Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2774 - 2774
Опубликована: Март 19, 2025
Anxiety
is
a
physiological,
emotional
response
that
anticipates
distal
threats.
When
kept
under
control,
anxiety
beneficial
response,
helping
animals
to
maintain
heightened
attention
in
environments
with
potential
dangers.
However,
an
overestimation
of
threats
can
lead
excessive
expression
that,
humans,
may
evolve
into
disorders.
Pharmacological
treatments
show
variable
efficacy
among
patients,
highlighting
the
need
for
more
efforts
better
understand
pathogenesis
Mounting
evidence
suggests
astrocytes,
type
glial
cells,
are
active
partners
neurons
brain
circuits
and
regulation
behaviors
both
physiological
pathological
conditions.
In
this
review,
I
summarize
current
literature
on
role
astrocytes
from
different
regions
modulating
anxious
states,
goal
exploring
novel
cerebral
mechanisms
identify
innovative
therapeutic
targets
treatment
Язык: Английский
A sensitive period for the development of episodic-like memory in mice
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Episodic-like
memory
is
a
later-developing
cognitive
function
supported
by
the
hippocampus.
In
mice,
formation
of
extracellular
perineuronal
nets
in
subfield
CA1
dorsal
hippocampus
controls
emergence
episodic-like
during
fourth
postnatal
week
(Ramsaran
et
al.,
2023).
Whether
timing
onset
hard-wired,
or
flexibly
set
early-life
experiences
critical
sensitive
period
for
hippocampal
maturation,
unknown.
Here,
we
show
that
trajectories
development
vary
mice
given
different
sets
spanning
second
and
third
weeks.
Specifically,
precision
developed
later
experienced
adversity,
while
it
earlier
enrichment.
Moreover,
demonstrate
modulating
pace
net
CA1.
These
results
indicate
undergoes
which
determine
development.
Язык: Английский