BioEssays, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
ABSTRACT The TGF‐β/BMP signaling superfamily plays critical roles in regulating a wide range of physiological and pathological processes. A recent study on Tgfbr1 function during mouse embryonic development found that, the absence this gene, primordium external genitalia changes its fate, forming an additional set hindlimbs resulting so‐called “six‐legged” mice. Analysis these embryos demonstrated that induces global remodeling chromatin accessibility, establishing distinct regulatory elements other morphogenetic factors use to drive either hindlimb or genital development. While structure have been previously associated with TGF‐β signaling, alterations seen six‐legged differ significantly from described mechanisms. In review, I discuss distinctions underscore importance studying biological processes within their natural tissue context, where essential interactions are preserved.
Язык: Английский