
Current Opinion in Neurobiology, Год журнала: 2024, Номер 90, С. 102948 - 102948
Опубликована: Дек. 21, 2024
Язык: Английский
Current Opinion in Neurobiology, Год журнала: 2024, Номер 90, С. 102948 - 102948
Опубликована: Дек. 21, 2024
Язык: Английский
Brain Communications, Год журнала: 2024, Номер 6(4)
Опубликована: Янв. 1, 2024
Patients with epilepsy are characterized by a dysregulation of excitation/inhibition balance (E/I). The assessment E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure brain represents clinically relevant feature. Here, we exploited exponent aperiodic component power spectrum electroencephalography (EEG) signal, as non-invasive cost-effective proxy balance. We recorded resting-state activity high-density EEG from 67 patients temporal lobe 35 controls. extracted fit source-reconstructed tested differences between Spearman's correlation was performed clinical variables (age onset, duration neuropsychology) cortical expression epilepsy-related genes derived Allen Human Brain Atlas. showed significantly larger exponent, corresponding to inhibition-directed balance, in bilateral frontal regions. Lower left entorhinal dorsolateral prefrontal cortices corresponded lower performance short-term verbal memory. Limited epilepsy, detected significant
Язык: Английский
Процитировано
9Frontiers in Neural Circuits, Год журнала: 2025, Номер 18
Опубликована: Янв. 22, 2025
Introduction Neural circuits develop during critical periods (CPs) and exhibit heightened plasticity to adapt the surrounding environment. Accumulating evidence indicates that maturation of inhibitory circuits, such as gamma-aminobutyric acid parvalbumin-positive interneurons, plays a crucial role in CPs contributes generating gamma oscillations. A previous theory CP mechanism suggested inhibition suppresses internally driven spontaneous activity enables synaptic respond external stimuli. However, neural response stimuli neuronal oscillations at population level has not yet been fully clarified. In present study, we aimed investigate responsiveness with respect gamma-band frequencies. Method We calculated inter-trial phase coherence (ITPC), which quantifies event-related modulations across trials, using biologically plausible spiking network generates through interactions between excitatory neurons. Results Our results demonstrated periodic inputs exhibits an inverted U-shape inhibition. Additionally, peak this profile was consistent moderate suppression activity. Discussion This finding suggests population's highly reproducible increased may lead plasticity. computational model can help elucidate underlying mechanisms maximize CPs.
Язык: Английский
Процитировано
1Psychiatry and Clinical Neurosciences, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Aim Autistic traits exhibit neurodiversity with varying behaviors across developmental stages. Brain complexity theory, illustrating the dynamics of neural activity, may elucidate evolution autistic over time. Our study explored patterns brain in individuals from childhood to adulthood. Methods We analyzed functional magnetic resonance imaging data 1087 participants and neurotypical controls aged 6 30 years within ABIDE I (Autism Imaging Data Exchange) set. Sample entropy was calculated measure among 90 regions, utilizing an automated anatomical labeling template for voxel parcellation. Participants were grouped using sliding age windows partial overlaps. assessed average entire regions both groups categories. Cluster analysis conducted generalized association plots identify similar trajectories. Finally, relationship between region examined. Results tend toward higher whole‐brain during adolescence lower adulthood, indicating possible distinct However, these results do not remain after Bonferroni correction. Two clusters identified, each unique changes Correlations complexity, age, also identified. Conclusion The revealed trajectories individuals, providing insight into autism suggesting that age‐related could be a potential neurodevelopmental marker dynamic nature autism.
Язык: Английский
Процитировано
0Current Biology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Developing neural circuits are maximally open to modification during defined critical periods (CPs).1,2,3,4 We previously identified a CP in the Drosophila embryo, from 17 19 h after egg laying (AEL), which activity manipulation (optogenetic and/or pharmacological) permanently alters locomotor network stability.5,6 Analysis of excitatory and inhibitory inputs an motoneuron shows that preferentially enhances excitation.7 This effect is permanent, persisting through third instars (5 days post manipulation). A manifestation this marked increase seizure recovery time (RT) response electric shock. The induced results immediate paralysis, followed by uncoordinated peristalsis until larva recovers sufficiently move away its original position (i.e., endpoint).6 Significantly, exposure blue light (BL) same embryonic temporal window similarly able lead increased RT, requires presence CRYPTOCHROME (CRY).8 Here, we identify series BL-sensitive CPs, occurring at ∼24-h intervals, embryogenesis larval development. Exposure BL these CPs increases taken for wandering larvae recover electroshock-induced activity. absent when CRY or principal clock-signaling neuropeptide-pigment-dispersing factor (PDF)-is absent. Thus, uncover novel role circadian clock stages
Язык: Английский
Процитировано
0iScience, Год журнала: 2024, Номер 27(11), С. 111083 - 111083
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
1Journal of Neuroscience, Год журнала: 2024, Номер 44(48), С. e1367242024 - e1367242024
Опубликована: Ноя. 27, 2024
The nervous system contains complex circuits comprising thousands of cell types and trillions connections. Here, we discuss how the field “developmental systems neuroscience” combines molecular genetic perspectives developmental neuroscience with (typically adult-focused) functional perspective neuroscience. This combination approaches is critical to understanding a handful cells eventually produce wide range behaviors necessary for survival. Functional circuit development typically lags behind neural connectivity, leading intermediate stages activity that are either not seen in adults or, if present, considered pathophysiological. Developmental examines these activity, mapping out phases inflection points function understand behavior emerge across development. Beyond typical development, this approach provides invaluable insight into pathophysiology neurodevelopmental disorders by identifying when diverges between health disease. We argue will identify important periods reveal novel therapeutic windows treatment, set stage answer fundamental questions about brain
Язык: Английский
Процитировано
0Current Opinion in Neurobiology, Год журнала: 2024, Номер 90, С. 102948 - 102948
Опубликована: Дек. 21, 2024
Язык: Английский
Процитировано
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