Clinical trials targeting tau should be halted

Journal of Clinical Neuroscience, Год журнала: 2025, Номер 134, С. 111101 - 111101

Опубликована: Фев. 4, 2025

Язык: Английский

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Microglia: roles and genetic risk in Parkinson’s disease

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Ноя. 1, 2024

The prevalence of neurodegenerative disorders such as Parkinson's disease are increasing world populations age. Despite this growing public health concern, the precise molecular and cellular mechanisms that culminate in neurodegeneration remain unclear. Effective treatment options for other very limited, due part to uncertain etiology. One commonality across diseases is sustained neuroinflammation, mediated large by microglia, innate immune cells brain. Initially thought simply react neuron-derived pathology, genetic functional studies recent years suggest microglia play a more active role process than previously appreciated. Here, we review evidence roles pathogenesis progression, with particular focus on microglial functions perturbed associated genes mutations.

Язык: Английский

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Inferring Gene Regulatory Networks of ALS from Blood Transcriptome Profiles

Heliyon, Год журнала: 2024, Номер 10(23), С. e40696 - e40696

Опубликована: Ноя. 27, 2024

Язык: Английский

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Scopolamine animal model of memory impairment

Behavioural Brain Research, Год журнала: 2024, Номер unknown, С. 115344 - 115344

Опубликована: Ноя. 1, 2024

Язык: Английский

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