstate analysis to investigate whole-brain state transitions during audiovisual oddball tasks. Moreover, examined how sensory modality and its coupling, types response target stimuli, physical presence or absence stimuli affected dynamics. results demonstrated abovementioned factors both behavioral indices event-related potential (ERP) components, particularly P300. Importantly, when considering topographical polarity configuration, E-, which originates within 300 600 ms after stimulus onset coincides typical latency P300 component potentially attentional conscious processes are associated These novel insights into dynamic states cognitive complement traditional ERP analyses.

Язык: Английский

Процитировано

1
The Hippocampal Horizon: Constructing and Segmenting Experience for Episodic Memory DOI
T. W. Ross, Alexander Easton

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 132, С. 181 - 196

Опубликована: Ноя. 24, 2021

Язык: Английский

Процитировано

50
Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse DOI Open Access
Yosif Zaki, William Mau,

Christine Cincotta

и другие.

Neuropsychopharmacology, Год журнала: 2022, Номер 47(11), С. 1992 - 2001

Опубликована: Авг. 8, 2022

Язык: Английский

Процитировано

31
Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex DOI Creative Commons
Benjamin Bessières, Julien P. Dupuis, Laurent Groc

и другие.

Science Advances, Год журнала: 2024, Номер 10(35)

Опубликована: Авг. 30, 2024

Initially hippocampal dependent, memory representations rely on a broadly distributed cortical network as they mature over time. How these engrams acquire stability during systems-level consolidation without compromising their dynamic nature remains unclear. We identified highly responsive “consolidation switch” in the synaptic composition of N -methyl- d -aspartate receptors (NMDARs), which dictates progressive embedding and persistence enduring memories rat cortex. Cortical GluN2B subunit–containing NMDARs were preferentially recruited upon encoding associative olfactory to support neuronal allocation engrams. As proceeds, learning-induced redistribution outward synapses increased GluN2A subunit contribution enabled stabilization remote memories. In contrast, reincorporation subunits occurred subsequent forgetting. By manipulating surface distribution at synapses, we uncovered that rearrangement GluN2B-containing constitutes an essential tuning mechanism determines fate controls malleability.

Язык: Английский

Процитировано

8
Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis DOI Creative Commons

Alicia Ravens,

Kaelan Sullivan,

J. R. Einstein

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 30, 2024

Abstract Current models of learning and memory have focused on cell-autonomous regulation synaptic strength; however, intercellular signaling between cells in the brain is critical for normal cognition. The immediate early gene Arc a repurposed retrotransposon long-term forms plasticity memory. protein virus-like capsids released extracellular vesicles (EVs) that signal cell-to-cell. Here, we find potentiation (LTP) stimuli induce biogenesis EVs by recruiting I-BAR IRSp53 to dendrites, which facilitates capsid assembly release. transfer mRNA neighboring neurons, where translation transferred induces loss surface AMPA-type glutamate receptors. These results show mediate non-cell autonomous depression (LTD), revealing an form may be consolidation.

Язык: Английский

Процитировано

7
Mystery of the memory engram: History, current knowledge, and unanswered questions DOI Creative Commons
Matthew R. Lopez,

S.M.H. Wasberg,

Celia Gagliardi

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 159, С. 105574 - 105574

Опубликована: Фев. 6, 2024

The quest to understand the memory engram has intrigued humans for centuries. Recent technological advances, including genetic labelling, imaging, optogenetic and chemogenetic techniques, have propelled field of research forward. These tools enabled researchers create erase components. While these innovative techniques yielded invaluable insights, they often focus on specific elements trace. Genetic labelling may rely a particular immediate early gene as marker activity, optogenetics activate or inhibit one type neuron, imaging capture activity snapshots in given brain region at times. Yet, memories are multifaceted, involving diverse arrays neuronal subpopulations, circuits, regions that work concert create, store, retrieve information. Consideration contributions both excitatory inhibitory neurons, micro macro circuits across regions, dynamic nature active ensembles, representational drift is crucial comprehensive understanding complex memory.

Язык: Английский

Процитировано

7