Опубликована: Фев. 21, 2022
In what follows, we present results of our recent studies on how ongoing neural oscillations shape task performance (including BCI) and evoked responses. These relate to both pre-stimulus resting state spatio-temporal dynamics.
Язык: Английский
Journal of Neuroscience, Год журнала: 2021, Номер 42(4), С. 643 - 656
Опубликована: Дек. 1, 2021
Previous studies have shown that timing of sensory stimulation during the cardiac cycle interacts with perception. Given natural coupling respiration and activity, we investigated here their joint effects on tactile Forty-one healthy female male human participants reported conscious perception finger near-threshold electrical pulses (33% null trials) decision confidence while electrocardiography, respiratory photoplethysmography were recorded. Participants adapted to expected stimulus onsets preferentially occur late inspiration/early expiration. This closely matched heart rate variation (sinus arrhythmia) across such most frequent occurred period highest probably indicating alertness cortical excitability. Tactile detection was first quadrant after expiration onset. Interindividually, stronger phase-locking task associated higher rates. Regarding cycle, confirmed previous findings diastole than systole newly specified its minimum at 250–300 ms R-peak corresponding pulse wave arrival in finger. Expectation induced a transient deceleration which more pronounced for unconfident ratings. poststimulus modulations linked In summary, demonstrate how tuning integration respiratory-cardiac signals are used optimize performance task. SIGNIFICANCE STATEMENT Mechanistic cognition tend focus brain neglecting contributions body. Here, heartbeat influence perception: corresponds (and presumably alertness/cortical excitability) correlates performance. varies when reaches maximum diastole. Taken together our finding unchanged early event-related potentials conclude these not peripheral physiological artifact but result cognitive processes model body's internal state, make predictions guide behavior, might also tune serve
Язык: Английский
Процитировано
91
Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 29
Опубликована: Фев. 1, 2024
Abstract Magneto- and/or electro-encephalography (M/EEG) are non-invasive clinically relevant tools that have long been used to measure electromagnetic fields in the somatosensory cortex evoked by innocuous and noxious stimuli. Two commonly applied stimulation paradigms produce distinct responses primary (SI) linked sensations electrical median nerve (MN) cutaneous laser-evoked (LE) dorsum of hand, respectively. Despite their prevalence, physiological mechanisms stereotypic macroscale MN LE yet be fully articulated, limiting utility understanding brain dynamics associated with non-painful painful somatosensation. Through a literature review, we detailed features source-localized SI robust reproducible across studies. We showed first peak response at ~20 ms post-stimulus (i.e., N1) corresponds upward-directed deep-to-superficial current flow through cortical laminae, which is followed downward-directed ~30 P1). In contrast, initial occurs later ~170 directed downward opposite direction N1. then examined neocortical circuit contributing each using Human Neocortical Neurosolver (HNN) neural modeling software tool (Neymotin et al., 2020). Using HNN as hypothesis development testing tool, model results predicted can simulated sequence layer-specific thalamocortical cortico-cortical synaptic drive similar previously reported for tactile (S. R. Jones 2007; Neymotin 2020), novel discovery an early excitatory input supragranular layers essential mechanism P1. Model further N1 was generated burst repetitive gamma-frequency (~40 Hz) layers, consistent prior reports activity. These make multiscale predictions about dynamic laminar underlying temporal spectral guide investigations follow-up Ultimately, these findings may help targeted therapeutics pathological somatosensation, such somatic sensitivity acute neuropathic pain.
Язык: Английский
Процитировано
4
eLife, Год журнала: 2021, Номер 10
Опубликована: Сен. 30, 2021
Perception of sensory information is determined by stimulus features (e.g., intensity) and instantaneous neural states excitability). Commonly, it assumed that both are reflected similarly in evoked brain potentials, is, larger amplitudes associated with a stronger percept stimulus. We tested this assumption somatosensory discrimination task humans, simultaneously assessing (i) single-trial excitatory post-synaptic currents inferred from short-latency potentials (SEPs), (ii) pre-stimulus alpha oscillations (8-13 Hz), (iii) peripheral nerve measures. Fluctuations excitability shaped the perceived intensity already during very first cortical response (at ~20 ms) yet demonstrating opposite signatures as compared to effect presented intensity. reconcile discrepancy via common framework based on modulation electro-chemical membrane gradients linking responses, which calls for reconsidering conventional interpretations potential magnitudes encoding.
Язык: Английский
Процитировано
21
eLife, Год журнала: 2023, Номер 12
Опубликована: Март 21, 2023
Response variability is an essential and universal feature of sensory processing behavior. It arises from fluctuations in the internal state brain, which modulate how information represented transformed to guide behavioral actions. In part, brain shaped by recent network activity, fed back through recurrent connections neuronal excitability. However, degree these interactions influence response spatial temporal scales across they operate, are poorly understood. Here, we combined population recordings modeling gain insights into activity modulates thereby impacts visually evoked First, performed cellular-resolution calcium imaging optic tectum monitor ongoing pattern both a cause consequence changes state. We developed minimal model incorporating fast, short range, excitation long-lasting, activity-dependent suppression that reproduced hallmark property tectal - intermittent bursting. next used estimate excitability neurons based on history found this explained portion trial-to-trial responses, as well spatially selective adaptation. Moreover, dynamics also predicted trends such habituation prey-catching. Overall, demonstrate simple interaction motif can be effect upon incidental neural account for experience-dependent effects encoding guided
Язык: Английский
Процитировано
7
Neuroscience Research, Год журнала: 2023, Номер 203, С. 1 - 7
Опубликована: Дек. 22, 2023
Multimodal recording using electroencephalogram (EEG) and other biological signals (e.g., muscle activities, eye movement, pupil diameters, or body kinematics data) is ubiquitous in human neuroscience research. However, the precise time alignment of multiple data from heterogeneous sources (i.e., devices) often arduous due to variable parameters commercially available research devices complex experimental setups. In this review, we introduced versatility a Lab Streaming Layer (LSL)-based application that can overcome two common issues measuring multimodal data: jitter latency. We discussed latency recordings benefits time-synchronization when with devices. addition, computer simulation was performed highlight how millisecond-order readily affects signal-to-noise ratio electrophysiological outcome. Together, argue LSL-based system be used for requiring time-alignment datasets. Studies detect stimulus-induced transient neural responses test hypotheses regarding temporal relationships different functional aspects would benefit most systems.
