Dietary acrylamide disrupts the functioning of the biological clock DOI Creative Commons
Jolanta Górska‐Andrzejak,

Lucyna Widacha,

Robert Wadowski

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 134912 - 134912

Опубликована: Июнь 13, 2024

Acrylamide (ACR) is a known carcinogen and neurotoxin. It chronically consumed in carbohydrate-rich snacks processed at high temperatures. This calls for systematic research into the effects of ACR intake, best performed an experimental model capable detecting symptoms its neurotoxicity both low doses. Here, we study influence 10 µg/g (corresponding to concentrations found food products) and, comparison, 60, 80 110 dietary ACR, on fruit fly Drosophila melanogaster. We show that chronic administration affects lifespan, activity level most importantly, daily circadian pattern locomotor Drosophila. ACR-treated flies well-defined concentration-dependent neurotoxicity; reduced anticipation upcoming changes light conditions increased arrhythmicity constant darkness. The results suggest rhythm-generating neural circuits their oscillator (biological clock) are sensitive even if exposure time sufficiently long. makes behavioural readout clock, rhythm activity, useful tool studying adverse probably other compounds.

Язык: Английский

Dietary acrylamide disrupts the functioning of the biological clock DOI Creative Commons
Jolanta Górska‐Andrzejak,

Lucyna Widacha,

Robert Wadowski

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 134912 - 134912

Опубликована: Июнь 13, 2024

Acrylamide (ACR) is a known carcinogen and neurotoxin. It chronically consumed in carbohydrate-rich snacks processed at high temperatures. This calls for systematic research into the effects of ACR intake, best performed an experimental model capable detecting symptoms its neurotoxicity both low doses. Here, we study influence 10 µg/g (corresponding to concentrations found food products) and, comparison, 60, 80 110 dietary ACR, on fruit fly Drosophila melanogaster. We show that chronic administration affects lifespan, activity level most importantly, daily circadian pattern locomotor Drosophila. ACR-treated flies well-defined concentration-dependent neurotoxicity; reduced anticipation upcoming changes light conditions increased arrhythmicity constant darkness. The results suggest rhythm-generating neural circuits their oscillator (biological clock) are sensitive even if exposure time sufficiently long. makes behavioural readout clock, rhythm activity, useful tool studying adverse probably other compounds.

Язык: Английский

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