Lateral frontoparietal functional connectivity based on individual sulcal morphology DOI Creative Commons
Suvi Häkkinen, Willa I. Voorhies, Ethan H. Willbrand

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 18, 2024

Abstract A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there mounting evidence that sulcal morphology relevant to functional architecture cognition. However, our understanding relationships between anatomy, activity, behavior still in infancy. We previously found depth three small, shallow sulci lateral prefrontal cortex (LPFC) was linked reasoning performance childhood adolescence (Voorhies et al., 2021). These findings beg question: what linking mechanism cognition? To shed light on this question, we investigated connectivity among LPFC parietal (LPC). leveraged manual parcellations (21 sulci/hemisphere, total 1806) magnetic resonance (fMRI) data from a task 43 participants aged 7–18 years (20 female). conducted clustering classification analyses individual- level sulci. Broadly, 1) patterns individual could be differentiated – more accurately than rotated labels equated for size shape; 2) did not consistently correspond with probabilistic or large-scale networks; 3) clustered together into groups similar patterns, dictated by spatial proximity; 4) across individuals, greater associated higher network centrality several under investigation. results highlight can meaningfully anchored demonstrate vary as function depth. Significance Statement salient, behaviorally relevant, folding. links anatomy are poorly understood particularly shallow, individually variable association cortices. Here, focusing defined regions, offer novel, anatomically informed approach defining connectomes. Further, demonstrate, first time, link morphology.

Язык: Английский

Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity DOI Creative Commons
Ethan H. Willbrand, Samira A. Maboudian, Matthew Elliott

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Background Impulsivity is a multidimensional construct reflecting poor constraint over one’s behaviors. Clinical psychology research identifies separable impulsivity dimensions that are each unique transdiagnostic indicators for psychopathology. Yet, despite this apparent clinical importance, the shared and neuroanatomical correlates of these factors remain largely unknown. Concomitantly, neuroimaging variably present human brain structures implicated in cognition disorder: folds (sulci) cerebral cortex located latest developing most evolutionarily expanded hominoid-specific association cortices. Methods We tethered two fields to test whether variability one such structure anterior cingulate (ACC)—the paracingulate sulcus (PCGS)—was related individual differences trait impulsivity. 120 adult participants with internalizing or externalizing psychopathology completed magnetic resonance imaging scan Three-Factor Index. Using precision techniques, we manually identified PCGS, when present, acquired quantitative folding metrics (PCGS length ACC local gyrification index). Results Neuroanatomical-behavioral analyses revealed leftward symmetrical PCGS patterns had greater severity Lack Follow Through (LFT)—which captures inattention lack perseverance—than those rightward asymmetry. Neuroanatomical-functional co-localized focal locus found meta-analysis on feature underlying LFT. Both did not relate any dimension. Conclusions This study advances understanding establishes notion topographical organization distinct, cortical expanses underlie robust, implications

Язык: Английский

Процитировано

0
Lateral frontoparietal functional connectivity based on individual sulcal morphology DOI Creative Commons
Suvi Häkkinen, Willa I. Voorhies, Ethan H. Willbrand

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 18, 2024

Abstract A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there mounting evidence that sulcal morphology relevant to functional architecture cognition. However, our understanding relationships between anatomy, activity, behavior still in infancy. We previously found depth three small, shallow sulci lateral prefrontal cortex (LPFC) was linked reasoning performance childhood adolescence (Voorhies et al., 2021). These findings beg question: what linking mechanism cognition? To shed light on this question, we investigated connectivity among LPFC parietal (LPC). leveraged manual parcellations (21 sulci/hemisphere, total 1806) magnetic resonance (fMRI) data from a task 43 participants aged 7–18 years (20 female). conducted clustering classification analyses individual- level sulci. Broadly, 1) patterns individual could be differentiated – more accurately than rotated labels equated for size shape; 2) did not consistently correspond with probabilistic or large-scale networks; 3) clustered together into groups similar patterns, dictated by spatial proximity; 4) across individuals, greater associated higher network centrality several under investigation. results highlight can meaningfully anchored demonstrate vary as function depth. Significance Statement salient, behaviorally relevant, folding. links anatomy are poorly understood particularly shallow, individually variable association cortices. Here, focusing defined regions, offer novel, anatomically informed approach defining connectomes. Further, demonstrate, first time, link morphology.

Язык: Английский

Процитировано

0