Prolactin Drives Iron Release from Macrophages and Uptake in Mammary Cancer Cells through CD44

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8941 - 8941

Опубликована: Авг. 16, 2024

Iron is an essential element for human health. In humans, dysregulated iron homeostasis can result in a variety of disorders and the development cancers. Enhanced uptake, redistribution, retention cancer cells have been suggested as “iron addiction” pattern cells. This increased positively correlates with rapid tumor growth epithelial-to-mesenchymal transition, which forms basis metastasis. However, source mechanisms adopt to actively acquire not well understood. present study, we report, first time, that peptide hormone, prolactin, exhibits novel function regulating distribution, on top its well-known pro-lactating role. When stimulated by breast increase CD44, surface receptor mediating endocytosis hyaluronate-bound iron, resulting accumulation contrast, macrophages, when treated express more ferroportin, only exporter cells, giving rise net output. Interestingly, co-culturing macrophages pre-stained labile pools without any staining, free condition, demonstrate direct flow from As are one major iron-storage it known infiltrate tumors facilitate their progression, our work therefore presents regulatory role prolactin drive flow, provides new information fine-tuning immune responses microenvironment could potentially benefit therapeutics.

Язык: Английский

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The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis

Journal of Hazardous Materials, Год журнала: 2024, Номер 478, С. 135580 - 135580

Опубликована: Авг. 22, 2024

Язык: Английский

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Cell life-or-death events in osteoporosis: All roads lead to mitochondrial dynamics

Pharmacological Research, Год журнала: 2024, Номер 208, С. 107383 - 107383

Опубликована: Авг. 28, 2024

Mitochondria exhibit heterogeneous shapes and networks within among cell types tissues, also in normal or osteoporotic bone tissues with complex types. This dynamic characteristic is determined by the high plasticity provided mitochondrial dynamics stemmed from responding to survival functional requirements of various cells a specific microenvironments. In contrast, dysfunction, induced dysregulation dynamics, may act as trigger death signals, including common apoptosis other forms programmed (PCD). These PCD processes consisting tightly structured cascade gene expression events, can further influence remodeling facilitating cells. Mitochondrial therefore, drive stand at crossroads life integrating external signals altering metabolism, shape, signal-response properties mitochondria. implies that targeting displays significant potential treatment osteoporosis. Considerable effort has been made osteoporosis emphasize parallel roles mitochondria regulating energy calcium signal transduction, oxidative stress, inflammation, death. However, emerging field dynamics-related not well understood. Herein, bridge gap, we outline latest knowledge on during

Язык: Английский

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FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption

Biology, Год журнала: 2025, Номер 14(1), С. 45 - 45

Опубликована: Янв. 9, 2025

There are three FAM98 family proteins (FAM98A/B/C) in humans and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 murine osteoclasts lysosome trafficking/secretion bone resorption vitro. In this study, we found all Fam98 genes were expressed precursor mature osteoclasts. While the knockdown of Fam98c by a specific short-hairpin RNA (shRNA) osteoclast precursors attenuated osteoclastogenesis, depletion Fam98b an shRNA specifically disrupted trafficking phenotypes similar to shRNA-knockdown our previous study. Loss myeloid was dispensable for trabecular cortical mass mice, as well osteoclastogenesis/bone vitro, possibly due compensation increased expression Fam98a-null These findings indicate play distinct roles osteoclastogenesis function need further investigation future studies.

Язык: Английский

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Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used nuclear technologies, 238 Pu for heat generation 239 energy production weapons. Both emit alpha particles, which pose a significant radiation hazard when incorporated into body. Alpha particles emitted during decay deposit along very short path biological tissues (≈45 μm soft tissues). Thus, defining anatomical locations these deposits is essential to identify cells at risk damage potential malignant transformation. Bone primary site deposition retention. exposures associated with increases osteogenic cancers. preferentially deposited on endosteal endocortical bone surfaces, particularly those surrounded by red versus yellow marrow. Red marrow more vascularized sinusoid network, while largely closed capillary system. Cancellous sites has greater turnover rates relatively plutonium‐related cancers than sites. The relationships particle that include osteoclasts, reversal cells, canopy osteoblasts, lining progenitors basic multicellular unit modeling remodeling reviewed. Differences distributions naturally occurring tumors humans experimental animals noted. This review emphasizes importance retention skeleton relative risks from their progenitors.

Язык: Английский

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