Measures of tonic and phasic activity of the locus coeruleus—norepinephrine system in children with autism spectrum disorder: An event‐related potential and pupillometry study DOI Creative Commons
Yesol Kim, Girija Kadlaskar, Rebecca McNally Keehn

и другие.

Autism Research, Год журнала: 2022, Номер 15(12), С. 2250 - 2264

Опубликована: Сен. 26, 2022

A growing body of research suggests that locus coeruleus-norepinephrine (LC-NE) system may function differently in individuals with autism spectrum disorder (ASD). Understanding the dynamics both tonic (resting pupil diameter) and phasic (pupil dilation response [PDR] event-related potential [ERP]) indices provide meaningful insights about nature LC-NE ASD. Twenty-four children ASD 27 age- nonverbal-IQ matched typically developing (TD) completed two experiments: (1) a resting eye-tracking task to measure diameter, (2) three-stimulus oddball paradigm responsivity using PDR ERP. Consistent prior reports, our results indicate exhibit increased reduced (PDR ERP) activity compared their TD peers. For groups, decreased was associated diameter. Lastly, were primarily related measures attention-deficit/hyperactivity (ADHD), not ASD, symptomatology. These findings expand understanding neurophysiological differences present demonstrate aberrant activation be atypical arousal behaviorally-relevant information

Язык: Английский

Toward a functional future for the cognitive neuroscience of human aging DOI Creative Commons

Zoya Mooraj,

Alireza Salami, Karen L. Campbell

и другие.

Neuron, Год журнала: 2025, Номер 113(1), С. 154 - 183

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Pupil size reveals arousal level fluctuations in human sleep DOI Creative Commons
Manuel Carro‐Domínguez, Stephanie Huwiler,

Stella Oberlin

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 28, 2025

Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans, changes in level believed to be a determining characteristic healthy pathological but tracking fluctuations been methodologically challenging. Here we measured pupil size, an established indicator levels, by safely taping right eye open during overnight tested whether size affects cortical response auditory stimulation. We show change as function events across different temporal scales. particular, our results inversely related occurrence spindle clusters, marker resilience. Additionally, found prior stimulation influence evoked response, most notably delta power, several restorative regenerative functions sleep. Recording provides insights into interplay between oscillations.

Язык: Английский

Процитировано

1
Recent advances in the neuroscience of spontaneous and off-task thought: implications for mental health DOI Open Access
Aaron Kucyi, Julia W. Y. Kam, Jessica R. Andrews‐Hanna

и другие.

Nature Mental Health, Год журнала: 2023, Номер 1(11), С. 827 - 840

Опубликована: Ноя. 2, 2023

Язык: Английский

Процитировано

21
Brainstem fMRI signaling of surprise across different types of deviant stimuli DOI Creative Commons
Audrey Mazancieux, Franck Mauconduit,

A. Amadon

и другие.

Cell Reports, Год журнала: 2023, Номер 42(11), С. 113405 - 113405

Опубликована: Ноя. 1, 2023

Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that elicit phasic activation the locus coeruleus (LC), which releases noradrenaline controls central arousal. However, it unclear whether detection behaviorally relevant selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry perform a mapping deviant-related in subcortical structures. Participants have detect items "local-global" paradigm distinguishes between deviance based on stimulus probability sequence structure. fMRI are distributed many cortical areas. Both types pupil, LC, systems. Our results reveal task-relevant recruits same multiple across computationally different deviance.

Язык: Английский

Процитировано

20
From pupil to the brain: New insights for studying cortical plasticity through pupillometry DOI Creative Commons
Aurelia Viglione, Raffaele Mazziotti, Tommaso Pizzorusso

и другие.

Frontiers in Neural Circuits, Год журнала: 2023, Номер 17

Опубликована: Март 31, 2023

Pupil size variations have been associated with changes in brain activity patterns related specific cognitive factors, such as arousal, attention, and mental effort. The locus coeruleus (LC), a key hub the noradrenergic system of brain, is considered to be regulator control on pupil size, diameter corresponding release norepinephrine (NE). Advances eye-tracking technology open-source software facilitated accurate measurement various experimental settings, leading increased interest using pupillometry track nervous activation state potential biomarker for disorders. This review explores non-invasive fully translational tool studying cortical plasticity starting from recent literature suggesting that could promising technique estimating degree residual human subjects. Given NE known critical mediator includes data revealing importance LC-NE modulating size. Finally, we will provide quantitative complementary measure also pre-clinical studies.

