The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract The default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem histology vivo neuroimaging to characterize the anatomy DMN better understand its role information processing cortical communication. Our results show that cytoarchitecturally heterogenous, containing cytoarchitectural types are variably specialized for unimodal, heteromodal memory-related processing. Studying diffusion-based structural connectivity combination with cytoarchitecture, found contains regions receptive input from sensory cortex a core relatively insulated environmental input. Finally, analysis signal flow effective models showed unique amongst networks balancing output across levels hierarchies. Together, our study establishes an anatomical foundation which accounts broad plays human brain function cognition can be developed.

Язык: Английский

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Closing the mechanistic gap: the value of microarchitecture in understanding cognitive networks

Trends in Cognitive Sciences, Год журнала: 2022, Номер 26(10), С. 873 - 886

Опубликована: Июль 30, 2022

Язык: Английский

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A dorsomedial prefrontal cortex-based dynamic functional connectivity model of rumination

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 15, 2023

Abstract Rumination is a cognitive style characterized by repetitive thoughts about one’s negative internal states and common symptom of depression. Previous studies have linked trait rumination to alterations in the default mode network, but predictive brain markers are lacking. Here, we adopt modeling approach develop neuroimaging marker based on variance dynamic resting-state functional connectivity test it across 5 diverse subclinical clinical samples (total n = 288). A whole-brain with dorsomedial prefrontal cortex (dmPFC) emerges as generalizable datasets. refined consisting most important features from virtual lesion analysis further predicts depression scores adults major depressive disorder ( 35). This study highlights role dmPFC provides for rumination.

Язык: Английский

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Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy

Brain, Год журнала: 2023, Номер 146(9), С. 3923 - 3937

Опубликована: Апрель 21, 2023

Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology paralimbic brain regions, particularly in mesiotemporal lobe. Cognitive dysfunction TLE frequent, and affects episodic memory. Crucially, these difficulties challenge quality life patients, sometimes more than seizures, underscoring need to assess neural processes cognitive improve patient management. Our work harnessed a novel conceptual analytical approach spatial gradients microstructural differentiation between cortical areas based on high-resolution MRI analysis. Gradients track region-to-region variations intracortical lamination myeloarchitecture, serving as system-level measure structural functional reorganization. Comparing cortex-wide 21 patients 35 healthy controls, we observed reorganization this gradient driven by reduced cortices remaining cortex marked abnormalities ipsilateral temporopolar dorsolateral prefrontal regions. Findings were replicated an independent cohort. Using post-mortem dataset, that vivo findings reflected topographical cytoarchitecture. We indeed found macroscale changes increased similarity primary sensory/motor Disease-related transcriptomics could furthermore show specificity our over other syndromes. Finally, dedifferentiation was network seen during memory paradigm correlated interindividual differences task accuracy. Collectively, showing pattern microarchitectural regions provide structurally-grounded explanation for large-scale characteristic TLE.

Язык: Английский

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Mapping patterns of thought onto brain activity during movie-watching

eLife, Год журнала: 2025, Номер 13

Опубликована: Янв. 10, 2025

Movie-watching is a central aspect of our lives and an important paradigm for understanding the brain mechanisms behind cognition as it occurs in daily life. Contemporary views ongoing thought argue that ability to make sense events ‘here now’ depend on neural processing incoming sensory information by auditory visual cortex, which are kept check systems association cortex. However, we currently lack how patterns thoughts map onto different when watch film, partly because methods sampling experience disrupt dynamics activity movie-watching. Our study established novel method mapping at moments does not time course or movie-watching experience. We found highlighted engagement with multi-sensory features film episodic features, regions cortex were more active subsequent memory movie was better—on other hand, periods intrusive distraction emerged within frontoparietal system reduced. These results highlight critical role play multi-modal provide evidence reducing films.

