Frontiers in Molecular Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Июнь 23, 2023
Classic
experiments
with
peripheral
sympathetic
neurons
established
an
absolute
dependence
upon
NGF
for
survival.
A
forgotten
problem
is
how
these
become
resistant
to
deprivation
of
trophic
factors.
The
question
whether
and
can
survive
in
the
absence
support.
However,
mechanism
not
understood
switch
their
phenotype
lose
on
factors,
such
as
BDNF.
Here,
we
approach
by
considering
requirements
support
hippocampal
from
central
nervous
system.
We
developed
cellular
assays
assess
factor
dependency
identified
factors
that
rescue
They
include
enhanced
expression
a
subunit
receptor
(Neurotrophin
Receptor
Homolog,
NRH)
increase
glucocorticoid
neurons.
results
are
significant
since
levels
activity
responsible
many
neuropsychiatric
conditions.
Resistance
may
be
relevant
underlying
basis
longevity,
well
important
element
preventing
neurodegeneration.
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1722 - 1722
Опубликована: Авг. 1, 2024
Patients
with
cirrhosis
often
exhibit
cardiac
autonomic
dysfunction
(CAD),
characterized
by
enhanced
sympathetic
activity
and
diminished
vagal
tone,
leading
to
increased
morbidity
mortality.
This
study
delineates
the
cellular
molecular
mechanisms
associated
altered
neuronal
activities
causing
cirrhosis-induced
CAD.
Biliary
nonbiliary
cirrhotic
rats
were
produced
common
bile
duct
ligation
(CBDL)
intraperitoneal
injections
of
thioacetamide
(TAA),
respectively.
Three
weeks
after
CBDL
or
TAA
injection,
assessment
heart
rate
variability
revealed
imbalance
in
rats.
We
observed
excitability
stellate
ganglion
(SG)
neurons
decreased
intracardiac
(ICG)
compared
sham-operated
controls.
Additionally,
threshold,
rheobase,
action
potential
duration
exhibited
opposite
alterations
SG
ICG
neurons,
along
changes
afterhyperpolarization
duration.
A-
M-type
K⁺
channels
significantly
downregulated
while
upregulated,
downregulation
N-
L-type
Ca
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Окт. 7, 2022
Abstract
Satellite
glial
cells
(SGCs)
are
important
for
proper
neuronal
function
of
primary
sensory
neurons
to
whom
they
provide
homeostatic
support.
Most
research
SGC
has
been
performed
with
in
vitro
studies,
but
recent
advances
calcium
imaging
and
transgenic
mouse
models
have
enabled
this
first
vivo
study
single
cell
inflammation
neuropathic
pain.
We
found
that
naïve
condition
SGCs
do
not
respond
a
time-locked
fashion
firing.
In
painful
inflammatory
states
we
detected
signals
subset
SGCs,
only
suprathreshold
stimulation
the
sciatic
nerve.
Surprisingly
therefore,
conclude
most
seem
develop
at
arbitrary
intervals
directly
linked
activity
patterns.
More
line
expectations,
our
experiments
also
revealed
number
active
was
increased
under
conditions
or
nerve
injury.
This
could
reflect
requirement
support
across
dorsal
root
ganglion
neuron
populations,
which
more
during
such
states.
Frontiers in Molecular Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Июнь 23, 2023
Classic
experiments
with
peripheral
sympathetic
neurons
established
an
absolute
dependence
upon
NGF
for
survival.
A
forgotten
problem
is
how
these
become
resistant
to
deprivation
of
trophic
factors.
The
question
whether
and
can
survive
in
the
absence
support.
However,
mechanism
not
understood
switch
their
phenotype
lose
on
factors,
such
as
BDNF.
Here,
we
approach
by
considering
requirements
support
hippocampal
from
central
nervous
system.
We
developed
cellular
assays
assess
factor
dependency
identified
factors
that
rescue
They
include
enhanced
expression
a
subunit
receptor
(Neurotrophin
Receptor
Homolog,
NRH)
increase
glucocorticoid
neurons.
results
are
significant
since
levels
activity
responsible
many
neuropsychiatric
conditions.
Resistance
may
be
relevant
underlying
basis
longevity,
well
important
element
preventing
neurodegeneration.
