The relationship between nonalcoholic fatty liver disease and frailty: A systematic review and meta-analysis
Diabetes & Metabolic Syndrome Clinical Research & Reviews,
Год журнала:
2025,
Номер
19(2), С. 103187 - 103187
Опубликована: Янв. 7, 2025
Язык: Английский
Association of triglyceride-glucose index with bone mineral density and fracture: a systematic review
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Март 4, 2025
Studies
have
found
inconsistent
results
regarding
triglyceride-glucose
(TyG)
index
and
bone
health.
This
systematic
review
aims
to
synthesize
the
existing
evidence
on
association
between
index,
mineral
density
(BMD),
fractures.
A
comprehensive
search
of
PubMed,
Scopus,
Web
Science,
Embase
databases
was
performed
for
studies
published
up
December
26,
2024.
Inclusion
criteria
encompassed
human
examining
TyG
in
relation
BMD
or
The
risk
bias
assessed
using
Newcastle-Ottawa
Scale
(NOS).
Data
synthesis
included
both
qualitative
descriptive
statistical
analyses.
From
201
identified,
12
met
inclusion
comprising
817,242
participants.
Most
reported
a
significant
findings
BMD.
While
some
no
correlation
individuals
aged
≥
50
years,
general
population
18
years
demonstrated
Variations
age
study
populations,
presence
diabetes,
BMI,
adjustment
factors
likely
contributed
these
discrepancies.
Further
research
is
needed
clarify
role
health
its
potential
utility
as
surrogate
marker.
associated
with
fractures
can
serve
marker
osteoporosis
populations
rather
than
exclusively
elderly.
Язык: Английский
Association between the Triglyceride-glucose index and fragility fractures among US adults: insights from NHANES
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Март 22, 2025
The
triglyceride-glucose
(TyG)
index,
a
recognized
marker
for
insulin
resistance,
holds
potential
implications
skeletal
health.
However,
its
relationship
with
fragility
fractures
remains
uncertain.
We
aimed
to
elucidate
the
association
between
TyG
index
and
in
general
US
population.
Cross-sectional
data
of
25,082
participants
were
obtained
from
National
Health
Nutrition
Examination
Survey.
was
investigated
using
univariate
weighted
multivariate
logistic
regression
as
well
restricted
cubic
spline
(RCS)
models.
least
absolute
shrinkage
selection
operator
ten-fold
cross-validation
employed
identify
key
variables,
leading
development
nomogram
model.
Calibration
receiver
operating
characteristic
curves
utilized
evaluate
model's
validity.
overall
prevalence
among
1.10%.
After
adjusting
confounders,
exhibited
robust
risk
(odds
ratio,
1.94;
95%
confidence
interval,
1.31–2.88;
P
<
0.001).
RCS
demonstrated
positive
linear
fractures.
predictive
nomogram,
incorporating
other
clinical
factors,
favorable
performance
(consistency
=
0.901).
Elevated
levels
significantly
correlated
These
findings
suggest
that
may
serve
fractures,
underscoring
importance
early
intervention
improved
fracture
assessment
tools
practice.
Язык: Английский
Nonlinear associations between METS-IR and all-cause as well as cardiovascular mortality in adults with osteoporosis and osteopenia: evidence from NHANES 2007–2023
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
Osteoporosis
is
a
systemic
metabolic
bone
disorder
characterized
by
decrease
in
mass
and
the
degradation
of
microarchitecture.
Nevertheless,
precise
influence
core
marker
syndrome-insulin
resistance-on
prognosis
patients
with
osteoporosis
osteopenia
remains
insufficiently
understood.
This
study
seeks
to
clarify
association
between
novel
insulin
resistance
metric,
METS-IR,
risks
all-cause
cardiovascular
mortality
among
individuals
diagnosed
OP.
utilizes
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
collected
2007
2023,
employing
multivariable
Cox
proportional
hazards
regression
models
restricted
cubic
splines
investigate
METS-IR
index
risk
osteopenia.
Furthermore,
subgroup
analyses
were
performed
identify
potential
effect
modifications
high-risk
subpopulations.
The
cohort
included
2175
osteopenia,
followed
for
16
years,
during
which
468
deaths
102
cardiovascular-related
documented.
identified
nonlinear
positive
However,
no
significant
was
observed
mortality.
At
threshold
2.3,
hazard
ratio
reached
1,
indicating
shift
low
high.
demonstrated
stronger
elevated
levels
or
comorbid
diabetes,
while
such
relationship
found
highlights
whereas
These
findings
enhance
understanding
resistance's
role
its
comorbidities,
particularly
relation
underscores
importance
managing
improve
overall
survival
outcomes,
further
studies
are
needed
explore
specific
impacts
on
outcomes.
Язык: Английский
The association between the AST/ALT ratio and osteopenia or osteoporosis in patients with type 2 diabetes mellitus
Endocrine Connections,
Год журнала:
2025,
Номер
14(5)
Опубликована: Апрель 25, 2025
The
aim
of
this
study
was
to
investigate
the
relationship
between
AST/ALT
ratio
and
osteopenia
or
osteoporosis
in
patients
with
type
2
diabetes
mellitus
(T2DM).
A
total
589
T2DM
were
divided
into
two
groups
based
on
T-score:
T-score
≥
-1.0
group,
normal
bone
mineral
density
<
(OP).
association
osteopenia/OP
evaluated
by
multivariate
analyses.
receiver
operating
characteristic
(ROC)
curves
used
estimate
diagnostic
performance
according
area
under
ROC
curve
(AUC).
group
showed
significantly
higher
level
than
those
(0.93
±
0.16
vs
1.17
0.24,
P
0.001).
According
interquartile
range
ratio,
participants
four
groups:
Q1
(0.650,
0.874),
Q2
(0.875,
0.999),
Q3
(1.000,
1.173)
Q4
(1.174,
1.917).
After
adjustment
for
confounding
factors,
compared
level,
subjects
remained
more
likely
have
(Q3,
OR
3.478,
95%
CI
1.641-7.411;
Q4,
15.278,
6.377-36.837).
provided
an
AUC
value
0.81
(95%
0.77-0.84)
T2DM.
An
elevated
is
associated
risk
a
practical
cost-effective
biomarker,
may
be
potential
predictor
Язык: Английский