The claustrum is critical for maintaining working memory information DOI Open Access
Anindya S. Bhattacharjee, Chieko Huber, Burak Unsal

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

ABSTRACT Working memory (WM) enables the mammalian brain to temporarily store and manipulate information, supporting cognitive tasks communication processes 1,2 . Rather than depending on a single specialized area, WM is thought operate through distributed network spanning cortical subcortical regions 3–5 A dedicated storage area would likely require broad reciprocal connections with various accommodate diverse range of information retains. The claustrum (CLA), its extensive bidirectional neocortex 6–9 , presents compelling candidate for such role. Here, we examined involvement CLA in by recording neuronal activity mice engaged olfactory tactospatial delayed non-match-to-sample tasks. We identified cue- selective delay-specific neurons that maintained tens seconds after stimulus presentation ended. Additionally, population allowed decoding cue identity post-stimulus, although this signal gradually declined over time, aligning animal behavior. Remarkably, both chemo- optogenetic inhibition severely impaired performance across multiple types stored highlighting CLA’s critical role during encoding, delay periods, target comparison phases. These findings challenge view no essential support as an hub.

Язык: Английский

The claustrum is critical for maintaining working memory information DOI Open Access
Anindya S. Bhattacharjee, Chieko Huber, Burak Unsal

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

ABSTRACT Working memory (WM) enables the mammalian brain to temporarily store and manipulate information, supporting cognitive tasks communication processes 1,2 . Rather than depending on a single specialized area, WM is thought operate through distributed network spanning cortical subcortical regions 3–5 A dedicated storage area would likely require broad reciprocal connections with various accommodate diverse range of information retains. The claustrum (CLA), its extensive bidirectional neocortex 6–9 , presents compelling candidate for such role. Here, we examined involvement CLA in by recording neuronal activity mice engaged olfactory tactospatial delayed non-match-to-sample tasks. We identified cue- selective delay-specific neurons that maintained tens seconds after stimulus presentation ended. Additionally, population allowed decoding cue identity post-stimulus, although this signal gradually declined over time, aligning animal behavior. Remarkably, both chemo- optogenetic inhibition severely impaired performance across multiple types stored highlighting CLA’s critical role during encoding, delay periods, target comparison phases. These findings challenge view no essential support as an hub.

Язык: Английский

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