Cortical interneurons: fit for function and fit to function? Evidence from development and evolution

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 24, 2023

Abstract Cortical inhibitory interneurons form a broad spectrum of subtypes. This diversity suggests division labour, in which each cell type supports distinct function. In the present era optimisation-based algorithms, it is tempting to speculate that these functions were evolutionary or developmental driving force for we see mature mammalian brain. this study, evaluated hypothesis using two most common interneuron types, parvalbumin (PV) and somatostatin (SST) expressing cells, as examples. PV SST control activity bodies apical dendrites excitatory pyramidal respectively, due combination anatomical synaptic properties. But was compartment-specific inhibition indeed function cells originally evolved? Does compartmental structure shape diversification over development? To address questions, reviewed reanalysed publicly available data on development evolution one hand, morphology other. These speak against idea compartment drove into interneurons. particular, late, while are likely committed particular fate (PV vs. SST) during early development. Moreover, comparative anatomy single RNA-sequencing indicate but not existed last ancestor mammals reptiles. Specifically, turtle songbird also express Elfn1 Cbln4 genes thought play role mammals. therefore evolved developed properties allow them provide before there selective pressure suggest resulted from different only later co-opted seems serve today. Future experiments could further test our computational reconstruction ancestral protein sequences.

Язык: Английский

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Precise Spiking Motifs in Neurobiological and Neuromorphic Data

Опубликована: Ноя. 17, 2022

Why do neurons communicate through spikes? By definition, spikes are all-or-none neural events which occur at continuous times. In other words, on one side binary, existing or not without further details, and the can any asynchronous time, need for a centralized clock. This stands in stark contrast to analog representation of values discretized timing classically used digital processing base modern-day networks. As systems almost systematically use this so-called event-based living world, better understanding phenomenon remains fundamental challenge neurobiology order interpret profusion recorded data. With growing intelligent embedded systems, it also emerges as new computing paradigm enable efficient operation class sensors computers, called neuromorphic, could significant gains computation time energy consumption — major societal issue era economy global warming. review paper, we provide evidence from biology, theory engineering that precise plays crucial role our efficiency

Язык: Английский

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Chemogenetic silencing reveals presynaptic Gi/o protein-mediated inhibition of synchronized activity in the developing hippocampus in vivo

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 2, 2024

The development of neuronal circuits is an activity-dependent process. Research aimed at deciphering the learning rules governing these developmental refinements increasingly utilizing a class chemogenetic tools that employ Gi/o protein signaling (Gi-DREADDs) for silencing. However, their mechanisms action and inhibitory efficacy in immature neurons with incompletely developed are poorly understood. Here, we analyze impact on cellular network excitability neonatal hippocampus by expressing Gi-DREADD hM4Di telencephalic glutamatergic mice both sexes. Using acousto-optic two-photon Ca2+ imaging, report activation leads to complete arrest spontaneous synchronized activity CA1 vitro. Electrophysiological analyses demonstrate hM4Di-mediated silencing not accounted changes intrinsic pyramidal cells (PCs). Instead, robustly restrains synaptic glutamate release first postnatal week, effectively reducing recurrent excitation CA1. In vivo, inhibition through potently suppresses early sharp waves (eSPWs) discontinuous oscillatory head-fixed before eye opening. summary, dampens neurotransmission presynaptic mechanism sufficient terminate Our findings have implications designing interpreting experiments Gi-DREADDs further point potential role Gi/o-dependent endogenous neuromodulators hippocampal development.

Язык: Английский

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Coincident development and synchronization of sleep-dependent delta in the cortex and medulla

Current Biology, Год журнала: 2024, Номер 34(12), С. 2570 - 2579.e5

Опубликована: Май 20, 2024

Язык: Английский

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Chemogenetic silencing reveals presynaptic Gi/o protein-mediated inhibition of developing hippocampal synchrony in vivo

iScience, Год журнала: 2024, Номер 27(10), С. 110997 - 110997

Опубликована: Сен. 20, 2024

Язык: Английский

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