Journal of Molecular Recognition, Год журнала: 2024, Номер unknown
Опубликована: Окт. 12, 2024
ABSTRACT The Sec61 translocon mediates the translocation of numerous, newly synthesized precursor proteins into lumen endoplasmic reticulum or their integration its membrane. Recently, structural biology revealed conformations idle substrate‐engaged Sec61, and likewise interactions with accessory membrane Sec62, Sec63, TRAP, respectively. Several natural synthetic small molecules have been shown to block Sec61‐mediated protein translocation. Since this is a key step in biogenesis, broad inhibition generally cytotoxic, which may be problematic for putative drug target. Interestingly, several compounds exhibit client‐selective modes action, such that only certain was affected. Here, we discuss recent advances biology, molecular modelling, screening aim use as feasible
Язык: Английский