Heterogeneous Synaptic Homeostasis: A Novel Mechanism Boosting Information Propagation in Neural Circuitry DOI Creative Commons
Farhad Razi, Belén Sancristóbal

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 5, 2023

Perceptual awareness of auditory stimuli decreases from wake-fulness to sleep, largely due reduced cortical responsiveness. During wakefulness, neural responses external exhibit a broader spatiotemporal propagation pattern compared deep sleep. A potential mechanism for this phenomenon is the synaptic upscaling excitatory connections during as posited by homeostasis hypothesis. However, we argue that uniform alone cannot fully account observation. We propose novel suggesting between different areas exceeds within individual wakefulness. Our computational results demonstrate former promotes transfer and information, whereas latter has diminishing effects. These findings highlight necessity heterogeneous suggest presence heterogeneity in receptor expression neuromodulators involved modulation along dendrite.

Язык: Английский

Consciousness and sleep DOI
Giulio Tononi, Mélanie Boly, Chiara Cirelli

и другие.

Neuron, Год журнала: 2024, Номер 112(10), С. 1568 - 1594

Опубликована: Май 1, 2024

Язык: Английский

Процитировано

20
Thalamic contributions to the state and contents of consciousness DOI Creative Commons
Christopher J. Whyte, Michelle J. Redinbaugh, James M. Shine

и другие.

Neuron, Год журнала: 2024, Номер 112(10), С. 1611 - 1625

Опубликована: Май 1, 2024

Consciousness can be conceptualized as varying along at least two dimensions: the global state of consciousness and content conscious experience. Here, we highlight cellular systems-level contributions thalamus to then argue for thalamic content, including integrated, segregated, continuous nature our We underscore vital, yet distinct roles core- matrix-type neurons. Through reciprocal interactions with deep-layer cortical neurons, matrix neurons support wakefulness determine perceptual thresholds, whereas core maintain enable constancy. further propose that integration, segregation, continuity depend on convergent corticothalamic projections enabling dimensionality reduction, a reticular nucleus-mediated divisive normalization-like process, sustained coherent activity in thalamocortical loops, respectively. Overall, conclude plays central topological role brain structures controlling

Язык: Английский

Процитировано

20
Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation DOI Creative Commons
Karthik Kumaravelu, Warren M. Grill

Brain stimulation, Год журнала: 2024, Номер 17(2), С. 365 - 381

Опубликована: Март 1, 2024

Background:Intracortical microstimulation (ICMS) is used to map neuronal circuitry in the brain and restore lost sensory function, including vision, hearing, somatosensation. The temporal response of cortical neurons single pulse ICMS remarkably stereotyped comprises short latency excitation followed by prolonged inhibition and, some cases, rebound excitation. However, neural origin different components are poorly understood, interactions between three during trains pulses remains unclear.Objective:We computational modeling determine mechanisms contributing model neurons.Methods:We implemented a biophysically based column comprising with realistic morphology synapses quantified protocols. We characterized responses across stimulation intensities inhibitory (GABA-B/GABA-A) synaptic strengths. To probe components, we paired at inter-pulse intervals frequencies. Finally, evaluated performance biomimetic evoking sustained responses.Results:Single evoked period inhibition, but did not exhibit post-inhibitory strength increased duration amplitude. Prolonged resulted from both after-hyperpolarization currents GABA-B transmission. During protocol, test decreased marginally compared those for interpulse (IPI) < 100 ms. Further, was IPIs <50ms predicted linear superposition individual responses. For IPIs>50 ms, comparable pulse. Short repetitive excitatory against background inhibition. declined higher cessation frequencies following Biomimetic onset offset phases despite presence induced inhibition.Conclusions:The replicated long-lasting documented experimental studies ICMS. Both cellular influenced generated non-linear dynamic ICMS-evoked activity may play an important role mediating ICMS-induced precepts.

Язык: Английский

Процитировано

8
Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand DOI Open Access

Daniela Piña Novo,

Mang Gao,

Jianing Yu

и другие.

Опубликована: Янв. 31, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical same system. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Response amplitudes strongly attenuated approximately a third those S1. Responses typically triphasic, with suppression rebound following initial peak. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three-quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. These results provide quantitative measures hand/forelimb-related transcortical loop; demonstrate prominent mechanistic role neurons phase response; and, support conceptual model which signals reach via high-speed subcortical generate characteristic activity, densely polysynaptic corticocortical similar but delayed profile activity.

Язык: Английский

Процитировано

0
Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand DOI Open Access

Daniela Piña Novo,

Mang Gao,

Jianing Yu

и другие.

Опубликована: Янв. 31, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical same system. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Response amplitudes strongly attenuated approximately a third those S1. Responses typically triphasic, with suppression rebound following initial peak. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three-quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. These results provide quantitative measures hand/forelimb-related transcortical loop; demonstrate prominent mechanistic role neurons phase response; and, support conceptual model which signals reach via high-speed subcortical generate characteristic activity, densely polysynaptic corticocortical similar but delayed profile activity.

