Effects of the ketogenic diet on bone health: A systematic review

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Фев. 2, 2023

To carry out a systematic review of published studies to evaluate the relationship between different type ketogenic diet (KD) and bone health as supported by scientific literature.The study involved all articles that assessed use KD for treatment overweight or obesity health. The quality assessment was evaluated with using Cambridge Quality Checklists. search strategy included following combination Medical Subjects Headings terms keywords: "osteoporosis", "bone health, function", mineral density", "ketogenic diet".Seven trials were identified reviewed. No significant changes in mass density (BMD) observed after KD. results showed no effect on resorption measuring urinary N-telopeptide levels, formation bone-specific alkaline phosphatase, alterations overall turnover patients who followed Only female subject 10% weight loss, increases while new synthesis decreases, but without increasing risk osteoporosis. Finally, lost significantly more than controls, associated an increase serum vitamin D levels reduction plasma parathyroid hormone (PTH) levels.No human have currently been conducted adequate powerful experimental designs definitively understand impact therapy

Язык: Английский

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Obesity and Weight Loss Strategies for Patients With Heart Failure

JACC Heart Failure, Год журнала: 2024, Номер 12(9), С. 1509 - 1527

Опубликована: Июль 31, 2024

Язык: Английский

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Obesity and micronutrients deficit, when and how to suplement

Food and Agricultural Immunology, Год журнала: 2024, Номер 35(1)

Опубликована: Авг. 2, 2024

Since the 1990s worldwide rate of obesity has escalated significantly. This overflow affects all demographic groups, with a notable impact on older adults and women. Obesity is associated variety serious chronic health conditions. Additionally, it linked to endocrine disorders such as hypothyroidism subclinical hypothyroidism. review analyzes connection between micronutrient levels, particularly focusing vitamin D, evaluates potential nutritional supplementation approaches for this population.

Язык: Английский

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The interplay of factors in metabolic syndrome: understanding its roots and complexity

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Дек. 27, 2024

Abstract Metabolic syndrome (MetS) is an indicator and diverse endocrine that combines different metabolic defects with clinical, physiological, biochemical, factors. Obesity, visceral adiposity abdominal obesity, dyslipidemia, insulin resistance (IR), elevated blood pressure, endothelial dysfunction, acute or chronic inflammation are the risk factors associated MetS. Abdominal a hallmark of MetS, highlights dysfunctional fat tissue increased for cardiovascular disease diabetes. Insulin, vital peptide hormone, regulates glucose metabolism throughout body. When cells become resistant to insulin’s effects, it disrupts various molecular pathways, leading IR. This condition linked range disorders, including diabetes, fatty liver disease, polycystic ovary syndrome. Atherogenic dyslipidemia characterized by three key factors: high levels small, low-dense lipoprotein (LDL) particles triglycerides, alongside low high-density (HDL), “good” cholesterol. Such combination major player in where IR driving force. contributes significantly development atherosclerosis, which can lead disease. On top that, genetic alteration lifestyle such as diet exercise influence complexity progression To enhance our understanding consciousness, essential understand fundamental pathogenesis review current advancements MetS research involvement gut microbiome, epigenetic regulation, metabolomic profiling early detection Mets. In addition, this emphasized epidemiology factors, their preventive measures. The goal effort deepen encourage further develop effective strategies preventing managing complex diseases.

Язык: Английский

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The Future of Obesity Management through Precision Nutrition: Putting the Individual at the Center

Current Nutrition Reports, Год журнала: 2024, Номер 13(3), С. 455 - 477

Опубликована: Май 28, 2024

Abstract Purpose of Review The prevalence obesity continues to rise steadily. While management typically relies on dietary and lifestyle modifications, individual responses these interventions vary widely. Clinical guidelines for overweight stress the importance personalized approaches care. This review aims underscore role precision nutrition in delivering tailored management. Recent Findings technological strides have expanded our ability detect obesity-related genetic polymorphisms, with machine learning algorithms proving pivotal analyzing intricate genomic data. Machine can also predict postprandial glucose, triglyceride, insulin levels, facilitating customized ultimately leading successful weight loss. Additionally, given that adherence recommendations is one key predictors loss success, employing more objective methods assessment monitoring enhance sustained long-term compliance. Summary Biomarkers food intake hold promise a assessment. Acknowledging multifaceted nature obesity, stands poised transform by tailoring individuals' backgrounds, gut microbiota, metabolic profiles, behavioral patterns. However, there insufficient evidence demonstrating superiority over traditional recommendations. integration into routine clinical practice requires further validation through randomized controlled trials accumulation larger body strengthen its foundation.

