Gray matter abnormalities in sight deprivation and sight restoration DOI Creative Commons
Caterina A. Pedersini, Alessio Fracasso,

Amna Dogar

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Blindness provides a unique model for investigating brain plasticity in response to sensory deprivation. While structural changes both gray and white matter have been widely documented, particularly cases of early or congenital visual deprivation, studies traditionally focused on cortical thickness, often finding thickening posterior regions. However, other aspects integrity, such as myelin content, remain underexplored. In this study, we examined the effects deprivation structure cohort congenitally blind individuals who received eye surgery during adolescence, expanding beyond conventional measures include curvature, T1-weighted signal intensity. This multi-faceted approach offers more comprehensive view adaptations blindness valuable insights into sensory-driven plasticity, an intriguing unresolved question is whether reverses after sight restoration, enabling typical processing circuits develop despite initial period To address this, assessed effect sight-recovering changes. Critically, closure sensitive development. We did not find evidence surgery. previous study conducted same cohort, reported that notable emerged population. These results suggest alterations, rather than changes, may potentially serve biomarker following even developmental window.

Язык: Английский

Gray matter abnormalities in sight deprivation and sight restoration DOI Creative Commons
Caterina A. Pedersini, Alessio Fracasso,

Amna Dogar

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Blindness provides a unique model for investigating brain plasticity in response to sensory deprivation. While structural changes both gray and white matter have been widely documented, particularly cases of early or congenital visual deprivation, studies traditionally focused on cortical thickness, often finding thickening posterior regions. However, other aspects integrity, such as myelin content, remain underexplored. In this study, we examined the effects deprivation structure cohort congenitally blind individuals who received eye surgery during adolescence, expanding beyond conventional measures include curvature, T1-weighted signal intensity. This multi-faceted approach offers more comprehensive view adaptations blindness valuable insights into sensory-driven plasticity, an intriguing unresolved question is whether reverses after sight restoration, enabling typical processing circuits develop despite initial period To address this, assessed effect sight-recovering changes. Critically, closure sensitive development. We did not find evidence surgery. previous study conducted same cohort, reported that notable emerged population. These results suggest alterations, rather than changes, may potentially serve biomarker following even developmental window.

Язык: Английский

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