Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling DOI Creative Commons
Benjamin Le Gac, Marine Tournissac,

Esther Belzic

и другие.

eLife, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Neurovascular coupling, linking neuronal activity to cerebral blood flow, is essential for brain function and underpins functional imaging. Whereas mechanisms involved in vasodilation are well-documented, those controlling vasoconstriction remain overlooked. This study unravels the by which pyramidal cells elicit arteriole vasoconstriction. Using patch-clamp recording, vascular Ca2+ imaging mouse cortical slices, we show that strong optogenetic activation of layer II/III induces vasoconstriction, correlating with firing frequency somatic increase. Ex vivo pharmacological investigations indicate this predominantly recruits prostaglandin E2 through cyclooxygenase-2 pathway, EP1 EP3 receptors. We also present evidence specific interneurons releasing neuropeptide Y, astrocytes, 20-hydroxyeicosatetraenoic acid, contribute process. By revealing lead our findings shed light on complex regulation neurovascular coupling.

Язык: Английский

Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling DOI Open Access
Benjamin Le Gac, Marine Tournissac,

Esther Belzic

и другие.

Опубликована: Март 6, 2025

Neurovascular coupling, linking neuronal activity to cerebral blood flow, is essential for brain function and underpins functional imaging. Whereas mechanisms involved in vasodilation are well-documented, those controlling vasoconstriction remain overlooked. This study unravels the by which pyramidal cells elicit arteriole vasoconstriction. Using patch-clamp recording, vascular Ca 2+ imaging mouse cortical slices, we show that strong optogenetic activation of layer II/III induces vasoconstriction, correlating with firing frequency somatic increase. Ex vivo pharmacological investigations indicate this predominantly recruits prostaglandin E2 through cyclooxygenase-2 pathway, EP1 EP3 receptors. We also present evidence specific interneurons releasing neuropeptide Y, astrocytes, 20-hydroxyeicosatetraenoic acid, contribute process. By revealing lead our findings shed light on complex regulation neurovascular coupling.

Язык: Английский

Процитировано

0
Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin DOI Creative Commons

Raphaële Mongrédien,

Augusto Anésio,

Gustavo J. D. Fernandes

и другие.

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Electroacupuncture Serum Alleviates Ogd/R-Induced Astrocyte Damage by Regulating the AQP4 Via m6A Methylation of lncRNA MALAT1 DOI
H. Zhang, Xiaomeng Xu, Xinying Li

и другие.

Neurochemical Research, Год журнала: 2025, Номер 50(2)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Clinical reflections of the glymphatic system and neurodegenerative diseases DOI
Zümrüt Doğan, Seda Cetın

Journal of Medical Topics and Updates, Год журнала: 2025, Номер 4(1), С. 16 - 22

Опубликована: Апрель 30, 2025

Objective: The brain is one of the main elements central nervous system and protected within bone structure formed by skull bones. endocrine play a fundamental role in maintaining homeostasis. brain; How are wastes that occur as result these biochemical events eliminated when it has such basic important tasks? Until 2012, was thought there no lymphatic brain. Our aim with this literature review to make easier find answers questions. Materials Methods: For research, existing systematically reviewed terms glymphatic system. Results: brain’s waste clearance mechanism. Many anatomical structures involved Astrocytes aquaporin-4 channels were most notable these. Conclusions: clearing mechanism many function mechanisms. Although been subject current research human animal experiments recent years, still an area preserves its mystery. remains mysterious. Disruption closely associated neurodegenerative diseases. We believe system, which plays vital health, should be more scientific clarify functioning

Язык: Английский

Процитировано

0
Reactive Astrocytes in Glioma: Emerging Opportunities and Challenges DOI Open Access
J. Wu, Ran Li, Junwen Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2907 - 2907

Опубликована: Март 23, 2025

Gliomas are the most prevalent malignant tumors in adult central nervous system (CNS). Glioblastoma (GBM) accounts for approximately 60-70% of primary gliomas. It is a great challenge to human health because its high degree malignancy, rapid progression, short survival time, and susceptibility recurrence. Owing specificity CNS, glioma microenvironment often contains numerous glial cells. Astrocytes widely distributed brain form reactive astrocyte proliferation regions around tissue. In addition, astrocytes activated under pathological conditions regulate tumor microenvironmental cells through cell-to-cell contact or secretion active substances. Therefore, have attracted attention as important components microenvironment. Here, we focus on mechanisms activation conditions, their contribution genesis potential value targets clinical intervention

Язык: Английский

Процитировано

0
Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling DOI Creative Commons
Benjamin Le Gac, Marine Tournissac,

Esther Belzic

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Апрель 23, 2025

Neurovascular coupling, linking neuronal activity to cerebral blood flow, is essential for brain function and underpins functional imaging. Whereas mechanisms involved in vasodilation are well-documented, those controlling vasoconstriction remain overlooked. This study unravels the by which pyramidal cells elicit arteriole vasoconstriction. Using patch-clamp recording, vascular Ca 2+ imaging mouse cortical slices, we show that strong optogenetic activation of layer II/III induces vasoconstriction, correlating with firing frequency somatic increase. Ex vivo pharmacological investigations indicate this predominantly recruits prostaglandin E2 through cyclooxygenase-2 pathway, EP1 EP3 receptors. We also present evidence specific interneurons releasing neuropeptide Y, astrocytes, 20-hydroxyeicosatetraenoic acid, contribute process. By revealing lead our findings shed light on complex regulation neurovascular coupling.

Язык: Английский

Процитировано

0
Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling DOI Creative Commons
Benjamin Le Gac, Marine Tournissac,

Esther Belzic

и другие.

eLife, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Neurovascular coupling, linking neuronal activity to cerebral blood flow, is essential for brain function and underpins functional imaging. Whereas mechanisms involved in vasodilation are well-documented, those controlling vasoconstriction remain overlooked. This study unravels the by which pyramidal cells elicit arteriole vasoconstriction. Using patch-clamp recording, vascular Ca2+ imaging mouse cortical slices, we show that strong optogenetic activation of layer II/III induces vasoconstriction, correlating with firing frequency somatic increase. Ex vivo pharmacological investigations indicate this predominantly recruits prostaglandin E2 through cyclooxygenase-2 pathway, EP1 EP3 receptors. We also present evidence specific interneurons releasing neuropeptide Y, astrocytes, 20-hydroxyeicosatetraenoic acid, contribute process. By revealing lead our findings shed light on complex regulation neurovascular coupling.

Язык: Английский

Процитировано

0