Notch signaling and Bsh homeodomain activity are integrated to diversifyDrosophilalamina neuron types DOI Creative Commons
Chundi Xu,

Tyler B. Ramos,

Owen J. Marshall

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 15, 2023

Abstract Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in contexts remains elusive. In our accompanying paper, using the Drosophila lamina neuron types (L1-L5) as a model, we show that primary homeodomain transcription factor (HDTF) Bsh activates secondary HDTFs Ap (L4) and Pdm3 (L5) L4/L5 fates. Here test hypothesis enables to differentially specify L4 L5 We asymmetric between newborn neurons, but they are not siblings; rather, due Delta expression adjacent L1 neurons. While mutually independent, necessary sufficient fate over L5. The ON L4, compared OFF L5, has distinct open chromatin landscape which allows bind genomic loci, leading L4-specific identity gene transcription. propose novel model integrated with HDTF activity diversify by directly or indirectly generating constrains pool of genes can activate.

Язык: Английский

Notch signaling and Bsh homeodomain activity are integrated to diversifyDrosophilalamina neuron types DOI Creative Commons
Chundi Xu,

Tyler B. Ramos,

Owen J. Marshall

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 15, 2023

Abstract Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in contexts remains elusive. In our accompanying paper, using the Drosophila lamina neuron types (L1-L5) as a model, we show that primary homeodomain transcription factor (HDTF) Bsh activates secondary HDTFs Ap (L4) and Pdm3 (L5) L4/L5 fates. Here test hypothesis enables to differentially specify L4 L5 We asymmetric between newborn neurons, but they are not siblings; rather, due Delta expression adjacent L1 neurons. While mutually independent, necessary sufficient fate over L5. The ON L4, compared OFF L5, has distinct open chromatin landscape which allows bind genomic loci, leading L4-specific identity gene transcription. propose novel model integrated with HDTF activity diversify by directly or indirectly generating constrains pool of genes can activate.

Язык: Английский

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