Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C

Clinical and Molecular Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Background/Aims: Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV).This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic (CHC).Methods: This multicenter, retrospective included 8,819 diagnosed CHC who were treated DAAs and achieved a sustained virological response (SVR) between January 2014 December 2022.Fibrosis was defined as 20% reduction noninvasive surrogates for liver fibrosis, such stiffness (LS) measured by vibrationcontrolled transient elastography (VCTE) fibrosis-4 (FIB-4) score.Hypercholesterolemia (h-TC) >200 mg/dL. Results:The median age population 59.6 years, predominance male (n = 4,713, 57.3%).Genotypes 1, 2, others confirmed 3,872 (46.2%), 3,487 (41.6%), 1,024 (12.2%) patients, respectively.Diabetes mellitus (DM) present 1,442 (17.2%) LS 7.50 kPa (interquartile range, 5.30-12.50).Multivariate analysis revealed that presence DM pre-DAA h-TC independently associated decreased probability VCTE Additionally, FIB-4. Conclusions: Metabolic has an unfavorable influence on inpatients achieve SVR treatment.

Язык: Английский

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Body fat changes and risk of new onsets of hypertension and hyperlipidaemia among Korean adults: a longitudinal study

Clinical Medicine, Год журнала: 2025, Номер unknown, С. 100293 - 100293

Опубликована: Фев. 1, 2025

This study examined the association between changes in body fat, mass index (BMI), and risk of newly developed hypertension hyperlipidaemia general population. longitudinal included 17,598 individuals without prior who underwent at least three health examinations January 2015 December 2022. Body fat was classified as decreased (≥ 5 %), stable (within increased %) using bioelectrical impedance analysis. The BMI categorised non-obese (BMI < 23), overweight (23 ≤ 25), obese ≥ 25). Hypertension were identified through self-reported medication use or clinical measurements. Increases associated with higher incidence rates hyperlipidaemia. Decreased a lower (Odds ratio: 0.638, 95 % confidence interval: 0.464-0.876) groups (0.724, 0.577-0.909). Non-obese had than (87.2 vs 66.4 per 1,000 people). Compared to group, raised (non-obese: 1.522, 1.248-1.855; overweight: 1.278, 1.032-1.583; obese: 1.214, 1.028-1.433). Overweight demonstrated (0.546, 0.400-0.747). Increased hyperlipidaemia, even within same category. Decreasing particularly individuals, is

Язык: Английский

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Metabolic dysfunction-associated steatotic liver disease increases cardiovascular disease risk in young adults

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 17, 2025

Язык: Английский

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The effects of smoking, alcohol consumption, obesity, and physical inactivity on healthcare costs: a longitudinal cohort study

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 5, 2025

Research indicates major risk factors including smoking, alcohol consumption, obesity and physical inactivity contribute significantly to global disease burden healthcare costs. However, these studies have challenges, such as increased bias uncertainty arising from use of population attributable fractions (PAF) the issue reverse causality in cross-sectional data. This study aims evaluate long-term costs associated with behaviors using a longitudinal cohort. cohort used Korean National Health Insurance Service-National Sample Cohort database (NHIS-NSC 2.0), covering 2002-2019. The included individuals aged 40-69 years who underwent health examinations 2002-2004 had no pre-existing factor-related diseases. Cumulative during 2010-2019 were analyzed generalized linear model log-link function gamma distribution, adjusted for other sociodemographic factors. Smoking, obesity, both sexes. Male current smokers incurred 13.8% higher than never-smokers, while female spent 18.6% more. Former lower smokers, reductions 9.9% males 13.2% females. Almost daily consumption raised by 21.4% 31.8% Costs varied BMI categories, severe increasing expenditures 26.9% 46.5% females compared normal weight. Overweight status showed contrasting effects between sexes, 3.4% decrease but 7.6% increase Exercising 1-4 times weekly reduced 7.4% non-exercisers. underscores economic impact supports need targeted public interventions. findings highlight importance interventions high-risk groups reducing

Язык: Английский

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Abdominal obesity and the risk of young-onset dementia in women: a nationwide cohort study

Alzheimer s Research & Therapy, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 21, 2025

The association between obesity and young-onset dementia (YOD, defined as diagnosed before age 65) is established, but the specific impact of abdominal in women remains unclear. Abdominal obesity, driven by excess visceral fat, may increase risk through metabolic vascular pathways. We investigated YOD using a large nationwide cohort. analyzed 964,536 Korean aged 40-60 years who underwent national health checkups 2009. General was body mass index (BMI), categorized waist circumference (WC) into < 75 cm, 76-84 85-94 ≥ 95 cm. identified ICD-10 codes medication prescriptions. Hazard ratios (HRs) for were estimated multivariable Cox proportional hazard models adjusted lifestyle clinical factors. Over median follow-up 8.2 years, incidence increased progressively with higher WC. Women WC cm had 55% (HR 1.55; 95% CI 1.34-1.79) compared to those particularly strong (VD), HR 1.83 (95% 1.30-2.57). By contrast, BMI showed U-shaped relationship, lowest observed normal (18.5-22.9 kg/m²), significantly elevated risks both underweight (BMI 18.5 kg/m²; 1.39, 1.13-1.71) morbidly obese 30 1.26, 1.10-1.45). significant, independent factor women, VD. These findings underscore importance addressing middle-aged reduce risk.

