A cross-species analysis of neuroanatomical covariance sex difference in humans and mice DOI Creative Commons
Linh Pham, Elisa Guma, Jacob Ellegood

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

ABSTRACT Structural covariance in brain anatomy is thought to reflect inter-regional sharing of developmental influences - although this hypothesis has proved hard causally test. Here, we use neuroimaging humans and mice study sex-differences anatomical asking if regions that have developed shared sex differences volume across species also show difference covariance. This design illuminates both the biology theoretical models for – benefitting from tests inter-species convergence. We find volumetric structural stronger adult females compared males wild-type healthy human subjects: 98% all comparisons with statistically significant are female-biased, while 76% such female-biased (q < 0.05). In species, a region’s sex-biases weak inverse relationships each other: volumetrically male-biased contain more covariations, covariations (mice: r = −0.185, p 0.002; humans: −0.189, 0.001). Our results identify conserved tendency neuroanatomical than males, evident which suggests could be an evolutionarily feature partially related alterations through sex. SIGNIFICANCE STATEMENT potent readout coordinated development, but probe experimentally. Here as naturally occurring test theories adopting cross-species approach validation translational benefit. Brain MRI reveals two features mice: (i) tighter coordination development evidenced by covariance; (ii) involve smaller suggesting unknown counterbalancing between these distinct modes sex-biased organization. These findings advance understanding framework facilitating future research on topics.

Язык: Английский

Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation DOI Creative Commons
Jonas Yeung, Taylor DeYoung, Shoshana Spring

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(36)

Опубликована: Авг. 29, 2024

The course of normal development and response to pathology are strongly influenced by biological sex. For instance, female childhood cancer survivors who have undergone cranial radiation therapy (CRT) tend display more pronounced cognitive deficits than their male counterparts. Sex effects can be the result sex chromosome complement (XX vs. XY) and/or gonadal hormone influence. contributions each separated using four-core genotype mouse model (FCG), where decoupled. While studies FCG mice evaluated brain differences in adulthood, it is still unclear how emerge through both healthy pathological contexts. Our study utilizes longitudinal MRI with investigate after CRT wildtype immune-modified Ccl2 -knockout mice. findings normally developing reveal a relatively prominent effect prepubertally, compared which largely later. Spatially, influences were independent one another. After mice, chromosomes hormones similarly improved outcomes but did so separately combination. highlight crucial role early identify roles for CRT-induced inflammation, highlighting pathology.

Язык: Английский

Процитировано

4
Strategies for studying sex differences in brain aging DOI Creative Commons
Victor A. Ansere, Seungsoo Kim, Francesca Marino

и другие.

Trends in Genetics, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The microbiota shapes the development of the mouse hypothalamic paraventricular nucleus DOI

Yvonne C Milligan,

Nicole V. Peters,

G. Alexander West

и другие.

Hormones and Behavior, Год журнала: 2025, Номер 172, С. 105742 - 105742

Опубликована: Апрель 21, 2025

Язык: Английский

Процитировано

0
Considering the interconnected nature of social identities in neuroimaging research DOI
Elvisha Dhamala, Jocelyn A. Ricard, Lucina Q. Uddin

и другие.

Nature Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Язык: Английский

Процитировано

2
Chronic Morphine Leaves a Durable Fingerprint on Whole-Brain Functional Connectivity DOI
Marion Sourty,

Cédric Champagnol-Di Liberti,

Md Taufiq Nasseef

и другие.

Biological Psychiatry, Год журнала: 2023, Номер 96(9), С. 708 - 716

Опубликована: Дек. 15, 2023

Язык: Английский

Процитировано

3
The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber DOI Creative Commons
Paul A. S. Sheppard,

Charlotte A. Oomen,

Timothy J. Bussey

и другие.

eNeuro, Год журнала: 2024, Номер 11(6), С. ENEURO.0120 - 24.2024

Опубликована: Июнь 1, 2024

The retrosplenial cortex (RSC) is a hub of diverse afferent and efferent projections thought to be involved in associative learning. RSC shows early pathology mild cognitive impairment Alzheimer's disease (AD), which impairs To understand develop therapies for diseases such as AD, animal models are essential. Given the importance human object-location learning success paradigms studies clinic, it would considerable value establish translational model rodent. For this reason, we sought test role male rats using paired-associates (PAL) touchscreen task. First, increased cFos immunoreactivity was observed granular following PAL training when compared with extended pretraining controls. Following this, lesions acquisition were used explore necessity memory two tasks involving only one modality: trial-unique nonmatching-to-location spatial working pairwise visual discrimination/reversal. impaired both learned new associations but did not affect performance either or single-modality tasks. These findings provide evidence that necessary less so individual modalities therein.

Язык: Английский

Процитировано

0
A cross-species analysis of neuroanatomical covariance sex difference in humans and mice DOI Creative Commons
Linh Pham, Elisa Guma, Jacob Ellegood

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

ABSTRACT Structural covariance in brain anatomy is thought to reflect inter-regional sharing of developmental influences - although this hypothesis has proved hard causally test. Here, we use neuroimaging humans and mice study sex-differences anatomical asking if regions that have developed shared sex differences volume across species also show difference covariance. This design illuminates both the biology theoretical models for – benefitting from tests inter-species convergence. We find volumetric structural stronger adult females compared males wild-type healthy human subjects: 98% all comparisons with statistically significant are female-biased, while 76% such female-biased (q < 0.05). In species, a region’s sex-biases weak inverse relationships each other: volumetrically male-biased contain more covariations, covariations (mice: r = −0.185, p 0.002; humans: −0.189, 0.001). Our results identify conserved tendency neuroanatomical than males, evident which suggests could be an evolutionarily feature partially related alterations through sex. SIGNIFICANCE STATEMENT potent readout coordinated development, but probe experimentally. Here as naturally occurring test theories adopting cross-species approach validation translational benefit. Brain MRI reveals two features mice: (i) tighter coordination development evidenced by covariance; (ii) involve smaller suggesting unknown counterbalancing between these distinct modes sex-biased organization. These findings advance understanding framework facilitating future research on topics.

Язык: Английский

Процитировано

0