The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature
eLife,
Год журнала:
2023,
Номер
12
Опубликована: Март 2, 2023
Classic
models
consider
working
memory
(WM)
and
long-term
as
distinct
mental
faculties
that
are
supported
by
different
neural
mechanisms.
Yet,
there
significant
parallels
in
the
computation
both
types
of
require.
For
instance,
representation
precise
item-specific
requires
separation
overlapping
representations
similar
information.
This
has
been
referred
to
pattern
separation,
which
can
be
mediated
entorhinal-DG/CA3
pathway
medial
temporal
lobe
(MTL)
service
episodic
memory.
However,
although
recent
evidence
suggested
MTL
is
involved
WM,
extent
supports
WM
remained
elusive.
Here,
we
combine
an
established
orientation
task
with
high-resolution
fMRI
test
hypothesis
retains
visual
a
simple
surface
feature.
Participants
were
retrospectively
cued
retain
one
two
studied
gratings
during
brief
delay
period
then
tried
reproduce
precisely
possible.
By
modeling
delay-period
activity
reconstruct
retained
content,
found
anterior-lateral
entorhinal
cortex
(aLEC)
hippocampal
DG/CA3
subfield
contain
information
associated
subsequent
recall
fidelity.
Together,
these
results
highlight
contribution
circuitry
representation.
Язык: Английский
Neurocognitive dynamics and behavioral differences of symmetry and asymmetry processing in working memory: insights from fNIRS
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 8, 2025
Abstract
Symmetry
is
a
ubiquitous
property
of
the
visual
world.
It
facilitates
cognitive
processing
and
fosters
aesthetic
appeal.
Despite
its
importance
to
experience
perceptual
prominence,
integration
symmetry
in
working
memory
remains
underexplored.
In
our
study,
participants
engaged
novel
task
involving
both
symmetrical
asymmetrical
stimuli,
while
their
brain
activity
was
monitored
using
functional
Near
Infrared
Spectroscopy
(fNIRS).
The
study
revealed
that
significantly
enhances
performance.
improves
performance,
with
stimuli
leading
higher
accuracy
faster
recall
than
ones,
especially
under
high
load.
This
effect
varies
type
symmetry,
diagonal
being
most
effective.
Neuroimaging
data
showed
distinct
activation
patterns
when
processed
particularly
memory-straining
condition.
Significant
differences
were
observed
various
regions,
lateral
occipital,
posterior
parietal,
medial
dorsolateral
prefrontal
cortices
reacting
decreased
oxygenated
hemoglobin
(HbO),
left
orbitofrontal
(HbO)
right
ventrolateral
cortex
(HbO
HbR)
concentration
increased.
Overall,
findings
highlight
complex,
region-specific
response
emphasizing
nuanced
role
during
tasks
potential
implication
for
creative
thinking.
Язык: Английский
Reactivation of prior responses drives serial dependence and stabilizes working memory representations
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(32), С. e2399232024 - e2399232024
Опубликована: Июнь 19, 2024
Serial
dependence
has
shown
seemingly
contradictory
effects
on
visual
perception
and
working
memory.
While
serial
promotes
perpetual
mnemonic
stability,
it
biases
behavioral
reports
toward
prior
information.
The
neural
mechanisms
that
drive
both
biasing
adaptive
stabilizing
are
not
well
understood.
We
proposed
tested
a
reactivation
integration
mechanism
can
account
for
these
effects.
used
multivariate
pattern
analyses
of
EEG
data
(26
human
participants,
17
females,
9
males)
to
examine
the
reported
orientation
during
delay
period
memory
task.
strength
reports,
but
sensory
items,
was
predictive
magnitude
dependency
biases.
These
reactivated
representations
integrated
with
representation
current
item
improved
ability
decode
contents
Overall,
our
provide
convergent
evidence
suggesting
in
task
subsequent
trial
become
representations.
This
similarity-dependent
drives
report
stabilization
attributed
Язык: Английский
Discrimination of mnemonic similarity is associated with short-term and long-term memory precision
Memory & Cognition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 21, 2024
Язык: Английский
An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function
Molecular Psychiatry,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
Язык: Английский
Discrimination of Mnemonic Similarity is Associated with Short-term and Long-term Memory Precision
Опубликована: Янв. 10, 2024
Remembering
specific
memories
with
precision
relies
on
the
differentiation
of
similar
memory
contents
—
a
process
commonly
referred
to
as
pattern
separation
and
behaviorally
operationalized
lure
discrimination
in
mnemonic
similarity
task.
Although
is
typically
investigated
context
long-term
(LTM),
recent
research
extends
these
findings
short-term
(STM)
within
mixture
model
framework,
emphasizing
distinction
between
quality
quantity.
According
this
associated
across
STM
LTM,
regardless
overall
likelihood.
However,
associations
among
measures
may
persist
without
assumption.
In
an
alternative
model,
unitary
strength
measure
quantified
score
(d’)
also
capture
association
quality,
has
been
previously
linked
strength-based
performance.
We
tested
possibilities
based
individual
differences
132
participants
who
underwent
tasks
measuring
STM/LTM
quality.
find
that
behavioral
estimates
are
significantly
correlated
irrespective
likelihood
recall
success.
absent
when
considering
correlation
under
framework.
By
leveraging
constrain
our
understanding
cognitive
models,
data
unravel
intricate
relationship
timescales.