Язык: Английский

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Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 729, С. 150344 - 150344

Опубликована: Июль 3, 2024

Язык: Английский

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Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women

Nutrients, Год журнала: 2025, Номер 17(1), С. 169 - 169

Опубликована: Янв. 2, 2025

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women. Methods: Random allocation sixty-one participants into four groups: early plus (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 13.40 kg, 33.5 5.53 kg/m2), late (LTRE-PA, 30.60 7.94 94.45 15.36 34.37 7.09 only (LTRE, 27.93 9.79 88.32 10.36 32.71 5.15 kg/m2) control group (CG, 36.25 11.52 89.01 11.68 33.66 6.18 kg/m2). The intervention lasted for 12 weeks all groups. Both ETRE-PA LTRE-PA groups engaged rigorous aerobic resistance-training program. Results: Significant reductions body weight mass index were observed compared to CG LTRE post-intervention (p < 0.0005). Only exhibited significant decrease fat 0.02), low-density lipoprotein cholesterol 0.01), aspartate aminotransferase 0.002). alanine levels 0.004) 0.02) These two latter achieved higher performances 6-min walking test, bench press, 30-s squat, crunch vertical jump 0.0005 both), leg extension 0.02 both) when Conclusion: integration TRE PA leads greater improvements composition, lipid profile, performance, no differences between approaches. This strategy offers promising solution

Язык: Английский

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The impact and utility of very low-calorie diets: the role of exercise and protein in preserving skeletal muscle mass

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2023, Номер 26(6), С. 521 - 527

Опубликована: Сен. 7, 2023

Purpose of review Very low-calorie diets (VLCD) are used as a weight loss intervention, but concerns have been raised about their potential negative impact on lean mass. Here, we the available evidence regarding effects VLCD mass and explore utility strategies to mitigate reductions in skeletal muscle. Recent findings We observed that VLCD, despite mass, may be suitable certain populations risk reducing The extent reduction depend various factors, such duration degree energy deficit diet, well individual's starting overall health. Summary viable option populations; however, priority needs given resistance exercise training, secondarily adequate protein intake should part this dietary regime losing muscle

Язык: Английский

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Systematic review of mediterranean diet interventions in menopausal women

AIMS Public Health, Год журнала: 2024, Номер 11(1), С. 110 - 129

Опубликована: Янв. 1, 2024

<abstract> <p>The increasing lifespan of women and their extended time spent in menopause pose significant challenges for health care systems, primarily due to the impacts postmenopausal estrogen deficiency aging on health. Menopause's onset is linked a heightened prevalence obesity, metabolic syndrome, cardiovascular disease, osteoporosis. Diet particularly relevant during given its impact quality life longevity modifiability. Because Mediterranean diet currently regarded as one healthiest dietary models world, aim this systematic review was assess current evidence regarding effectiveness studies an intervention menopausal women. A intervention-based involving among performed Scopus, PubMed, Web Science. The results seven that met inclusion criteria suggests adherence can have beneficial women's health, including reductions weight, blood pressure, ω6: ω3 ratio, triglycerides, total cholesterol, LDL levels. Those seem be public interventions aimed at improving life.</p> </abstract>

Язык: Английский

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Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

Nutrients, Год журнала: 2023, Номер 15(16), С. 3582 - 3582

Опубликована: Авг. 15, 2023

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Hyperandrogenism, hyperinsulinism and insulin resistance (IR) are main drivers clinical, metabolic phenotypes PCOS. In adolescence, cornerstones PCOS treatment lifestyle dietary interventions. particular, quality quantity carbohydrates introduced with diet play a crucial role benefits on Recently, ketogenic (KD) has attracted significant interest for IR control carbohydrate metabolism, which proven to be beneficial several dysmetabolic conditions, including The goal KD induce fasting-like metabolism production chetonic bodies. Ketosis good regulator calorie intake mimics starvation effect body, leading body weight consequent metabolism. Additionally, during ketogenesis, receptor sensitivity also promoted. We proposed broad overview available literature regarding indications considered its useful improving management. reported data support that low-calorie (LCKD) plays positive as weight, IR, glucose lipid homeostasis hormonal profile. Unfortunately, evidence concerning very LCKD adolescents excessive still numerically scarce. Further studies necessary understand whether these effects due loss or nutritional characteristics this diet. Considering long-term consequences PCOS, it detect prospects interventions protect fertility, starting adolescence.

Язык: Английский

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