Astrocytic GAT‐3 Regulates Synaptic Transmission and Memory Formation in the Dentate Gyrus

Glia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

GABAergic network activity plays a crucial role in wide array of physiological processes and is implicated various pathological conditions. While extensive research has been conducted on how modulates both excitatory inhibitory synaptic transmission the CA1 region, mechanisms by which it influences entorhinal cortex-dentate gyrus (EC-DG) circuits are still largely unexplored. Using combination whole-cell patch-clamp recordings, optogenetics, immunohistochemistry, behavioral assays, we demonstrate that activation GABA transporter 3 (GAT-3) astrocytes triggers an increase intracellular Ca

Язык: Английский

Astrocytic calcium signals modulate exercise-induced fatigue in mice

Neuroscience, Год журнала: 2024, Номер 564, С. 306 - 318

Опубликована: Ноя. 17, 2024

Язык: Английский