Язык: Английский
Процитировано
7
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown
Опубликована: Дек. 1, 2022
Abstract Multimodal recording using electroencephalogram (EEG) and other biological signals (e.g., electromyograms, eye movement, pupil information, or limb kinematics) is ubiquitous in human neuroscience research. However, the precise time alignment of data from heterogeneous sources limited due to variable parameters commercially available research devices experimental setups. Here, we introduced versatility a Lab Streaming Layer (LSL)-based application for multimodal recordings high-density EEG such as trackers hand kinematics. To introduce benefit multiple time-synchronized manner, discuss two common issues measuring data: jitter latency. The LSL-based system can be used on time-alignment datasets, detecting stimulus-induced transient neural responses testing hypotheses well-formulated by leveraging millisecond resolution system.
Язык: Английский
Процитировано
7
Computers in Biology and Medicine, Год журнала: 2023, Номер 168, С. 107783 - 107783
Опубликована: Дек. 2, 2023
The mammalian brain exhibits a remarkable diversity of neurons, contributing to its intricate architecture and functional complexity. analysis multimodal single-cell datasets enables the investigation cell types states heterogeneity. In this study, we introduce Neuronal Spike Shapes (NSS), straightforward approach for exploration excitability neurons based on their Action Potential (AP) waveforms. NSS method describes AP waveform triangular representation complemented by set derived electrophysiological (EP) features. To support hypothesis, validate proposed two murine cortical focusing it GABAergic neurons. validation process involves combination NSS-based clustering analysis, features exploration, Differential Expression (DE), Gene Ontology (GO) enrichment analysis. Results show that captures neuronal possess biological relevance independently subtype. particular, (NSS) captures, among others, well-characterized fast-spiking state, supported both transcriptomic validation. Enrichment Analysis reveals voltage-gated potassium (K
Язык: Английский
Процитировано
4
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 13, 2024
Abstract Perception is biased by expectations and previous actions. Pre-stimulus brain oscillations are a potential candidate for implementing biases in the brain. In two EEG studies on somatosensory near-threshold detection, we investigated pre-stimulus neural correlates of an (implicit) choice bias explicit bias. The was introduced informing participants about stimulus probability single-trial level (volatile context) or block-wise (stable context). Behavioural analysis confirmed adjustments decision criterion confidence ratings according to cued probabilities choice-induced biases. beta power with distinct sources sensory higher-order cortical areas predicted implicit biases, respectively, single subject partially mediated impact detection response. We suggest that different perception.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 17, 2024
Abstract Neural states shape perception at earliest cortical processing levels. Previous work in humans showed a relationship between initial excitation, as indicated by the N20 component of somatosensory evoked potential (SEP), pre-stimulus alpha oscillations, and perceived intensity discrimination paradigm. Here we address follow-up question whether these excitability dynamics reflect changes feedforward or feedback signals. We leveraged high-frequency oscillations (HFO) metric for neuronal population spiking activity first excitatory volley cortex, non-invasively extracted from electroencephalography (EEG) data 32 male human participants. Using Bayesian statistics, found evidence against involvement HFO moment-to-moment variability stimulus intensity, contrast to previously observed effects. Given that presumably reflects backpropagating membrane potentials towards apical dendrites, argue top-down processes (e.g., related oscillations) may thus rely on modulations distal dendritic sites involved pyramidal cells rather than output firing their basal compartments.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown
Опубликована: Март 22, 2021
Abstract Previous studies have shown that timing of sensory stimulation during the cardiac cycle interacts with perception. Given natural coupling respiration and activity, we investigated here their joint effects on tactile Forty-one healthy female male human participants reported conscious perception finger near-threshold electrical pulses (33% null trials) decision confidence while electrocardiography, respiratory photoplethysmography were recorded. Participants adapted to expected stimulus onsets preferentially occur late inspiration / early expiration. This closely matched heart rate variation (sinus arrhythmia) across such most frequent occurred period highest probably indicating alertness cortical excitability. Tactile detection was first quadrant after expiration onset. Inter-individually, stronger phase-locking task associated higher rates. Regarding cycle, confirmed previous findings diastole than systole newly specified its minimum at 250 - 300 ms R-peak corresponding pulse wave arrival in finger. Expectation induced a transient deceleration which more pronounced for unconfident ratings. post-stimulus modulations linked In summary, demonstrate how tuning integration respiratory-cardiac signals are used optimize performance task. Significance statement Mechanistic cognition tend focus brain neglecting contributions body. Here, heartbeat influence perception: Respiration corresponds (and presumably alertness/cortical excitability) correlates performance. varies when reaches maximum diastole. Taken together our finding unchanged ERPs conclude these not peripheral physiological artifact but result cognitive processes model body’s internal state, make predictions guide behavior, might also tune serve
Язык: Английский
Процитировано
7