Trends in Neurosciences,
Год журнала:
2023,
Номер
46(10), С. 847 - 862
Опубликована: Авг. 28, 2023
To
understand
human
brain
development
it
is
necessary
to
describe
not
only
the
spatiotemporal
patterns
of
neurodevelopment
but
also
neurobiological
mechanisms
that
underlie
them.
Human
neuroimaging
studies
have
provided
evidence
for
a
hierarchical
sensorimotor-to-association
(S–A)
axis
cortical
neurodevelopment.
Understanding
biological
this
program
using
traditional
approaches
has
been
challenging.
Animal
models
used
identify
periods
enhanced
experience-dependent
plasticity
–
'critical
periods'
progress
along
hierarchies
and
are
governed
by
conserved
set
promote
then
restrict
plasticity.
In
review
we
hypothesize
S–A
in
humans
partly
driven
cascading
maturation
critical
period
mechanisms.
We
how
recent
advances
vivo
provide
promising
path
toward
testing
hypothesis
linking
signals
derived
from
non-invasive
imaging
European Neuropsychopharmacology,
Год журнала:
2024,
Номер
82, С. 44 - 52
Опубликована: Март 14, 2024
Parvalbumin-expressing
(PV+)
interneurons
represent
one
of
the
most
abundant
subclasses
cortical
interneurons.
Owing
to
their
specific
electrophysiological
and
synaptic
properties,
PV+
are
essential
for
gating
pacing
activity
excitatory
neurons.
In
particular,
critically
involved
in
generating
maintaining
rhythms
gamma
frequency,
which
complex
cognitive
functions.
Deficits
have
been
frequently
reported
postmortem
studies
schizophrenia
patients,
alterations
oscillations
a
prominent
feature
disease.
Here,
I
summarise
main
features
review
clinical
preclinical
linking
developmental
dysfunction
with
pathophysiology
schizophrenia.
Journal of Neuroscience,
Год журнала:
2022,
Номер
42(46), С. 8716 - 8728
Опубликована: Окт. 17, 2022
Sensory
driven
activity
during
early
life
is
critical
for
setting
up
the
proper
connectivity
of
sensory
cortices.
We
ask
here
whether
social
play
behavior,
a
particular
form
interaction
that
highly
abundant
postweaning
development,
equally
important
connections
in
developing
prefrontal
cortex
(PFC).
Young
male
rats
were
deprived
from
with
peers
period
when
behavior
normally
peaks
[postnatal
day
21–42]
(SPD
rats),
followed
by
resocialization
until
adulthood.
recorded
synaptic
currents
layer
5
cells
slices
medial
PFC
adult
SPD
and
control
observed
inhibitory
reduced
slices,
while
excitatory
unaffected.
This
was
associated
decrease
perisomatic
synapses
parvalbumin-positive
GABAergic
cells.
In
parallel
experiments,
achieved
more
reversals
probabilistic
reversal
learning
(PRL)
task,
which
depends
on
integrity
PFC,
using
simplified
cognitive
strategy
than
controls.
Interestingly,
we
one
daily
hour
partially
rescued
behavioral
performance
PRL,
but
did
not
prevent
inputs.
Our
data
demonstrate
importance
unrestricted
development
skills
adulthood
show
specific
alterations
can
result
complex
outcome.
SIGNIFICANCE
STATEMENT
study
addressed
question
juvenile
contributes
to
functional
found
had
been
(social
deprivation
-
SPD)
showed
reduction
solve
task
Providing
these
rats,
synapses.
results
key
role
emphasize
relation
between
circuit
function.
Progress in Neurobiology,
Год журнала:
2022,
Номер
218, С. 102338 - 102338
Опубликована: Авг. 10, 2022
Modern
life
poses
many
threats
to
good-quality
sleep,
challenging
brain
health
across
the
lifespan.
Curtailed
or
fragmented
sleep
may
be
particularly
damaging
during
adolescence,
when
disruption
by
delayed
chronotypes
and
societal
pressures
coincides
with
our
brains
preparing
for
adult
via
intense
refinement
of
neural
connectivity.
These
vulnerabilities
converge
on
prefrontal
cortex,
one
last
regions
mature
a
central
hub
limbic-cortical
circuits
underpinning
decision-making,
reward
processing,
social
interactions
emotion.
Even
subtle
cortical
development
adolescence
therefore
have
enduring
impact.
In
this
review,
we
integrate
synaptic
circuit
mechanisms,
glial
biology,
neurophysiology
epidemiology,
frame
hypothesis
highlighting
implications
adolescent
circuitry
cortex.
Convergent
evidence
underscores
importance
acknowledging,
quantifying
optimizing
sleep's
contributions
normative
lifelong
mental
health.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
159, С. 105605 - 105605
Опубликована: Фев. 27, 2024
All
individuals
on
planet
earth
are
sensitive
to
the
environment,
but
some
more
than
others.
These
individual
differences
in
sensitivity
environments
seen
across
many
animal
species
including
humans,
and
can
influence
personalities
as
well
vulnerability
resilience
mental
disorders.
Yet,
little
is
known
about
underlying
brain
mechanisms.
Key
genes
that
contribute
environmental
serotonin
transporter,
dopamine
D4
receptor
brain-derived
neurotrophic
factor
genes.
By
synthesizing
neurodevelopmental
findings
of
these
genetic
factors,
discussing
them
through
lens
mechanisms
related
periods,
which
phases
heightened
neuronal
plasticity
during
a
certain
network
being
finetuned
by
experiences,
we
propose
factors
delay
extend
postnatal
periods.
This
may
explain
why
show
behavioral
features
characteristic
young
state
at
level
sensory
information
processing,
such
reduced
filtering
or
blockade
irrelevant
information,
resulting
processing
system
'keeps
all
options
open'.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
153, С. 105378 - 105378
Опубликована: Авг. 27, 2023
Adolescence
is
a
time
of
significant
neurocognitive
development.
Prolonged
maturation
prefrontal
cortex
(PFC)
through
adolescence
has
been
found
to
support
improvements
in
executive
function.
Changes
excitatory
and
inhibitory
mechanisms
critical
period
plasticity
have
be
present
the
PFC
adolescence,
suggesting
that
environment
may
greater
effect
on
development
during
this
time.
Stress
one
factor
known
affect
neurodevelopment
increasing
risk
for
psychopathology.
However,
less
about
how
stress
experienced
could
adolescent-specific
cognitive
outcomes.
In
review,
we
synthesize
findings
from
human
animal
literatures
looking
at
experience
cognition
frontal
neural
activity.
Studies
indicate
enhancing
effects
acute
excitation
within
specific
contexts,
while
chronic
generally
dampens
processes
impairs
cognition.
We
propose
model
plasticity,
thus
potentially
altering
neurodevelopmental
trajectories
lead
