Oscillatory vs. non‐oscillatory subthalamic beta activity in Parkinson's disease DOI
Jesús Pardo‐Valencia, C. Fernández, Fernando Alonso‐Frech

и другие.

The Journal of Physiology, Год журнала: 2023, Номер 602(2), С. 373 - 395

Опубликована: Дек. 12, 2023

Abstract Parkinson's disease is characterized by exaggerated beta activity (13–35 Hz) in cortico‐basal ganglia motor loops. Beta includes both periodic fluctuations (i.e. oscillatory activity) and aperiodic reflecting spiking excitation/inhibition balance non‐oscillatory activity). However, the relative contribution, dopamine dependency clinical correlations of vs . remain unclear. We recorded, modelled analysed subthalamic local field potentials parkinsonian patients at rest while off or on medication. Autoregressive modelling with additive 1/ f noise clarified relationships between measures time domain amplitude duration bursts) frequency power sharpness spectral peak) activity: burst are specifically sensitive to activity, whereas ambiguously activity. Our experimental data confirmed model predictions assumptions. subsequently effect levodopa, obtaining strong‐to‐extreme Bayesian evidence that reduced medication, moderate for absence modulation component. Finally, component correlated rate progression disease. Methodologically, these results provide an integrative understanding beta‐based biomarkers relevant adaptive deep brain stimulation. Biologically, they suggest primarily dependent may play a role not only pathophysiology but also image Key points true synaptic The Burst Only dopamine‐dependent. Stronger correlates faster

Язык: Английский

Insights and opportunities for deep brain stimulation as a brain circuit intervention DOI Creative Commons
Wolf‐Julian Neumann, Andreas Horn, Andrea A. Kühn

и другие.

Trends in Neurosciences, Год журнала: 2023, Номер 46(6), С. 472 - 487

Опубликована: Апрель 25, 2023

Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into the dynamic circuit architecture of disorders. This Review illustrates our current understanding pathophysiology movement disorders their underlying circuits that are modulated with DBS. It proposes principles pathological network synchronization patterns like beta activity (13–35 Hz) in Parkinson's disease. We describe alterations from microscale including local synaptic via modulation mesoscale hypersynchronization to changes whole-brain macroscale connectivity. Finally, outlook on advances for clinical innovations next-generation neurotechnology provided: preoperative connectomic targeting feedback controlled closed-loop adaptive DBS as individualized network-specific interventions.

Язык: Английский

Процитировано

49
Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies DOI
Yevgenia Rosenblum, Tamara Shiner, Noa Bregman

и другие.

Journal of Neurology, Год журнала: 2023, Номер 270(8), С. 3958 - 3969

Опубликована: Май 3, 2023

Язык: Английский

Процитировано

34
Aperiodic components of local field potentials reflect inherent differences between cortical and subcortical activity DOI Creative Commons
Alan Bush, Jasmine Zou, Witold Lipski

и другие.

Cerebral Cortex, Год журнала: 2024, Номер 34(5)

Опубликована: Май 1, 2024

Abstract Information flow in brain networks is reflected local field potentials that have both periodic and aperiodic components. The 1/fχ component of the power spectra tracks arousal correlates with other physiological pathophysiological states. Here we explored activity human thalamus basal ganglia relation to simultaneously recorded cortical activity. We elaborated on parameterization implemented by specparam (formerly known as FOOOF) avoid parameter unidentifiability obtain independent more easily interpretable parameters. This allowed us seamlessly fit without an knee, a captures change slope component. found exponent χ, which reflects decay frequency, correlated Parkinson’s disease symptom severity. Interestingly, no knee was detected from thalamus, pallidum, or subthalamic nucleus, exhibited significantly lower than cortex. These differences were replicated epilepsy patients undergoing intracranial monitoring included thalamic recordings. consistently lack all subcortical recordings may reflect cytoarchitectonic and/or functional differences. Significance statement can be modeled produce useful reproducible indices neural refined widely used phenomenological model for extracting parameters (namely exponent, offset knee), cortical, ganglia, potentials, unique cohorts movement disorders patients. motor cortex higher Parkinson's severe symptoms, suggesting features potential electrophysiological biomarkers symptoms. Remarkably, conspicuous signals compared those neocortex.

Язык: Английский

Процитировано

10
Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation DOI Creative Commons
Atefeh Asadi, Alex I. Wiesman, Christoph Wiest

и другие.

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 20, 2025

Abstract Neuromodulation therapy comprises a range of non-destructive and adjustable methods for modulating neural activity using electrical stimulations, chemical agents, or mechanical interventions. Here, we discuss how electrophysiological brain recording imaging at multiple scales, from cells to large-scale networks, contribute defining the target location stimulation parameters neuromodulation, with an emphasis on deep (DBS).

Язык: Английский

Процитировано

1
Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson's Disease DOI Open Access
Ksenia Sayfulina, Veronika Filyushkina, Svetlana Usova

и другие.

