Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome DOI Creative Commons
Costas Papatheodoropoulos

Biology, Год журнала: 2025, Номер 14(4), С. 363 - 363

Опубликована: Март 31, 2025

The excitation/inhibition (E/I) balance is a critical feature of neural circuits, which crucial for maintaining optimal brain function by ensuring network stability and preventing hyperexcitability. hippocampus exhibits the particularly interesting characteristics having different functions E/I profiles between its dorsal ventral segments. Furthermore, vulnerable to epilepsy implicated in Fragile X Syndrome (FXS), disorders associated with heightened possible deficits GABA-mediated inhibition. In epilepsy, shows susceptibility seizures, while FXS, recent evidence suggests differential alterations excitability inhibition regions. This article explores mechanisms underlying regulation, focusing on emphasizing that may confer homeostatic flexibility balance. Notably, adult FXS models enhanced GABAergic inhibition, resistance epileptiform activity, physiological pattern (sharp wave-ripples, SWRs), potentially representing adaptation. contrast, these more aberrant discharges displays altered SWRs. These findings highlight complex, region-specific nature disruptions neurological suggest possess unique compensatory mechanisms. Specifically, it proposed hippocampus, region most prone hyperexcitability, have adaptive capabilities at cellular levels maintain within normal range prevent transition hyperexcitability preserve function. Investigating responses their developmental trajectories offer novel insights into strategies mitigating imbalances other neuropsychiatric neurodevelopmental disorders.

Язык: Английский

Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome DOI Creative Commons
Costas Papatheodoropoulos

Biology, Год журнала: 2025, Номер 14(4), С. 363 - 363

Опубликована: Март 31, 2025

The excitation/inhibition (E/I) balance is a critical feature of neural circuits, which crucial for maintaining optimal brain function by ensuring network stability and preventing hyperexcitability. hippocampus exhibits the particularly interesting characteristics having different functions E/I profiles between its dorsal ventral segments. Furthermore, vulnerable to epilepsy implicated in Fragile X Syndrome (FXS), disorders associated with heightened possible deficits GABA-mediated inhibition. In epilepsy, shows susceptibility seizures, while FXS, recent evidence suggests differential alterations excitability inhibition regions. This article explores mechanisms underlying regulation, focusing on emphasizing that may confer homeostatic flexibility balance. Notably, adult FXS models enhanced GABAergic inhibition, resistance epileptiform activity, physiological pattern (sharp wave-ripples, SWRs), potentially representing adaptation. contrast, these more aberrant discharges displays altered SWRs. These findings highlight complex, region-specific nature disruptions neurological suggest possess unique compensatory mechanisms. Specifically, it proposed hippocampus, region most prone hyperexcitability, have adaptive capabilities at cellular levels maintain within normal range prevent transition hyperexcitability preserve function. Investigating responses their developmental trajectories offer novel insights into strategies mitigating imbalances other neuropsychiatric neurodevelopmental disorders.

Язык: Английский

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