Язык: Английский

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Recent advances in the neuroscience of spontaneous and off-task thought: implications for mental health

Nature Mental Health, Год журнала: 2023, Номер 1(11), С. 827 - 840

Опубликована: Ноя. 2, 2023

Язык: Английский

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Hippocampal sharp-wave ripples correlate with periods of naturally occurring self-generated thoughts in humans

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 22, 2024

Abstract Core features of human cognition highlight the importance capacity to focus on information distinct from events in here and now, such as mind wandering. However, brain mechanisms that underpin these self-generated states remain unclear. An emerging hypothesis is depend process memory replay, which linked sharp-wave ripples (SWRs), are transient high-frequency oscillations originating hippocampus. Local field potentials were recorded hippocampus 10 patients with epilepsy for up 15 days, experience sampling was used describe their association ongoing thought patterns. The SWR rates higher during extended periods time when participants’ thoughts more vivid, less desirable, had imaginable properties, exhibited fewer correlations an external task. These data suggest a role patterns humans daily life.

Язык: Английский

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Self-reports map the landscape of task states derived from brain imaging

Communications Psychology, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 22, 2025

Psychological states influence our happiness and productivity; however, estimates of their impact have historically been assumed to be limited by the accuracy with which introspection can quantify them. Over last two decades, studies shown that introspective descriptions psychological correlate objective indicators cognition, including task performance metrics brain function, using techniques like functional magnetic resonance imaging (fMRI). Such evidence suggests it may possible mapping between self-reports experience representations those (e.g., inferred from measures activity). Here, we used machine learning show self-reported experiences across tasks reliably map landscape derived activity. In study, 194 participants provided while performing for contribution different systems was available prior fMRI studies. We combine these reports function form a 'state-space' predicted patterns activity based solely on unseen (N = 101). Our study demonstrates share information Using learning, this shows maps onto 'brain space', i.e., features identified in fMRI.

Язык: Английский

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Decoupling of the pupillary light response during internal attention: The modulating effect of luminance intensity

Acta Psychologica, Год журнала: 2024, Номер 242, С. 104123 - 104123

Опубликована: Янв. 4, 2024

In a world full of sensory stimuli, attention guides us between the external environment and our internal thoughts. While involves processing is devoted to self-generated representations such as planning or spontaneous mind wandering. They both draw from common cognitive resources, thus simultaneous engagement in often leads interference processes. order maintain focus, an attentional mechanism known perceptual decoupling takes effect. This supports cognition by perception information. Two previous studies lab investigated what extent evident voluntary eye movements. Findings showed that effect mediated task modality workload (visuospatial > arithmetic high low, respectively). However, it remains unclear whether extends involuntary behavior, which may not share resources with activities. Therefore, present experiment aimed further elucidate dynamics examining affects pupillary light response (PLR). Specifically, we consistently observed reduced PLR luminance changes medium intensity. strong was less at all affected task. These results suggest effects be consistent particularly context salient visual stimulus.

Язык: Английский

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Inter-subject correlation during long narratives reveals widespread neural correlates of reading ability

NeuroImage, Год журнала: 2023, Номер 282, С. 120390 - 120390

Опубликована: Сен. 24, 2023

Recent work using fMRI inter-subject correlation analysis has provided new information about the brain's response to video and audio narratives, particularly in frontal regions not typically activated by single words. This approach is very well suited study of reading, where narrative central natural experience. But since past reading paradigms have primarily presented words or phrases, influence on semantic processing brain - how that might change with ability remains largely unexplored. In this study, we coherent stories adolescents young adults a wide range abilities. The were alternating visual auditory blocks. We used dimensional identify which better worse readers had varying levels consistency other readers. identified widespread set activity timecourses more similar among than These differences detected standard block activation analyses. Worse higher readers, suggesting "idiosyncratic" responses rather compensatory mechanism. Close inspection confirmed these explained IQ motion. results suggest an expansion current view reflected brain, doing so, they establish as sensitive tool for future studies disorders.

Язык: Английский

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