Reward history guides attentional selection in whisker somatosensory (S1) cortex DOI Creative Commons
Deepa L. Ramamurthy, Lucia Rodriguez,

Chaochao Cen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Prior reward is a potent cue for attentional capture, but the underlying neurobiology largely unknown. In novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on trial-by-trial timescale, guided by recent history of stimulus-reward association. Two-photon calcium imaging and spike recordings revealed robust neurobiological correlate in somatosensory cortex (S1), boosting sensory responses to attended L2/3 L5, not L4. Attentional pyramidal cells was topographically precise whisker-specific, shifted receptive fields toward whisker. VIP interneurons were broadly activated stimuli, motion, arousal did carry whisker-specific signal, thus mediate spatially focused tactile attention. Together, these findings establish new model focal mouse system, showing stimuli rewards past can dynamically engage local modulation cortical maps guide flexible shifts ongoing behavior.

Язык: Английский

Attentional modulation of secondary somatosensory and visual thalamus of mice DOI Creative Commons
Gordon H Petty, Randy M. Bruno

eLife, Год журнала: 2024, Номер 13

Опубликована: Июнь 24, 2024

Each sensory modality has its own primary and secondary thalamic nuclei. While the nuclei are well understood to relay information from periphery cortex, role of is elusive. We trained head-fixed mice attend one while ignoring a second modality, namely touch ignore vision, or vice versa. Arrays were used record simultaneously somatosensory thalamus (POm) visual (LP). In respond tactile stimuli stimuli, POm was robustly activated by largely unresponsive stimuli. A different pattern observed when touch, with now more during trials. This activity not explained differences in movements (i.e. whisking, licking, pupil dilation) resulting two tasks. Post hoc histological reconstruction array tracks through revealed that subregions varied their degree plasticity. LP exhibited similar phenomena. conclude behavioral training reshapes Secondary same behaviorally relevant, reward-predicting regardless stimulus modality.

Язык: Английский

Процитировано

6
Learning enhances behaviorally relevant representations in apical dendrites DOI Creative Commons
Sam E. Benezra, Kripa Patel, Citlali Pérez Campos

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Июнь 13, 2024

Learning alters cortical representations and improves perception. Apical tuft dendrites in layer 1, which are unique their connectivity biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon SCAPE microscopy to longitudinally track tuft-wide calcium spikes apical 5 pyramidal neurons barrel cortex as mice learned tactile behavior. Mice were trained discriminate two orthogonal directions whisker stimulation. Reinforcement learning, but not repeated stimulus exposure, enhanced selectivity for equally, even though only one was associated with reward. Selective tufts emerged from initially unresponsive or low-selectivity populations. Animal movement choice did account changes selectivity. Enhanced persisted after rewards removed animals ceased performing the task. conclude that learning produces long-lasting realignment dendrite responses behaviorally relevant dimensions

Язык: Английский

Процитировано

3
Active and passive touch are differentially represented in the mouse somatosensory thalamus DOI Creative Commons
Anton Sumser, Emilio Ulises Isaías-Camacho, Rebecca A. Mease

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3003108 - e3003108

Опубликована: Апрель 8, 2025

Active and passive sensing strategies are integral to an animal’s behavioral repertoire. Nevertheless, there is a lack of information regarding the neuronal circuitry that underpins these strategies, particularly at thalamus level. We evaluated how active versus whisker deflections represented in single neurons ventral posteromedial (VPM) posterior medial (POm) awake mice. These first- higher-order thalamic nuclei system, respectively. VPM robustly responded both deflections, while POm showed preference for poorly touches. This response disparity could not be explained by stimulus kinematics only part voluntary whisking state. In contrast, cortical activity significantly influenced POm’s responses touch. Inhibition barrel cortex strongly attenuated simultaneously increased phase coding. suggests receives touch from which adapts gated rare events. Together, findings suggest two relay streams, where relays deflection, sensitivity requires top-down involvement signal salient events such as unexpected originating environment.

Язык: Английский

Процитировано

0
Learning enhances behaviorally relevant representations in apical dendrites DOI Creative Commons
Sam E. Benezra, Kripa Patel, Citlali Pérez Campos

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Ноя. 11, 2021

SUMMARY Learning alters cortical representations and improves perception. Apical tuft dendrites in Layer 1, which are unique their connectivity biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon SCAPE microscopy to longitudinally track tuft-wide calcium spikes apical 5 pyramidal neurons barrel cortex as mice learned tactile behavior. Mice were trained discriminate two orthogonal directions whisker stimulation. Reinforcement learning, but not repeated stimulus exposure, enhanced selectivity for equally, even though only one was associated with reward. Selective tufts emerged from initially unresponsive or low-selectivity populations. Animal movement choice did account changes selectivity. Enhanced persisted after rewards removed animals ceased performing the task. conclude that learning produces long-lasting realignment dendrite responses behaviorally relevant dimensions

Язык: Английский

Процитировано

6
Learning enhances behaviorally relevant representations in apical dendrites DOI Creative Commons
Sam E. Benezra, Kripa Patel, Citlali Pérez Campos

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Дек. 27, 2024

Learning alters cortical representations and improves perception. Apical tuft dendrites in layer 1, which are unique their connectivity biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon SCAPE microscopy to longitudinally track tuft-wide calcium spikes apical 5 pyramidal neurons barrel cortex as mice learned tactile behavior. Mice were trained discriminate two orthogonal directions whisker stimulation. Reinforcement learning, but not repeated stimulus exposure, enhanced selectivity for equally, even though only one was associated with reward. Selective tufts emerged from initially unresponsive or low-selectivity populations. Animal movement choice did account changes selectivity. Enhanced persisted after rewards removed animals ceased performing the task. conclude that learning produces long-lasting realignment dendrite responses behaviorally relevant dimensions

Язык: Английский

Процитировано

0
Reward history guides attentional selection in whisker somatosensory (S1) cortex DOI Creative Commons
Deepa L. Ramamurthy, Lucia Rodriguez,

Chaochao Cen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Prior reward is a potent cue for attentional capture, but the underlying neurobiology largely unknown. In novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on trial-by-trial timescale, guided by recent history of stimulus-reward association. Two-photon calcium imaging and spike recordings revealed robust neurobiological correlate in somatosensory cortex (S1), boosting sensory responses to attended L2/3 L5, not L4. Attentional pyramidal cells was topographically precise whisker-specific, shifted receptive fields toward whisker. VIP interneurons were broadly activated stimuli, motion, arousal did carry whisker-specific signal, thus mediate spatially focused tactile attention. Together, these findings establish new model focal mouse system, showing stimuli rewards past can dynamically engage local modulation cortical maps guide flexible shifts ongoing behavior.

Язык: Английский

Процитировано

0