Respiration shapes response speed and accuracy with a systematic time lag

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 292(2044)

Опубликована: Апрель 1, 2025

Sensory–cognitive functions are intertwined with physiological processes such as the heart beat or respiration. For example, we tend to align our respiratory cycle expected events actions. This happens during sports but also in computer-based tasks and systematically structures phase around relevant events. However, studies show that trial-by-trial variations shape brain activity speed accuracy of individual responses. We both phenomena—the alignment respiration explanatory power on behaviour—co-exist. In fact, average an relative experimental trials trial-to-trial hold significant predictive behavioural performance, particular for reaction times. co-modulation behaviour emerges regardless whether generally breathes faster slower is strongest about 2 s prior participant’s The persistence these effects across 12 datasets 277 participants performing sensory–cognitive confirms robustness results, suggests a profound time-lagged influence structured sensory–motor

Язык: Английский

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Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice

Neurobiology of Disease, Год журнала: 2024, Номер 192, С. 106422 - 106422

Опубликована: Янв. 28, 2024

Gait ataxia is one of the most common and impactful consequences cerebellar dysfunction. Purkinje cells, sole output neurons cortex, are often involved in underlying pathology, but their specific functions during locomotor control health disease remain obfuscated. We aimed to describe effect gradual adult-onset cell degeneration on gaiting patterns mice, determine whether two different mechanisms that both lead cause development gait ataxia. Using ErasmusLadder together with a newly developed limb detection algorithm machine learning-based classification, we subjected mice challenging task detailed analysis single parameters, intralimb coordination whole-body movement. tested cell-specific mouse models, involving stochastic death due impaired DNA repair (Pcp2-Ercc1−/−), other carrying mutation causes spinocerebellar type 1 (Pcp2-ATXN1[82Q]). Both models showed progressive deficits, sequence which parameters deteriorated was between lines. Our longitudinal approach revealed loss function can complex pattern over time, this depends specifics pathological involved. hypothesize variability will also be present progression patients, our findings facilitate study therapeutic interventions as subtle changes abilities quantified by methods.

Язык: Английский

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Circuit formation and sensory perception in the mouse olfactory system

Frontiers in Neural Circuits, Год журнала: 2024, Номер 18

Опубликована: Фев. 16, 2024

In the mouse olfactory system, odor information is converted to a topographic map of activated glomeruli in bulb (OB). Although arrangement genetically determined, glomerular structure plastic and can be modified by environmental stimuli. If pups are exposed particular odorant, responding become larger recruiting dendrites connecting projection neurons interneurons. This imprinting not only increases sensitivity odor, but also imposes positive quality on imprinted memory. External represented as an OB transmitted cortex (OC) amygdala for decision making elicit emotional behavioral outputs using two distinct neural pathways, innate learned. Innate circuits start work right after birth, whereas learned functional later on. this paper, recent progress will summarized study circuit formation perception mice. We propose new hypotheses timing gating activity relation respiration cycle.

Язык: Английский

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Neuroimmune recognition and regulation in the respiratory system

European Respiratory Review, Год журнала: 2024, Номер 33(172), С. 240008 - 240008

Опубликована: Апрель 30, 2024

Neuroimmune recognition and regulation in the respiratory system is a complex highly coordinated process involving interactions between nervous immune systems to detect respond pathogens, pollutants other potential hazards tract. This interaction helps maintain health integrity of system. Therefore, understanding critical maintaining lung developing treatments for diseases. In this review, we summarise projection distribution different types neurons (trigeminal nerve, glossopharyngeal vagus spinal dorsal root sympathetic nerve) We also introduce several cells epithelium that closely interact with nerves (pulmonary neuroendocrine cells, brush solitary chemosensory tastebuds). These are primarily located at key positions tract, where project them, forming neuroepithelial units, thus enhancing ability neural recognition. Furthermore, roles played by these sensing or responding specific pathogens (influenza, severe acute syndrome coronavirus 2, syncytial virus, human metapneumovirus, herpes viruses, Sendai parainfluenza

Язык: Английский

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Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing

Open Access Rheumatology Research and Reviews, Год журнала: 2024, Номер Volume 16, С. 55 - 66

Опубликована: Март 1, 2024

The classification of fibromyalgia (FM) is not always immediate and simple, with the time from first diagnosis, compared to onset symptoms, a few years. Currently, we do have instrumental or biochemical tests considered as gold standards; clinician will make diagnosis FM based on patient's medical history subjective assessment. symptoms can involve physical, cognitive psychological disorders, presence pain different origins classifications: nociplastic, nociceptive neuropathic pain. Among highlighted, postural disorders neuromotor uncoordination emerge, whose functional dysfunctions increase mortality morbidity rate. An alteration diaphragm muscle could generate such motor problems. Considering that current literature underestimates importance breathing in FM, article aims highlight relationship between diaphragmatic difficulties patient, soliciting new points view for clinical therapeutic framework.

