The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts DOI Creative Commons

X. Ding,

Nathan W. Vogler, Mélanie Tobin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

ABSTRACT Detecting statistical regularities in sound and responding to violations of these patterns, termed novelty detection, is a core function the auditory system. Human studies have shown that responses are enhanced regular compared random contexts, but underlying circuit mechanisms remain unclear. Here, we examined how inhibitory neurons contribute context-dependent mouse cortex. Using two-photon calcium imaging cortex awake head-fixed male female mice, recorded neuronal activity during presentation spectro-temporally rich ripple sounds, with novel ripples embedded either or sequences. AC exhibited sounds contexts ones. To identify mechanisms, selectively inactivated parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP) using optogenetics imaging. Inactivation PV SST broadly increased both contexts. In contrast, VIP inactivation reduced stimuli context, abolishing enhancement. At population level, inactivating all three subtypes detectability stimulus, inactivation, shift was stronger for than context. These findings reveal distinct role modulating prediction error signals based on temporal structure, suggesting circuits critical context-sensitive processing.

Язык: Английский

The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts DOI Creative Commons

X. Ding,

Nathan W. Vogler, Mélanie Tobin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

ABSTRACT Detecting statistical regularities in sound and responding to violations of these patterns, termed novelty detection, is a core function the auditory system. Human studies have shown that responses are enhanced regular compared random contexts, but underlying circuit mechanisms remain unclear. Here, we examined how inhibitory neurons contribute context-dependent mouse cortex. Using two-photon calcium imaging cortex awake head-fixed male female mice, recorded neuronal activity during presentation spectro-temporally rich ripple sounds, with novel ripples embedded either or sequences. AC exhibited sounds contexts ones. To identify mechanisms, selectively inactivated parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP) using optogenetics imaging. Inactivation PV SST broadly increased both contexts. In contrast, VIP inactivation reduced stimuli context, abolishing enhancement. At population level, inactivating all three subtypes detectability stimulus, inactivation, shift was stronger for than context. These findings reveal distinct role modulating prediction error signals based on temporal structure, suggesting circuits critical context-sensitive processing.

Язык: Английский

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