Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins DOI Open Access

Sriya Reddy Venati,

Vladimir N. Uversky

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8399 - 8399

Опубликована: Авг. 1, 2024

In this work, we explored the intrinsic disorder status of three members synuclein family proteins—α-, β-, and γ-synucleins—and showed that although all human synucleins are highly disordered, highest levels observed in γ-synuclein. Our analysis peculiarities amino acid sequences modeled 3D structures revealed pathological mutations A30P, E46K, H50Q, A53T, A53E associated with early onset Parkinson’s disease caused some increase local propensity α-synuclein. A comparative sequence-based proteins from various evolutionary distant species evaluation their using a set commonly used bioinformatics tools that, irrespective origin, analyzed study were predicted to be disordered proteins, indicating intrinsically nature represents an conserved therefore functionally important feature. detailed functional interactomes utilizing α-synuclein interactome has relatively higher as compared β- γ- relative γ-synuclein interactomes, interactors involved much broader spectrum diversified pathways. Although interacting characterized by functionalities, also common pathways, such synaptic vesicle cycle, serotonergic synapse, retrograde endocannabinoid signaling. Taken together, these observations highlight critical importance neuronal processes.

Язык: Английский

Epigenetics and Chromatin Remodeling DOI
H. Karimi Kinyamu, Dimitris Theofilatos, Lantz C. Mackey

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone DOI Creative Commons
Kazuto Kawamura,

Anna R. Diederich,

Birgit Gerisch

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Abstract Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa 1 . Shifts between fed fasted states activate ancient nutrient-sensing pathways which alter cellular epigenetic to promote longevity 2–4 Yet how age trajectories progress during fasting-refeeding, reprogram state remain largely unknown. Here we observe increases in predicted of Caenorhabditis elegans prolonged adult reproductive diapause, followed by extraordinary reduction refeeding. We identify hil-1 / H1-0 as an evolutionarily conserved nutrient-regulated linker histone mediates adaptations refeeding downstream FOXO TFEB transcription factors. In C. human cell culture, upregulation low-nutrient promotes long-term survival subsequent refeeding-induced recovery. Restoration after is improved enhancing the natural downregulation specifically Our study identifies HIL-1/H1.0 part ancestral switch that reprograms metabolic underlying resilience restoration.

Язык: Английский

Процитировано

0
The Evolving Role of Histone H1 in Shaping Chromatin and Epigenetic Landscapes DOI
Peng Liu,

Guisheng Zhou

Plant Science, Год журнала: 2025, Номер unknown, С. 112557 - 112557

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins DOI Open Access

Sriya Reddy Venati,

Vladimir N. Uversky

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8399 - 8399

Опубликована: Авг. 1, 2024

In this work, we explored the intrinsic disorder status of three members synuclein family proteins—α-, β-, and γ-synucleins—and showed that although all human synucleins are highly disordered, highest levels observed in γ-synuclein. Our analysis peculiarities amino acid sequences modeled 3D structures revealed pathological mutations A30P, E46K, H50Q, A53T, A53E associated with early onset Parkinson’s disease caused some increase local propensity α-synuclein. A comparative sequence-based proteins from various evolutionary distant species evaluation their using a set commonly used bioinformatics tools that, irrespective origin, analyzed study were predicted to be disordered proteins, indicating intrinsically nature represents an conserved therefore functionally important feature. detailed functional interactomes utilizing α-synuclein interactome has relatively higher as compared β- γ- relative γ-synuclein interactomes, interactors involved much broader spectrum diversified pathways. Although interacting characterized by functionalities, also common pathways, such synaptic vesicle cycle, serotonergic synapse, retrograde endocannabinoid signaling. Taken together, these observations highlight critical importance neuronal processes.

Язык: Английский

Процитировано

1