Язык: Английский

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Low- and high-level coordination of orofacial motor actions

Current Opinion in Neurobiology, Год журнала: 2023, Номер 83, С. 102784 - 102784

Опубликована: Сен. 25, 2023

Язык: Английский

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Peculiarities of cardio-respiratory relationships in qualified athletes with different types of heart rhythm regulation according to respiratory maneuver data

Frontiers in Sports and Active Living, Год журнала: 2025, Номер 6

Опубликована: Янв. 13, 2025

Our goal was to determine the differences in changes cardiovascular and cardiorespiratory interaction indicators during a respiratory maneuver with change breathing rate athletes different types of heart regulation. The results study 183 healthy men aged 21.2 ± 2.3 years, who were systematically involved various sports, analyzed. According analysis HRV spontaneous breathing, divided into 4 groups taking account type regulation (HRR). Group 1 (with I) consisted 53 people, group 2 II)-29 3 III)-85 IV)-16 people. methodology for studying system included combined measurements activity sitting position using spiroarteriocardiorhythmograph. duration 6 min. controlled frequency 15 per minute (CR6 CR15), it is shown that pronounced predominance parasympathetic influences (type IV) conditions excessive control moderate hyperventilation, arterial baroreflex sensitivity (δBRLF δBRHF) are noted comparison other HRR. Athletes IV at CR6 δBRLF significantly differ from III (p = 0.026) do not II 0.141). In δBRHF 0.038 p 0.043)-from I II. It sympathetic (types II), reactivity BRS response hyperventilation (CR15) lower. Changes Hildebrandt index volume synchronization additionally differentiate HRR associated influences. use current showed informativeness differentiation states functional overstrain.

Язык: Английский

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The multifunctionality of the brainstem breathing control circuit

Current Opinion in Neurobiology, Год журнала: 2025, Номер 90, С. 102974 - 102974

Опубликована: Янв. 28, 2025

Subconscious breathing is generated by a network of brainstem nodes with varying purposes, like pacing or patterning certain breath phase. Decades anatomy, pharmacology, and physiology studies have identified characterized the system's fundamental properties that produce robust breathing, we now well-conceived computational models are based on detailed descriptions neuronal connectivity, biophysical properties, functions in breathing. In total, considerable understanding control circuit. But, last five years, utilization molecular genetic approaches to study neural subtypes within each node has led new era circuit research explains how integrated more complex behaviors speaking running connected other physiological systems our state-of-mind. This review will describe basic role key components then highlight transformative discoveries broaden these brain areas. These serve illustrate creativity exciting future research.

Язык: Английский

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Paced Breathing Associated With Pupil Diameter Oscillations at the Same Rate and Reduced Lapses in Attention

Psychophysiology, Год журнала: 2025, Номер 62(2)

Опубликована: Фев. 1, 2025

ABSTRACT A dynamical systems model proposes that respiratory, locus coeruleus—noradrenaline (LC‐NA), and cortical attentional interact, producing emergent states of attention. We tested a prediction fixing respiratory pace (versus spontaneous respiration) stabilizes oscillations in pupil diameter (LC‐NA proxy) state. Primary comparisons were between ‘Instructed Breath’ (IB) ‘No Instructed (NIB) groups. Secondarily, we investigated the effects shifting frequency IB group from 0.15 to 0.1–0.15 Hz Experiment 1 ( n = 55) 0.15–0.1 only 2 48) (replication). In Paced Auditory Cue Entrainment (PACE) task, participants heard two auditory tones, alternating higher lower pitches, cycling continuously. Tones acted as breath guide for an attention monitor both Participants gave rhythmic mouse responses transition points tones (left high‐to‐low, right low‐to‐high). derived accuracy click timing (RTm), variability (RTVL), counts erroneously inverting left/right rhythm (IRs Switches). Despite no differences groups RTm or RTVL, committed significantly fewer IRs switches, indicating less lapses during paced breathing. Differences behavioral metrics present across tone cycle frequencies but not exclusive IB, so did appear have specific effect. Pupil closely tracked instructed breathing, implicating LC‐NA activity being entrained by intervention. conclude pacing stabilize attention, possibly through stabilizing fluctuations LC‐NA.

Язык: Английский

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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. This the first study to use MRI follow functional changes in brain activity response different doses of psilocybin fully awake, drug naive rats. Female male rats were given IP injections vehicle or 0.03 mg/kg, 0.3 3.0 mg/kg while awake during imaging session. Changes BOLD signal recorded over 20 min window. Data for resting state connectivity collected approximately 35 post injection All data registered rat 3D atlas 173 regions providing site-specific global connectivity. Treatment resulted significant dose-dependent increase positive signal. The areas most affected by acute presentation somatosensory cortex, basal ganglia thalamus. Females significantly more sensitive dose than males. There was connectivity, highlighted hyperconnectivity cerebellum. Brain hypothesized be involved loss sensory filtering organization motor stimuli such as claustrum cortico-basal ganglia-thalamic-cortical loop all manner. Indeed, general neuroanatomical circuitry associated psychedelic experience but direction pattern between neural networks inconsistent human literature.

Язык: Английский

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