Attentional modulation of secondary somatosensory and visual thalamus of mice
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Июнь 24, 2024
Each
sensory
modality
has
its
own
primary
and
secondary
thalamic
nuclei.
While
the
nuclei
are
well
understood
to
relay
information
from
periphery
cortex,
role
of
is
elusive.
We
trained
head-fixed
mice
attend
one
while
ignoring
a
second
modality,
namely
touch
ignore
vision,
or
vice
versa.
Arrays
were
used
record
simultaneously
somatosensory
thalamus
(POm)
visual
(LP).
In
respond
tactile
stimuli
stimuli,
POm
was
robustly
activated
by
largely
unresponsive
stimuli.
A
different
pattern
observed
when
touch,
with
now
more
during
trials.
This
activity
not
explained
differences
in
movements
(i.e.
whisking,
licking,
pupil
dilation)
resulting
two
tasks.
Post
hoc
histological
reconstruction
array
tracks
through
revealed
that
subregions
varied
their
degree
plasticity.
LP
exhibited
similar
phenomena.
conclude
behavioral
training
reshapes
Secondary
same
behaviorally
relevant,
reward-predicting
regardless
stimulus
modality.
Язык: Английский
Learning enhances behaviorally relevant representations in apical dendrites
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Июнь 13, 2024
Learning
alters
cortical
representations
and
improves
perception.
Apical
tuft
dendrites
in
layer
1,
which
are
unique
their
connectivity
biophysical
properties,
may
be
a
key
site
of
learning-induced
plasticity.
We
used
both
two-photon
SCAPE
microscopy
to
longitudinally
track
tuft-wide
calcium
spikes
apical
5
pyramidal
neurons
barrel
cortex
as
mice
learned
tactile
behavior.
Mice
were
trained
discriminate
two
orthogonal
directions
whisker
stimulation.
Reinforcement
learning,
but
not
repeated
stimulus
exposure,
enhanced
selectivity
for
equally,
even
though
only
one
was
associated
with
reward.
Selective
tufts
emerged
from
initially
unresponsive
or
low-selectivity
populations.
Animal
movement
choice
did
account
changes
selectivity.
Enhanced
persisted
after
rewards
removed
animals
ceased
performing
the
task.
conclude
that
learning
produces
long-lasting
realignment
dendrite
responses
behaviorally
relevant
dimensions
Язык: Английский
Active and passive touch are differentially represented in the mouse somatosensory thalamus
PLoS Biology,
Год журнала:
2025,
Номер
23(4), С. e3003108 - e3003108
Опубликована: Апрель 8, 2025
Active
and
passive
sensing
strategies
are
integral
to
an
animal’s
behavioral
repertoire.
Nevertheless,
there
is
a
lack
of
information
regarding
the
neuronal
circuitry
that
underpins
these
strategies,
particularly
at
thalamus
level.
We
evaluated
how
active
versus
whisker
deflections
represented
in
single
neurons
ventral
posteromedial
(VPM)
posterior
medial
(POm)
awake
mice.
These
first-
higher-order
thalamic
nuclei
system,
respectively.
VPM
robustly
responded
both
deflections,
while
POm
showed
preference
for
poorly
touches.
This
response
disparity
could
not
be
explained
by
stimulus
kinematics
only
part
voluntary
whisking
state.
In
contrast,
cortical
activity
significantly
influenced
POm’s
responses
touch.
Inhibition
barrel
cortex
strongly
attenuated
simultaneously
increased
phase
coding.
suggests
receives
touch
from
which
adapts
gated
rare
events.
Together,
findings
suggest
two
relay
streams,
where
relays
deflection,
sensitivity
requires
top-down
involvement
signal
salient
events
such
as
unexpected
originating
environment.
Язык: Английский
Learning enhances behaviorally relevant representations in apical dendrites
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2021,
Номер
unknown
Опубликована: Ноя. 11, 2021
SUMMARY
Learning
alters
cortical
representations
and
improves
perception.
Apical
tuft
dendrites
in
Layer
1,
which
are
unique
their
connectivity
biophysical
properties,
may
be
a
key
site
of
learning-induced
plasticity.
We
used
both
two-photon
SCAPE
microscopy
to
longitudinally
track
tuft-wide
calcium
spikes
apical
5
pyramidal
neurons
barrel
cortex
as
mice
learned
tactile
behavior.
Mice
were
trained
discriminate
two
orthogonal
directions
whisker
stimulation.
Reinforcement
learning,
but
not
repeated
stimulus
exposure,
enhanced
selectivity
for
equally,
even
though
only
one
was
associated
with
reward.
Selective
tufts
emerged
from
initially
unresponsive
or
low-selectivity
populations.
Animal
movement
choice
did
account
changes
selectivity.
Enhanced
persisted
after
rewards
removed
animals
ceased
performing
the
task.
conclude
that
learning
produces
long-lasting
realignment
dendrite
responses
behaviorally
relevant
dimensions
Язык: Английский
Learning enhances behaviorally relevant representations in apical dendrites
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Дек. 27, 2024
Learning
alters
cortical
representations
and
improves
perception.
Apical
tuft
dendrites
in
layer
1,
which
are
unique
their
connectivity
biophysical
properties,
may
be
a
key
site
of
learning-induced
plasticity.
We
used
both
two-photon
SCAPE
microscopy
to
longitudinally
track
tuft-wide
calcium
spikes
apical
5
pyramidal
neurons
barrel
cortex
as
mice
learned
tactile
behavior.
Mice
were
trained
discriminate
two
orthogonal
directions
whisker
stimulation.
Reinforcement
learning,
but
not
repeated
stimulus
exposure,
enhanced
selectivity
for
equally,
even
though
only
one
was
associated
with
reward.
Selective
tufts
emerged
from
initially
unresponsive
or
low-selectivity
populations.
Animal
movement
choice
did
account
changes
selectivity.
Enhanced
persisted
after
rewards
removed
animals
ceased
performing
the
task.
conclude
that
learning
produces
long-lasting
realignment
dendrite
responses
behaviorally
relevant
dimensions
Язык: Английский
Reward history guides attentional selection in whisker somatosensory (S1) cortex
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 21, 2024
Prior
reward
is
a
potent
cue
for
attentional
capture,
but
the
underlying
neurobiology
largely
unknown.
In
novel
whisker
touch
detection
task,
we
show
that
mice
flexibly
shift
attention
between
specific
whiskers
on
trial-by-trial
timescale,
guided
by
recent
history
of
stimulus-reward
association.
Two-photon
calcium
imaging
and
spike
recordings
revealed
robust
neurobiological
correlate
in
somatosensory
cortex
(S1),
boosting
sensory
responses
to
attended
L2/3
L5,
not
L4.
Attentional
pyramidal
cells
was
topographically
precise
whisker-specific,
shifted
receptive
fields
toward
whisker.
VIP
interneurons
were
broadly
activated
stimuli,
motion,
arousal
did
carry
whisker-specific
signal,
thus
mediate
spatially
focused
tactile
attention.
Together,
these
findings
establish
new
model
focal
mouse
system,
showing
stimuli
rewards
past
can
dynamically
engage
local
modulation
cortical
maps
guide
flexible
shifts
ongoing
behavior.
Язык: Английский