Язык: Английский

Процитировано

0
Rapid and cumulative adult plasticity in the mouse visual cortex DOI Creative Commons
Hiroyuki Miyamoto,

Emi Mazaki,

Yuichi Makino

и другие.

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Фев. 28, 2025

Experience-dependent neural plasticity enables the brain to adapt diverse and dynamic environments by reshaping circuits. In adult visual system, this can be elicited repeated sensory stimuli; however, its temporal dynamics underlying mechanisms remain unclear. Here, we investigated regulation of response potentiation induced light flashes in primary cortex awake mice. Our findings revealed two distinct phases potentiation: a rapid phase occurring within seconds cumulative developing over hours days. Notably, identification phenomenon adds refines prevailing view that is predominantly slow. Additionally, exposure stimuli enhanced spontaneous slow-wave activity during non-REM sleep. This was significantly impaired Grin2a (NR2A) knockout mice, model schizophrenia, which mirrors deficits observed human patients. The dual characteristics flash-evoked likely reflect multifaceted aspects functionality, encompassing processes related memory, learning, neurological disorders. defined circuits provides simplified yet robust extensible framework for exploring adaptive maladaptive behavioral changes.

Язык: Английский

Процитировано

0
Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans DOI Creative Commons
Simone Russo, Leslie D. Claar,

Giulia Furregoni

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 16, 2025

Cortical stimulation with single pulses is a common technique in clinical practice and research. However, we still do not understand the extent to which it engages subcortical circuits that may contribute associated evoked potentials (EPs). Here show cortical generates remarkably similar EPs humans mice, late component similarly modulated by state of targeted cortico-thalamic network. We then optogenetically dissect underlying circuit demonstrating caused thalamic hyperpolarization rebound. The magnitude this correlates bursting frequency synchronicity neurons, subject's behavioral state. A simulation thalamo-cortical highlights both intrinsic currents as well GABAergic neurons response profile. conclude pulse cortico-thalamo-cortical largely preserved across different species modalities.

Язык: Английский

Процитировано

0
Investigating visuo-tactile mirror properties in borderline personality disorder: A TMS-EEG study DOI Creative Commons
Agnese Zazio,

Cora Miranda Lanza,

Antonietta Stango

и другие.

Clinical Neurophysiology, Год журнала: 2024, Номер 168, С. 139 - 152

Опубликована: Ноя. 6, 2024

Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., Tactile Mirror System (TaMS). Here, we aimed to shed light on TaMS and empathic deficits pw-BPD focusing connectivity, using transcranial magnetic stimulation electroencephalography (TMS-EEG).

Язык: Английский

Процитировано

2
Active cortical networks promote shunting fast synaptic inhibition in vivo DOI Creative Commons
Richard J. Burman, Paul J. N. Brodersen, Joseph V. Raimondo

и другие.

Neuron, Год журнала: 2023, Номер 111(22), С. 3531 - 3540.e6

Опубликована: Сен. 1, 2023

Fast synaptic inhibition determines neuronal response properties in the mammalian brain and is mediated by chloride-permeable ionotropic GABA-A receptors (GABAARs). Despite their fundamental role, it still not known how GABAARs signal intact brain. Here, we use vivo gramicidin recordings to investigate GABAAR signaling mouse cortical pyramidal neurons under conditions that preserve native transmembrane chloride gradients. In anesthetized cortex, exert classic hyperpolarizing effects. contrast, GABAAR-mediated awake cortex found be predominantly shunting. This due more depolarized equilibrium potentials (EGABAAR), which are shown result from high levels of activity characterize networks. Synaptic EGABAAR observed facilitates desynchronizing effects inhibitory inputs upon local networks, increases flexibility spiking responses external inputs. Our findings therefore suggest adapts optimize functions.

Язык: Английский

Процитировано

5
Laminar evoked responses in mouse somatosensory cortex suggest a special role for deep layers in cortical complexity DOI Creative Commons
Christoph Hönigsperger, Johan F. Storm, Alessandro Arena

и другие.

European Journal of Neuroscience, Год журнала: 2023, Номер 59(5), С. 752 - 770

Опубликована: Авг. 16, 2023

Abstract It has been suggested that consciousness is closely related to the complexity of brain. The perturbational index (PCI) used in humans and rodents distinguish conscious from unconscious states based on global cortical responses (recorded by electroencephalography, EEG) local stimulation (CS). However, it unclear how different layers respond CS contribute resulting intra‐ inter‐areal connectivity PCI. A detailed investigation dynamics needed understand basis for We hypothesized level correlates with layer‐specific activity connectivity. tested this idea measuring somatosensory cortex (S1) mice, combining electrical deep motor cortex, electrocorticography (ECoG) laminar recordings 1–6 S1, during wakefulness general anaesthesia (sevoflurane). found transition wake sevoflurane correlated a drop both PCI (PCI st ) values (complexity). This was accompanied decrease neural firing rate, spike‐field coherence long‐range functional specific (L5, L6). Our results suggest are mechanistically important changes thereby state consciousness.

Язык: Английский

Процитировано

4