The anterior fusiform gyrus: The ghost in the cortical face machine

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105535 - 105535

Опубликована: Янв. 6, 2024

Face-selective regions in the human ventral occipito-temporal cortex (VOTC) have been defined for decades mainly with functional magnetic resonance imaging. This face-selective VOTC network is traditionally divided a posterior 'core' system thought to subtend face perception, and of anterior temporal lobe as semantic memory component an extended general system. In between these two putative systems lies fusiform gyrus surrounding sulci, affected by susceptibility artifacts. Here we suggest that this methodological gap overlaps contributes conceptual (visual) perception faces. Filling intracerebral recordings direct electrical stimulation reveals robust face-selectivity crucial role region, especially right hemisphere, identity recognition both familiar unfamiliar Based on observations, propose integrated theoretical framework (identity) according which join dots cortical memories.

Язык: Английский

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Intracerebral Electrophysiological Recordings to Understand the Neural Basis of Human Face Recognition

Brain Sciences, Год журнала: 2023, Номер 13(2), С. 354 - 354

Опубликована: Фев. 18, 2023

Understanding how the human brain recognizes faces is a primary scientific goal in cognitive neuroscience. Given limitations of monkey model face recognition, key approach this endeavor recording electrophysiological activity with electrodes implanted inside epileptic patients. However, number challenges that must be overcome for meaningful knowledge to emerge. Here we synthesize 10 year research program combining intracerebral (StereoElectroEncephaloGraphy, SEEG) ventral occipito-temporal cortex (VOTC) large samples participants and fast periodic visual stimulation (FPVS), objectively define, quantify, characterize neural basis recognition. These large-scale studies reconcile wide distribution recognition its (right) hemispheric regional specialization extend face-selectivity anterior regions VOTC, including temporal lobe (VATL) typically affected by magnetic susceptibility artifacts functional resonance imaging (fMRI). Clear spatial dissociations category-selectivity between other stimuli such as landmarks (houses, medial VOTC regions) or written words (left lateralized VOTC) are found, confirming extending neuroimaging observations while supporting validity clinical population tested inform about normal function. The identity - arguably ultimate form beyond mere differences physical features essentially supported selective populations neurons right inferior occipital gyrus lateral portion middle fusiform gyrus. In addition, low-frequency high-frequency broadband iEEG signals appear largely concordant association cortex. We conclude outlining understand next years.

Язык: Английский

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The neuropsychological evaluation of face identity recognition

Neuropsychologia, Год журнала: 2024, Номер 198, С. 108865 - 108865

Опубликована: Март 23, 2024

Face identity recognition (FIR) is arguably the ultimate form of for adult human brain. Even if term prosopagnosia reserved exceptionally rare brain-damaged cases with a category-specific abrupt loss FIR at adulthood, subjective and objective impairments or difficulties are common in neuropsychological population. Here we provide critical overview evaluation both clinicians researchers neuropsychology. occur following many causes that should be identified objectively by general specific, behavioral neural examinations. We refute commonly used dissociation between perceptual memory deficits/tests FIR, since even task involving discrimination unfamiliar face images presented side-by-side relies on cortical memories faces right-lateralized ventral occipito-temporal cortex. Another frequently encountered confusion specific deficits function more impairment semantic (of people), latter being most often anterior temporal lobe damage. Many computerized tests aimed evaluating have appeared over last two decades, as reviewed here. However, despite undeniable strengths, they suffer from ecological limitations, instruction, well lack consideration processing speed qualitative information. Taking into account these issues, recently developed test natural manipulating familiarity, stimulus inversion, correct response times key variable appears promising. The measurement electroencephalographic (EEG) activity frequency domain fast periodic visual stimulation also particularly promising tool to complete enhance assessment FIR.

Язык: Английский

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Single session cross-frequency bifocal tACS modulates visual motion network activity in young healthy population and stroke patients

Brain stimulation, Год журнала: 2024, Номер 17(3), С. 660 - 667

Опубликована: Май 1, 2024

Язык: Английский

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A tight relationship between BOLD fMRI activation/deactivation and increase/decrease in single neuron responses in human association cortex

Опубликована: Фев. 3, 2025

The relationship between Blood-Oxygen-Level-Dependent (BOLD) responses in functional magnetic resonance imaging (fMRI) and increases or decreases neural firing rate across human brain regions, especially the association cortex, remains largely unknown. Here, we contrast direct measures of neuronal activity two adjacent regions fusiform gyrus (FG) associated with fMRI (lateral FG portion) (medial same category-selective activity. In both individual brains tested multiple recording sessions, a frequency-tagging stimulation objectively identified substantial proportion (about 70%) face-selective neurons. While single-units recorded lateral showed selective increase to faces, neurons localized medial decreased spiking selectively faces. Beyond relative reduction faces compared non-face objects, about third single found genuine suppression baseline upon presentation face. These observations clarify nature brain, which can be expressed as active suppressions activity, and, more generally, shed light on physiological basis signal.