Язык: Английский

Процитировано

19
Pupil size reveals arousal level dynamics in human sleep DOI Creative Commons
Manuel Carro‐Domínguez, Stephanie Huwiler,

Stella Oberlin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 21, 2023

Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are potentially crucial for maintaining proper sleep resilience and memory consolidation. Also in humans, changes level believed to be a determining characteristic healthy pathological but tracking fluctuations been methodologically challenging. Here we measured pupil size, an established indicator levels, during overnight tested whether affects cortical response auditory stimulation. We show size change as function macrostructure microstructural events. In particular, is inversely related occurrence spindle clusters, marker resilience. Additionally, prior stimulation influences evoked response, most notably delta power, several restorative regenerative functions sleep. Recording provides novel insights into interplay between oscillations, opening new avenues future clinical applications diagnosing treating associated with abnormal levels.

Язык: Английский

Процитировано

17
Self-regulating arousal via pupil-based biofeedback DOI Creative Commons
Sarah Nadine Meissner, Marc Bächinger, Sanne Kikkert

и другие.

Nature Human Behaviour, Год журнала: 2023, Номер 8(1), С. 43 - 62

Опубликована: Окт. 30, 2023

The brain's arousal state is controlled by several neuromodulatory nuclei known to substantially influence cognition and mental well-being. Here we investigate whether human participants can gain volitional control of their using a pupil-based biofeedback approach. Our approach inverts mechanism suggested previous literature that links activity the locus coeruleus, one key regulators central pupil dynamics. We show enables acquire size. Applying self-regulation systematically modulates coeruleus other brainstem structures involved in control. Furthermore, it cardiovascular measures such as heart rate, behavioural psychophysiological responses during an oddball task. provide evidence makes system accessible control, finding has tremendous potential for translation clinical applications across various domains, including stress-related anxiety disorders.

Язык: Английский

Процитировано

16
Noradrenaline tracks emotional modulation of attention in human amygdala DOI Creative Commons
Dan Bang, Yi Luo,

Leonardo S. Barbosa

и другие.

Current Biology, Год журнала: 2023, Номер 33(22), С. 5003 - 5010.e6

Опубликована: Окт. 23, 2023

The noradrenaline (NA) system is one of the brain's major neuromodulatory systems; it originates in a small midbrain nucleus, locus coeruleus (LC), and projects widely throughout brain.

Язык: Английский

Процитировано

14
Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy DOI Creative Commons
Alexandre Berger, Elise Beckers, Vincent Joris

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Фев. 13, 2024

The locus coeruleus–norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This known prevent seizure development and induce long-term plastic changes, particularly with release norepinephrine hippocampus. However, requisites become responder therapy mechanisms action are still under investigation. Using MRI, we assessed structural functional characteristics coeruleus microstructural properties coeruleus-hippocampus white matter tracts patients drug-resistant epilepsy responding or not therapy. Twenty-three epileptic cervical stimulation were recruited for this pilot study, including 13 responders partial 10 non-responders. A dedicated MRI acquisition allowed vivo localization computation its contrast (an accepted marker LC integrity). Locus activity was estimated using during an auditory oddball task. Finally, multi-shell diffusion used estimate tracts. These compared between responders/partial non-responders their association duration also explored. In a better response therapy, trends toward lower higher found left medial right caudal portions coeruleus, respectively. An increased contrast, bilaterally over portions, correlated treatment. integrity connections new insights into neurobiology may provide novel markers treatment reflect neuroplasticity occurring brain following implantation.

Язык: Английский

Процитировано

5
Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States DOI Creative Commons
Kevin L. Turner, Kyle W. Gheres, Patrick J. Drew

и другие.

Journal of Neuroscience, Год журнала: 2022, Номер 43(6), С. 949 - 964

Опубликована: Дек. 14, 2022

Arousal state affects neural activity and vascular dynamics in the cortex, with sleep associated large changes local field potential increases cortical blood flow. We investigated relationship between pupil diameter blink rate volume somatosensory cortex male female unanesthetized, head-fixed mice. monitored these variables while mice were awake, during periods of rapid eye movement (REM), non-rapid (NREM) sleep. Pupil was smaller than awake state. Changes coherent both gamma-band power but strength sign this varied arousal observed a strong negative correlation rest NREM sleep, although correlations signals became positive alertness, active whisking, REM. Blinking decreases when mouse asleep. Bilateral coherence dropped following blinking, indicating reset activity. Using only metrics (pupil motion), we could determine ('Awake,' 'NREM,' 'REM') >90% accuracy 5 s resolution. There is hemodynamics mice, reflecting pronounced effects on cerebrovascular dynamics. SIGNIFICANCE STATEMENT Determining critical component any neuroscience experiment. blinking are influenced by state, as cortex. found that strongly related to Mice more likely be after before, resets motion can used reliable, noninvasive indicator As transition from wake back again over timescale seconds, monitoring permits detection events behavioral or resting-state experiments.

Язык: Английский

Процитировано

21