Cell Reports, Год журнала: 2025, Номер 44(3), С. 115432 - 115432
Опубликована: Март 1, 2025
Язык: Английский
Опубликована: Апрель 23, 2025
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes constraints on cancer cells. The created by the tumor microenvironment can lead vulnerabilities cancers. Identifying and that arise cancers provide new insight into biology identify promising antineoplastic targets. To how constrains metabolism pancreatic tumors, we challenged cells with microenvironmental levels analyzed changes cell metabolism. We found arginine perturbs saturated monounsaturated fatty acid synthesis suppressing lipogenic transcription factor SREBP1. Synthesis these acids critical for maintaining balance saturated, monounsaturated, polyunsaturated membranes. As consequence synthesis, are unable maintain lipid homeostasis when exposed acids, leading death ferroptosis. sum, restriction cancers, renders vulnerable polyunsaturated-enriched fat sources.
Язык: Английский
Процитировано
0
Опубликована: Апрель 23, 2025
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes constraints on cancer cells. The created by the tumor microenvironment can lead vulnerabilities cancers. Identifying and that arise cancers provide new insight into biology identify promising antineoplastic targets. To how constrains metabolism pancreatic tumors, we challenged cells with microenvironmental levels analyzed changes cell metabolism. We found arginine perturbs saturated monounsaturated fatty acid synthesis suppressing lipogenic transcription factor SREBP1. Synthesis these acids critical for maintaining balance saturated, monounsaturated, polyunsaturated membranes. As consequence synthesis, are unable maintain lipid homeostasis when exposed acids, leading death ferroptosis. sum, restriction cancers, renders vulnerable polyunsaturated-enriched fat sources.
Язык: Английский
Процитировано
0
Metabolites, Год журнала: 2023, Номер 13(7), С. 872 - 872
Опубликована: Июль 22, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year survival rates around 10%. The only curative option remains complete surgical resection, but due to delay in diagnosis, less than 20% patients are eligible for surgery. Therefore, discovering diagnostic biomarkers early detection crucial improving clinical outcomes. Metabolomics has become a powerful technology biomarker discovery, and several metabolomic-based panels have been proposed PDAC these advances not yet translated into clinic. this review focused on summarizing metabolites identified diagnosis last five years. Bibliographic searches were performed PubMed, Scopus WOS databases, using terms “Biomarkers, Tumor”, “Pancreatic Neoplasms”, “Early Diagnosis”, “Metabolomics” “Lipidome” (January 2018–March 2023), resulted selection fourteen original studies that compared subjects other pancreatic diseases. These investigations showed amino acid lipid metabolic pathways as most commonly altered, reflecting their potential research. Furthermore, relevant such glucose lactate detected pancreas tissue body fluids from patients. Our results suggest use metabolomics robust approach improve PDAC. However, heterogeneity respect techniques used further will be needed validate utility biomarkers.
Язык: Английский
Процитировано
10
Biophysics Reviews, Год журнала: 2024, Номер 5(2)
Опубликована: Апрель 10, 2024
Rapid advances in tissue engineering have resulted more complex and physiologically relevant 3D
Язык: Английский
Процитировано
3
Cell Reports, Год журнала: 2025, Номер 44(3), С. 115432 - 115432
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0