Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior
PLoS Pathogens,
Год журнала:
2025,
Номер
21(1), С. e1012932 - e1012932
Опубликована: Янв. 31, 2025
Baculoviruses
can
induce
climbing
behavior
in
caterpillar
hosts,
which
provides
an
excellent
model
for
studying
parasite
manipulation
of
host
behavior.
Herein,
we
found
that
Helicoverpa
armigera
single
nucleopolyhedrovirus
(HearNPV)
promoted
lipid
metabolism
infected
H.
larvae,
and
changes
affect
Therefore,
understanding
the
molecular
mechanisms
between
is
particularly
important.
In
this
study,
adipokinetic
hormone
1
(HaAKH1),
2
(HaAKH2)
their
receptor
HaAKHR
were
essential
promoting
response
to
HearNPV
infection.
Both
docking
result
Ca2+
imaging
showed
both
HaAKH1
HaAKH2
could
interact
with
HaAKHR.
Knockdown
HaAKH1,
resulted
not
only
accumulation
triacylglycerol
(TAG),
but
also
reduction
replication
crawling
ability
resulting
a
decrease
final
death
height
larvae.
We
further
validated
conclusion
by
injecting
active
peptides
addition,
investigated
downstream
HaAKH
signaling
hormone-sensitive
lipase
(HaHSL)
changed
HaHSL
played
same
role
as
signaling.
These
findings
revealed
mechanism
parasites
manipulated
metabolism,
more
significantly,
explored
relationship
behavioral
hosts
parasites,
broadening
our
phenomenon
manipulating
changes.
Язык: Английский
Neuropeptide Ecdysis‐Triggering Hormone and Its Receptor Mediate the Fecundity Improvement of ‘Candidatus Liberibacter Asiaticus’‐Infected Diaphorina citri Females and CLas Proliferation
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
The
severe
Asiatic
form
of
huanglongbing
(HLB),
caused
by
"Candidatus
Liberibacter
asiaticus"
(CLas),
threatens
global
citrus
production
via
the
psyllid,
Diaphorina
citri.
Culturing
challenges
CLas
necessitate
reducing
D.
citri
populations
for
disease
management.
boosts
fecundity
CLas-positive
(CLas+)
and
fosters
its
own
proliferation
modulating
insect
host's
juvenile
hormone
(JH),
but
intricate
endocrine
regulatory
mechanisms
remain
elusive.
Here,
it
is
reported
that
ecdysis-triggering
(DcETH)
receptor
DcETHR
play
pivotal
roles
in
reciprocal
benefits
between
within
ovaries,
influencing
energy
metabolism
reproductive
development
host
insects;
miR-210,
negatively
regulates
expression,
contributing
to
this
symbiotic
interaction.
infection
reduces
20-hydroxyecdysone
(20E)
levels
stimulates
DcETH
release,
elevating
JH
DcETHR,
enhancing
proliferation.
Furthermore,
circulating
suppress
20E
CLas+
ovaries.
Collectively,
orchestrated
functional
interplay
involving
20E,
ETH,
increases
promotes
These
insights
not
only
broaden
knowledge
how
plant
pathogens
manipulate
behavior
hosts
also
offer
novel
targets
strategies
combatting
HLB
Язык: Английский
Balancing metabolism and reproduction
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Апрель 11, 2024
The
bacterium
responsible
for
a
disease
that
infects
citrus
plants
across
Asia
facilitates
its
own
proliferation
by
increasing
the
fecundity
of
host
insect.
Язык: Английский
Transcription Factor CcFoxO Mediated the Transition from Summer Form to Winter Form in Cacopsylla chinensis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8545 - 8545
Опубликована: Авг. 5, 2024
Amid
global
climate
change
featuring
erratic
temperature
fluctuations,
insects
adapt
via
seasonal
polyphenism,
essential
for
population
sustainability
and
reproductive
success.
Cacopsylla
chinensis,
influenced
by
environment
variations,
displays
a
distinct
summer
form
winter
distinguished
significant
morphological
variations.
Previous
studies
have
highlighted
the
role
of
receptor
CcTPRM
in
orchestrating
transition
response
to
10
°C
temperature.
Nevertheless,
contribution
transcription
factor
FoxO
this
process
has
remained
ambiguous.
Here,
we
aimed
explore
correlation
between
C.
chinensis
(CcFoxO)
cold
stress
responses,
while
identifying
potential
energetic
substances
monitoring
physiological
shifts
during
from
under
using
RNAi.
Initially,
CcFoxO
emerges
as
responsive
low
temperatures
(10
°C)
is
regulated
CcTRPM.
Subsequent
investigations
reveal
that
facilitates
accumulation
triglycerides
glycogen,
thereby
influencing
affecting
cuticle
pigment
content,
chitin
levels,
thickness.
Thus,
knockdown
led
high
mortality
failed
transition.
Overall,
our
findings
demonstrate
governs
polyphenism
regulating
energy
storage.
These
insights
not
only
enhance
comprehension
functionality
but
also
offer
avenues
environmentally
friendly
management
strategies
chinensis.
Язык: Английский
ZnO quantum dots reduce acquisition of huanglongbing pathogen by Diaphorina citri
Pest Management Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
Abstract
BACKGROUND
Diaphorina
citri
Kuwayama
is
the
main
vector
of
Huanglongbing
(HLB)
pathogen
Candidatus
Liberibacter
asiaticus
(
C
Las).
Therefore,
reducing
Las
acquisition
by
D.
crucial
for
controlling
spread
HLB.
RESULTS
This
study
aimed
to
investigate
effect
ZnO
quantum
dots
(ZnO
QDs)
on
.
The
results
showed
that
QDs
were
absorbed
citrus
plants
and
,
inducing
reactive
oxygen
species
generation
in
intestine
causing
intestinal
cell
apoptosis.
uptake
rate
was
reduced
75%
22.3%
after
treatment
with
2
5
mg
∙
mL
−1
QDs,
respectively,
compared
100%
control
group.
Transcription
analysis
significant
changes
expression
genes
related
apoptosis,
oxidative
stress,
DNA
replication
repair.
CONCLUSION
suggested
could
efficiently
reduce
providing
a
safe
reliable
tool
HLB
prevention
control.
©
2024
Society
Chemical
Industry.
Язык: Английский