Highly
potent
animal
stem
cells
either
self
renew
or
launch
complex
differentiation
programs,
using
mechanisms
that
are
only
partly
understood.
Drosophila
female
germline
(GSCs)
perpetuate
without
change
over
evolutionary
time
and
generate
cystoblast
daughters
develop
into
nurse
oocytes.
Cystoblasts
initiate
by
generating
a
transient
syncytial
state,
the
cyst,
increasing
pericentromeric
H3K9me3
modification,
actions
likely
to
suppress
transposable
element
activity.
Relatively
open
GSC
chromatin
is
further
restricted
Polycomb
repression
of
testis
somatic
cell-expressed
genes
briefly
active
in
early
germ
cells.
Subsequently,
Neijre/CBP
Myc
help
upregulate
growth
reprogram
metabolism
altering
mitochondrial
transmembrane
transport,
gluconeogenesis,
other
processes.
In
all
these
respects
resembles
development
totipotent
zygote.
We
propose
cell
state
was
shaped
need
resist
transposon
activity
timescales.
Highly
potent
animal
stem
cells
either
self
renew
or
launch
complex
differentiation
programs,
using
mechanisms
that
are
only
partly
understood.
Drosophila
female
germline
(GSCs)
perpetuate
without
change
over
evolutionary
time
and
generate
cystoblast
daughters
develop
into
nurse
oocytes.
Cystoblasts
initiate
by
generating
a
transient
syncytial
state,
the
cyst,
increasing
pericentromeric
H3K9me3
modification,
actions
likely
to
suppress
transposable
element
activity.
Relatively
open
GSC
chromatin
is
further
restricted
Polycomb
repression
of
testis
somatic
cell-expressed
genes
briefly
active
in
early
germ
cells.
Subsequently,
Neijre/CBP
Myc
help
upregulate
growth
reprogram
metabolism
altering
mitochondrial
transmembrane
transport,
gluconeogenesis,
other
processes.
In
all
these
respects
resembles
development
totipotent
zygote.
We
propose
cell
state
was
shaped
need
resist
transposon
activity
timescales.