European Journal of Neuroscience, Год журнала: 2025, Номер 61(1)

Опубликована: Янв. 1, 2025

ABSTRACT Excessive beta oscillations in the subthalamic nucleus are established as a primary electrophysiological biomarker for motor impairment Parkinson's disease and currently used feedback signals adaptive deep brain stimulation systems. However, there is still need optimization of parameters identification optimal biomarkers that can accommodate varying patient conditions, such ON OFF levodopa medication. The precise boundaries ‘pathological’ oscillatory ranges, associated with different aspects impairment, not fully clarified. In this study, we hypothesized analysing periodic aperiodic components activity separately identifying functionally distinct subranges within 8–35 Hz based on properties may reveal robust specific impairment. We analysed 14 patients disease. Local field potentials were recorded at rest from externalized electrodes postoperatively, both before after administration. showed administration suppressed across broad frequency range (11–32 Hz) increased slope component. Changes correlated symptom alleviation. Periodic was linked to severity: Peak amplitude 14‐ 20‐Hz overall state, whereas 7‐ 11‐Hz bradykinesia state. Our findings suggest that, addition low beta, alpha component serve promising potential DBS

Язык: Английский

Процитировано

1
Aperiodic EEG Predicts Variability of Visual Temporal Processing DOI
Michele Deodato, David Melcher

Journal of Neuroscience, Год журнала: 2024, Номер 44(40), С. e2308232024 - e2308232024

Опубликована: Авг. 21, 2024

The human brain exhibits both oscillatory and aperiodic, or 1/

Язык: Английский

Процитировано

6
Exploring aperiodic activity in first episode schizophrenia spectrum psychosis: A resting-state EEG analysis DOI Creative Commons

Ruby J. Earl,

Talitha C. Ford, Jarrad A. G. Lum

и другие.

Brain Research, Год журнала: 2024, Номер 1840, С. 149052 - 149052

Опубликована: Июнь 5, 2024

Abnormalities in brain oscillatory patterns have long been observed schizophrenia and psychotic disorders more broadly. However, far less is known about aperiodic neural activity these disorders, which has linked to excitation/inhibition balance neuronal population spiking within the brain. Here, we analysed resting-state electroencephalographic (EEG) recordings from 43 first episode spectrum psychosis (FESSP) patients 28 healthy controls examine whether disrupted FESSP. We further assessed potential associations between FESSP clinical symptom severity using Brief Psychiatric Rating Scale (BPRS), for Assessment of Negative Symptoms (SANS), Positive (SAPS). found no significant differences either 1/f-like exponent or broadband offset control groups when analysing global signal averaged across all EEG electrodes. Bayesian analyses supported non-significant findings. additional non-parametric cluster-based permutation did identify reduced group, relative broad central, temporal, parietal select frontal regions. No were examining participants, irrespective antipsychotic medication status. was shown predict BPRS SANS scores naive patients. In sum, this research presents an initial analysis FESSP, offering preliminary evidence altered disorder. This contributes a broader understanding dynamics early psychosis.

Язык: Английский

Процитировано

5
The neurophysiological brain-fingerprint of Parkinson’s disease DOI Creative Commons
Jason da Silva Castanheira,

Alex I Wiesman,

Justine Y Hansen

и другие.

EBioMedicine, Год журнала: 2024, Номер 105, С. 105201 - 105201

Опубликована: Июнь 21, 2024

Research in healthy young adults shows that characteristic patterns of brain activity define individual "brain-fingerprints" are unique to each person. However, variability these brain-fingerprints increases individuals with neurological conditions, challenging the clinical relevance and potential impact approach. Our study derived from neurophysiological associated pathophysiological traits patients Parkinson's disease (PD).

Язык: Английский

Процитировано

4
Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson’s disease DOI Creative Commons
Mariëlle J. Stam, Bernadette C.M. van Wijk, Arthur W.G. Buijink

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract Beta oscillations (± 13-35 Hz) and aperiodic spectral features extracted from local field potential (LFP) recordings have been identified as promising physiomarkers for adaptive deep brain stimulation (aDBS) in Parkinson's disease. However, the long-term consistency of these signal patients years after DBS implantation is still unclear. Bilateral subthalamic nucleus LFPs were recorded twelve with an average inter-recording interval 137 days, during rest, a finger-to-nose task speech, switched off on. Intra-class correlation coefficients indicated moderate between-visit offset exponent but good to excellent beta peak power. Task execution induced power changes that statistically comparable across visits. Results remained inconclusive regarding which peaks exhibited strongest suppression post-stimulation. Our findings support primary physiomarker aDBS, components serving supplementary markers.

Язык: Английский

Процитировано

0
Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy DOI Creative Commons
X Liu, Jing Guang, Stefanie Glowinsky

и другие.

npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)

Опубликована: Июнь 15, 2024

The subthalamic nucleus (STN) is pivotal in basal ganglia function health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson's patients undergoing deep brain stimulation (DBS) allowed differentiation between input, represented by local field potential (LFP), output, reflected spike discharge rate (SPK). As with many natural systems, STN neuronal activity exhibits power-law dynamics characterized the exponent α. We, therefore, dissected data into aperiodic periodic components using Fitting Oscillations & One Over F (FOOOF) tool. LFP showed significantly higher exponents than SPK. Additionally, SPK beta oscillations demonstrated a downward frequency shift compared to LFP. Finally, spiking parameters explained significant fraction variance burden treatment efficacy unique input-output may clarify its role physiology can be utilized closed-loop DBS therapy.

Язык: Английский

Процитировано

3