Язык: Английский

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The role of incretin receptor agonists in the treatment of obesity

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(10), С. 4178 - 4196

Опубликована: Июль 29, 2024

Abstract Introdroduction Obesity and its associated metabolic conditions have become a significant global health problem in recent years, with many people living obesity fulfilling criteria for pharmacological treatment. The development of the glucagon‐like peptide‐1 receptor agonists chronic weight management has triggered new interest incretins other hormones as targets obesity, investigations into dual triple co‐agonists. Methods objective this narrative review was to summarize available data on approved emerging incretin‐based agents treatment obesity. Results In clinical trials currently overweight or loss between 6% 21% baseline body been observed, 23% 94% participants achieving 10% higher loss, depending study agent used. Favourable outcomes also seen regard cardiovascular risk outcomes, diabetes prevention, dysfunction‐associated steatotic liver disease/steatohepatitis prevention regain after surgery. Limitations these include high costs, potential once is stopped, lean mass gastrointestinal adverse events; issues respect gallbladder biliary diseases require further investigation. Conclusions Many co‐agonists are still development, more needed assess efficacy, safety tolerability therapies versus established therapies; however, promising, results eagerly awaited.

Язык: Английский

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Current State of Pharmacotherapy in Obesity

Korean Journal of Gastroenterology, Год журнала: 2024, Номер 83(3), С. 94 - 101

Опубликована: Март 25, 2024

The prevalence of obesity with various complications is increasing rapidly in Korea.Although lifestyle modification fundamental treatment, more effective treatment tools are required.Many advances have been reported recently, including modifications and pharmacological, endoscopic, surgical treatments.Drugs proven long-term efficacy safety preferred because management for a process.Currently, four medications available use Korea: Orlistat, Naltrexone/bupuropion NR, Phentermine/topiramate capsule, Liraglutide.Recently, semaglutide tirzepatide attracting attention their effectiveness convenience, but they not yet Korea.In addition, there limitations such as the yo-yo effect when discontinuing drug, safety, cost.Patients medical staff must be aware advantages side effects each medication to ensure successful obesity.(

Язык: Английский

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Tirzepatide ameliorates eating behaviors regardless of prior exposure to glucagon-like peptide receptor agonists in Japanese patients with type 2 diabetes mellitus

Journal of Diabetes and its Complications, Год журнала: 2024, Номер 38(7), С. 108779 - 108779

Опубликована: Май 29, 2024

To investigate effects of tirzepatide, a dual receptor agonist for glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1), on eating behaviors.

Язык: Английский

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Different modifiable risk factors for the development of non-advanced adenoma, advanced adenomatous lesion, and sessile serrated lesions, on screening colonoscopy

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 23, 2024

The development of premalignant colorectal polyps is significantly influenced by various lifestyle and modifiable risk factors. In our study, we used a large cohort 9025 patients, who underwent screening colonoscopies at university hospital, to assess the factors associated with three different cancer precursor lesions: non-advanced adenomas (NAs), advanced adenomatous lesions (ADLs), sessile serrated (SSLs). Among participants, 3641 had NAs, 836 ADLs, 533 SSLs. We identified obesity, current smoking, appendicular skeletal muscle mass as that increase NAs ADLs (all P < 0.05). Furthermore, found positive correlation between degree obesity an increased developing for trend 0.001), while non-smoking was decreased (P 0.001 0.003, respectively). Smoking only factor SSLs (adjusted odds ratio [aOR] 1.58; 95% confidence interval [CI] 1.20-2.07), even higher in patients metabolic syndrome (aOR 1.71; CI 1.05-2.77). Addressing such smoking could play important role reducing both lesions. cessation especially it significant

Язык: Английский

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Clinical Characteristics of Patients With Statin Discontinuation in Korea: A Nationwide Population-Based Study

Journal of Lipid and Atherosclerosis, Год журнала: 2024, Номер 13(1), С. 41 - 41

Опубликована: Янв. 1, 2024

To investigate the clinical characteristics of patients with statin discontinuation in Korea, using a nationwide database.

Язык: Английский

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