Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy DOI Creative Commons
Eliana Bianco,

Martina Bonassera,

Federico Uliana

и другие.

Molecular Cell, Год журнала: 2025, Номер 85(9), С. 1806 - 1823.e17

Опубликована: Май 1, 2025

Nutrient abundance boosts ribosome biogenesis, whereas dormancy factors limit degradation upon starvation. The equilibrium between the two pathways governs cell growth. In this study, we identified suppressor of Tom1 (Stm1) as a molecular link protection and biogenesis in Saccharomyces cerevisiae. While Stm1 was previously described factor, show that it activates Ifh1, transcriptional activator ribosomal protein genes. transiently localizes to nucleolus, where interacts with pre-ribosomes directly binds RNA Ifh1 through its C-terminal intrinsically disordered region (IDR). Although IDR is dispensable for protection, loss compromises phosphorylated nutrient starvation, which disrupts interaction Ifh1. Our findings reveal pathway sensing adjusting response availability, reinforcing relevance regulated homeostasis physiology disease.

Язык: Английский

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy DOI Creative Commons
Eliana Bianco,

Martina Bonassera,

Federico Uliana

и другие.

Molecular Cell, Год журнала: 2025, Номер 85(9), С. 1806 - 1823.e17

Опубликована: Май 1, 2025

Nutrient abundance boosts ribosome biogenesis, whereas dormancy factors limit degradation upon starvation. The equilibrium between the two pathways governs cell growth. In this study, we identified suppressor of Tom1 (Stm1) as a molecular link protection and biogenesis in Saccharomyces cerevisiae. While Stm1 was previously described factor, show that it activates Ifh1, transcriptional activator ribosomal protein genes. transiently localizes to nucleolus, where interacts with pre-ribosomes directly binds RNA Ifh1 through its C-terminal intrinsically disordered region (IDR). Although IDR is dispensable for protection, loss compromises phosphorylated nutrient starvation, which disrupts interaction Ifh1. Our findings reveal pathway sensing adjusting response availability, reinforcing relevance regulated homeostasis physiology disease.

Язык: Английский

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