Язык: Английский

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A tight relationship between BOLD fMRI activation/deactivation and increase/decrease in single neuron responses in human association cortex

Опубликована: Фев. 3, 2025

The relationship between Blood-Oxygen-Level-Dependent (BOLD) responses in functional magnetic resonance imaging (fMRI) and increases or decreases neural firing rate across human brain regions, especially the association cortex, remains largely unknown. Here, we contrast direct measures of neuronal activity two adjacent regions fusiform gyrus (FG) associated with fMRI (lateral FG portion) (medial same category-selective activity. In both individual brains tested multiple recording sessions, a frequency-tagging stimulation objectively identified substantial proportion (about 70%) face-selective neurons. While single-units recorded lateral showed selective increase to faces, neurons localized medial decreased spiking selectively faces. Beyond relative reduction faces compared non-face objects, about third single found genuine suppression baseline upon presentation face. These observations clarify nature brain, which can be expressed as active suppressions activity, and, more generally, shed light on physiological basis signal.

Язык: Английский

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Sequence chunking through neural encoding of ordinal positions

Trends in Cognitive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Grouping sensory events into chunks is an efficient strategy to integrate information across long sequences such as speech, music, and complex movements. Although can be constructed based on diverse cues (e.g., features, statistical patterns, internal knowledge) recent studies have consistently demonstrated that the by different are all tracked low-frequency neural dynamics. Here, I review evidence chunking drive activity in modality-dependent networks, which interact generate chunk-tracking broad brain areas. Functionally, this work suggests a core computation underlying sequence may assign each event its ordinal position within chunk causally implemented during predictive chunking.

Язык: Английский

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Low and high frequency intracranial neural signals match in the human associative cortex

eLife, Год журнала: 2022, Номер 11

Опубликована: Сен. 8, 2022

In vivo intracranial recordings of neural activity offer a unique opportunity to understand human brain function. Intracranial electrophysiological (iEEG) related sensory, cognitive or motor events manifests mostly in two types signals: event-related local field potentials lower frequency bands (<30 Hz, LF) and broadband the higher end spectrum (>30 High frequency, HF). While most current studies rely exclusively on HF, thought be more focal closely spiking activity, relationship between HF LF signals is unclear, especially associative cortex. Here, we provide large-scale in-depth investigation spatial functional these 2 based from 121 individual brains (8000 recording sites). We measure category-selective responses complex ecologically salient visual stimuli – faces across wide cortical territory ventral occipito-temporal cortex (VOTC), with frequency-tagging method providing high signal-to-noise ratio (SNR) same objective quantification signal noise for ranges. face-selective has SNR VOTC, leading larger number significant electrode contacts anterior temporal lobe, display highly similar spatial, functional, timing properties. Specifically, contrary widespread assumption, our results point nearly identical distribution extent at equal SNR. These observations go long way towards clarifying main iEEG reestablish informative value

Язык: Английский

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Intracerebral electrical stimulation of the face-selective right lateral fusiform gyrus transiently impairs face identity recognition

Neuropsychologia, Год журнала: 2023, Номер 190, С. 108705 - 108705

Опубликована: Окт. 14, 2023

Язык: Английский

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The human auditory cortex concurrently tracks syllabic and phonemic timescales via acoustic spectral flux

Science Advances, Год журнала: 2024, Номер 10(51)

Опубликована: Дек. 20, 2024

Dynamical theories of speech processing propose that the auditory cortex parses acoustic information in parallel at syllabic and phonemic timescales. We developed a paradigm to independently manipulate both linguistic timescales, acquired intracranial recordings from 11 patients who are epileptic listening French sentences. Our results indicate (i) timescales reflected spectral flux; (ii) during comprehension, tracks timescale theta range, while neural activity alpha-beta range phase locks timescale; (iii) these dynamics occur simultaneously share joint spatial location; (iv) flux embeds two timescales-in low-beta ranges-across 17 natural languages. These findings help us understand how human brain extracts continuous signal multiple simultaneously, prerequisite for subsequent processing.

Язык: Английский

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