An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila DOI Creative Commons
MinHyuk Lee, Seong-min Kim,

Taeim Park

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(3)

Опубликована: Янв. 17, 2025

In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, molecular mechanisms that mediate and modulate coupling’s effects remain poorly understood. Here, we show hyperpolarization-activated cyclic nucleotide–gated (HCN) channel lateralizes potentially mutual inhibition between Drosophila gustatory receptor (GRNs). While sweet-sensing GRNs (sGRNs) engage in suppression of bitter-sensing (bGRNs), HCN expression sGRNs enables them to resist from bGRNs. This one-sided confers sweetness dominance, facilitating ingestion bitter-laced sweets. The role fly this process can be replaced by human HCN2. Furthermore, unlike mechanism olfaction, is independent sensillum potential changes, suggesting compartmentalized arrangement neighboring dispensable for inhibition. These findings indicate a gating coding ensure intake essential nutrient despite bitter contaminants present feeding niche , propose studies gustation could reveal principles conserved across diverse animals.

Язык: Английский

An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila DOI Creative Commons
MinHyuk Lee, Seong-min Kim,

Taeim Park

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(3)

Опубликована: Янв. 17, 2025

In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, molecular mechanisms that mediate and modulate coupling’s effects remain poorly understood. Here, we show hyperpolarization-activated cyclic nucleotide–gated (HCN) channel lateralizes potentially mutual inhibition between Drosophila gustatory receptor (GRNs). While sweet-sensing GRNs (sGRNs) engage in suppression of bitter-sensing (bGRNs), HCN expression sGRNs enables them to resist from bGRNs. This one-sided confers sweetness dominance, facilitating ingestion bitter-laced sweets. The role fly this process can be replaced by human HCN2. Furthermore, unlike mechanism olfaction, is independent sensillum potential changes, suggesting compartmentalized arrangement neighboring dispensable for inhibition. These findings indicate a gating coding ensure intake essential nutrient despite bitter contaminants present feeding niche , propose studies gustation could reveal principles conserved across diverse animals.

Язык: Английский

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