Genotype × environment interactions in gene regulation and complex traits
Nature Genetics,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 1, 2024
Язык: Английский
Metaboloepigenetics: Role in the Regulation of Flow-Mediated Endothelial (Dys)Function and Atherosclerosis
Cells,
Год журнала:
2025,
Номер
14(5), С. 378 - 378
Опубликована: Март 5, 2025
Endothelial
dysfunction
is
the
main
initiating
factor
in
atherosclerosis.
Through
mechanotransduction,
shear
stress
regulates
endothelial
cell
function
both
homeostatic
and
diseased
states.
Accumulating
evidence
reveals
that
epigenetic
changes
play
critical
roles
etiology
of
cardiovascular
diseases,
including
The
metabolic
regulation
epigenetics
has
emerged
as
an
important
control
gene
expression
states,
but
to
best
our
knowledge,
this
connection
remains
largely
unexplored
In
review,
we
(1)
summarize
how
(or
flow)
(dys)function;
(2)
explore
alterations
occur
endothelium
response
disturbed
flow;
(3)
review
metabolism
under
different
conditions;
(4)
suggest
mechanisms
which
may
link
altered
epigenome
by
modulations
metabolite
availability.
We
believe
plays
role
reprogramming
could
pave
way
for
novel
metabolism-based
therapeutic
strategies.
Язык: Английский
Molecular insights into trauma: A framework of epigenetic pathways to resilience through intervention
Med,
Год журнала:
2024,
Номер
unknown, С. 100560 - 100560
Опубликована: Дек. 1, 2024
Язык: Английский
Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 30, 2023
Abstract
The
epigenomic
landscape
of
human
immune
cells
is
dynamically
shaped
by
both
genetic
factors
and
environmental
exposures.
However,
the
relative
contributions
these
elements
are
still
not
fully
understood.
In
this
study,
we
employed
single-nucleus
methylation
sequencing
ATAC-seq
to
systematically
explore
how
pathogen
chemical
exposures,
along
with
variation,
influence
cell
epigenome.
We
identified
distinct
exposure-associated
differentially
methylated
regions
(eDMRs)
corresponding
each
exposure,
revealing
remodel
methylome,
alter
states,
affect
transcription
factor
binding.
Furthermore,
observed
a
significant
correlation
between
changes
in
DNA
chromatin
accessibility,
underscoring
coordinated
response
also
uncovered
genotype-associated
DMRs
(gDMRs),
demonstrating
that
while
eDMRs
enriched
regulatory
regions,
gDMRs
preferentially
located
gene
body
marks,
suggesting
exposures
exert
differential
control.
Notably,
disease-associated
SNPs
were
frequently
colocalized
meQTLs,
providing
new
cell-type-specific
insights
into
basis
disease.
Our
findings
underscore
intricate
interplay
sculpting
epigenome,
offering
deeper
understanding
function
regulated
health
Язык: Английский
Changes in Gene Expression Related to Atopic Dermatitis in Mothers and Infants Following VOC Exposure
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12827 - 12827
Опубликована: Ноя. 28, 2024
Environmental
pollutants,
particularly
volatile
organic
compounds
(VOCs),
are
associated
with
various
diseases,
including
atopic
dermatitis
(AD).
However,
despite
numerous
studies
on
AD,
there
is
a
lack
of
research
the
impact
environmental
exposures
mothers
and
infants.
This
study,
therefore,
investigated
effects
maternal
exposure
to
specific
VOCs
(toluene,
xylene,
benzene)
expression
AD-related
genes
in
their
RNA
levels
DNA
methylation
patterns
were
analyzed
examine
correlation
between
AD.
A
multi-omics
approach
integrating
gene
data
was
additionally
employed
gain
broader
understanding
genetic
VOC
exposure.
Network
analysis
revealed
significant
changes
For
example,
toluene
resulted
upregulation
AQP10,
which
linked
keratinocyte
dysfunction,
infants,
IL31RA
CCL20
notably
affected,
both
play
critical
roles
immune
response
skin
barrier
function.
In
exposed
histamine
receptor
HRH1
identified
as
key
player
influencing
AD
through
its
role
recovery,
while
infants
exhibited
consistent
network
responses
downregulation
TIGIT,
reflecting
shared
across
different
xylene
isomers.
Interestingly,
isomers
displayed
nearly
identical
patterns,
suggesting
developmental
resistance
diverse
factors.
No
benzene-exposed
group.
These
findings
suggest
that
may
have
related
highlighting
complexity
how
factors
contribute
disease
development.
Язык: Английский