These
therefore
contribute
identifying
sensitive
for
detecting
subtle
deficits
aging/clinical
populations.
Язык: Английский
Neurocognitive Dynamics and Behavioral Differences of Symmetry and Asymmetry Processing in Working Memory: Insights from fNIRS
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 20, 2024
Abstract
Symmetry
is
a
ubiquitous
property
of
the
visual
world.
It
facilitates
cognitive
processing
and
fosters
aesthetic
appeal.
Despite
its
importance
to
experience
perceptual
prominence,
integration
symmetry
in
working
memory
remains
underexplored.
In
our
study,
participants
engaged
delayed
matching
sample
task
involving
both
symmetrical
asymmetrical
stimuli,
while
their
brain
activity
was
monitored
using
functional
Near
Infrared
Spectroscopy
(fNIRS).
The
study
revealed
that
significantly
enhances
performance.
improves
performance,
with
stimuli
leading
higher
accuracy
faster
recall
than
ones,
especially
under
high
load.
This
effect
varies
type
symmetry,
diagonal
being
most
effective.
Neuroimaging
data
showed
distinct
activation
patterns
when
processed
particularly
memory-straining
condition.
Significant
differences
were
observed
various
regions,
lateral
occipital,
posterior
parietal,
medial
dorsolateral
prefrontal
cortices
reacting
decreased
oxygenated
hemoglobin
(HbO),
left
orbitofrontal
(HbO)
right
ventrolateral
cortex
(HbO
HbR)
concentration
increased.
Overall,
findings
highlight
complex,
region-specific
response
emphasizing
nuanced
role
during
tasks
potential
implication
for
creative
thinking.
Язык: Английский
Beyond routine maintenance: Current trends in working memory research
Опубликована: Авг. 22, 2024
Working
memory
is
an
evolving
concept.
Our
understanding
of
the
neural
functions
that
support
WM
develops
iteratively
alongside
approaches
used
to
study
it,
and
both
can
be
profoundly
shaped
by
available
tools
prevailing
theoretical
paradigms.
Here,
organizers
2024
Memory
Symposium
–
inspired
this
year’s
meeting
highlight
current
trends
looming
questions
in
working
research.
Язык: Английский
Transcranial Direct Current Stimulation Over Bilateral Temporal Lobes Modulates Hippocampal‐Occipital Functional Connectivity and Visual Short‐Term Memory Precision
Weizhen Xie,
Sanikaa Thakurdesai,
Sahereh Varastegan
и другие.
Hippocampus,
Год журнала:
2024,
Номер
35(1)
Опубликована: Дек. 22, 2024
ABSTRACT
Although
the
medial
temporal
lobe
(MTL)
is
traditionally
considered
a
region
dedicated
to
long‐term
memory,
recent
neuroimaging
and
intracranial
recording
evidence
suggests
that
MTL
also
contributes
certain
aspects
of
visual
short‐term
memory
(VSTM),
such
as
quality
or
precision
retained
VSTM
content.
This
study
aims
further
investigate
MTL's
role
in
through
application
transcranial
direct
current
stimulation
(tDCS)
functional
magnetic
resonance
imaging
(fMRI).
Participants
underwent
1.5
mA
offline
tDCS
over
bilateral
lobes
using
left
cathodal
right
anodal
electrodes,
administered
for
either
20
min
(active)
0.5
within
20‐min
window
(sham),
counterbalanced
design.
As
electrical
passes
midbrain
structures
with
this
montage,
prior
behavioral
modeling
protocol
can
modulate
functions.
To
confirm
examine
its
impacts
on
VSTM,
participants
completed
color
recall
task
immediately
following
tDCS,
while
undergoing
fMRI
scan
subsequent
7.5‐min
resting‐state
scan,
during
which
they
focused
fixation
cross.
Behavioral
results
indicated
decreased
without
significantly
affecting
overall
success.
Furthermore,
psychophysiological
interaction
analysis
revealed
modulated
hippocampal‐occipital
connectivity
task,
despite
no
main
effect
BOLD
activity.
Notably,
modulation
was
observed
15–20
post‐tDCS,
magnitude
correlating
participants'
changes
across
active
control
conditions.
Combined,
these
findings
suggest
intrinsic
between
sensory
areas,
thereby
precision.
Язык: Английский
Eye movements organize excitability state, information coding and network connectivity in the human hippocampus
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Natural
vision
is
an
active
sensing
process
that
entails
frequent
eye
movements
to
sample
the
environment.
Nonetheless
often
studied
using
passive
viewing
with
position
held
constant.
Using
closed-loop
eye-tracking,
saccade-contingent
stimulation
and
simultaneous
intracranial
recordings
in
surgical
epilepsy
patients,
we
tested
critical
role
of
movement
signals
during
natural
visual
processing
hippocampus
hippocampal-amygdala
circuit.
Prior
work
shows
saccades
elicit
phase
reset
ongoing
neural
excitability
fluctuations
across
a
broad
array
cortical
subcortical
areas.
Here
show
saccade-related
systematically
modulates
neuronal
ensemble
responses
input,
enables
phase-coding
information
saccade-fixation
cycle
network
connectivity
between
amygdala.
The
thus
emerges
as
fundamental
sampling
unit,
organizing
range
operations
including
input
representation,
coding.
One-Sentence
Summary
Saccade-fixation
cycle:
coding
activation
Язык: Английский