Roles of intestinal Parabacteroides in human health and diseases

FEMS Microbiology Letters, Год журнала: 2022, Номер 369(1)

Опубликована: Янв. 1, 2022

Abstract The stability of gut microbiota is essential for the host's health. Parabacteroides spp., core members human microbiota, have an average abundance 1.27% in humans 12 populations. recently been reported to a close relationship with host health (e.g. metabolic syndrome, inflammatory bowel disease and obesity). physiological characteristics carbohydrate metabolism secreting short chain fatty acids. However, antimicrobial resistance antibiotics (such as clindamycin, moxifloxacin cefoxitin) should not be ignored. In this review, we primarily focus on distasonis, goldsteinii, johnsonii merdae discuss their relationships disease, diet prevention or induction diseases. Pa. distasonis goldsteinii may viewed potential next generation probiotic candidates due protective effects inflammation obesity mice. We also therapeutic application spp. maintaining host–intestine homeostasis.

Язык: Английский

---

SeqCode: a nomenclatural code for prokaryotes described from sequence data

Nature Microbiology, Год журнала: 2022, Номер unknown

Опубликована: Сен. 19, 2022

Abstract Most prokaryotes are not available as pure cultures and therefore ineligible for naming under the rules recommendations of International Code Nomenclature Prokaryotes (ICNP). Here we summarize development SeqCode, a code nomenclature which genome sequences serve nomenclatural types. This enables valid publication names based upon isolate genome, metagenome-assembled or single-amplified sequences. Otherwise, it is similar to ICNP with regard formation priority. It operates through SeqCode Registry ( https://seqco.de/ ), registration portal types registered, validated linked metadata. We describe two paths currently within register validate names, including Candidatus provide examples both. Recommendations on minimal standards DNA provided. Thus, provides reproducible objective framework all regardless cultivability facilitates communication across microbiological disciplines.

Язык: Английский

---

The microbial ecology of Escherichia coli in the vertebrate gut

FEMS Microbiology Reviews, Год журнала: 2022, Номер 46(3)

Опубликована: Фев. 2, 2022

Escherichia coli has a rich history as biology's 'rock star', driving advances across many fields. In the wild, E. resides innocuously in gut of humans and animals but is also versatile pathogen commonly associated with intestinal extraintestinal infections antimicrobial resistance-including large foodborne outbreaks such one that swept Europe 2011, killing 54 individuals causing approximately 4000 900 cases haemolytic uraemic syndrome. Given most are harmless colonizers, an important ecological question plaguing microbiologists what makes occasionally devastating pathogen? To address this requires enhanced understanding ecology organism commensal. Here, we review how our knowledge within-host diversity vertebrate progressed 137 years since was first described. We current approaches to study bacterial diversity. closing, discuss some outstanding questions yet be addressed prospects for future research.

Язык: Английский

---

Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function

Nutrients, Год журнала: 2024, Номер 16(16), С. 2660 - 2660

Опубликована: Авг. 12, 2024

The gut microbiota are mainly composed of

Язык: Английский

---

The influence of Akkermansia muciniphila on intestinal barrier function

Gut Pathogens, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 3, 2024

Intestinal barriers play a crucial role in human physiology, both homeostatic and pathological conditions. Disruption of the intestinal barrier is significant factor pathogenesis gastrointestinal inflammatory diseases, such as bowel disease. The profound influence gut microbiota on diseases has sparked considerable interest manipulating it through dietary interventions, probiotics, fecal transplantation potential approaches to enhance integrity barrier. Numerous studies have underscored protective effects specific their associated metabolites. In recent years, an increasing body research demonstrated that Akkermansia muciniphila (A. muciniphila, Am) plays beneficial various including diabetes, obesity, aging, cancer, metabolic syndrome. It gaining popularity regulator influences flora recognized 'new generation probiotics'. Consequently, may represent target promising therapy option for diseases. This article systematically summarizes Am gut. Specifically, we carefully discuss key scientific issues need resolution future regarding bacteria represented by Am, which provide insights application drugs targeting clinical treatment.

Язык: Английский

---

Expanding the human gut microbiome atlas of Africa

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Population studies provide insights into the interplay between gut microbiome and geographical, lifestyle, genetic environmental factors. However, low- middle-income countries, in which approximately 84% of world's population lives1, are not equitably represented large-scale research2-4. Here we present AWI-Gen 2 Microbiome Project, a cross-sectional study sampling 1,801 women from Burkina Faso, Ghana, Kenya South Africa. By engaging with communities that range rural horticultural to post-industrial urban informal settlements, capture far greater breadth diversity. Using shotgun metagenomic sequencing, identify taxa geographic lifestyle associations, including Treponema Cryptobacteroides species loss Bifidobacterium gain populations. We uncover 1,005 bacterial metagenome-assembled genomes, antibiotic susceptibility as factor might drive succinifaciens absence Finally, find an HIV infection signature defined by several previously associated HIV, Dysosmobacter welbionis Enterocloster sp. This represents largest population-representative survey metagenomes African individuals so far, paired extensive clinical biomarkers demographic data, provides opportunity for microbiome-related discovery.

Язык: Английский

---

Metagenome-assembled genomes and gene catalog from the chicken gut microbiome aid in deciphering antibiotic resistomes

Communications Biology, Год журнала: 2021, Номер 4(1)

Опубликована: Ноя. 18, 2021

Abstract Gut microbial reference genomes and gene catalogs are necessary for understanding the chicken gut microbiome. Here, we assembled 12,339 constructed a catalog consisting of ~16.6 million genes by integrating 799 public microbiome samples from ten countries. We found that 893 38 metagenome-assembled (MAGs) in our dataset were putative novel species genera, respectively. In gut, Lactobacillus aviarius crispatus most common lactic acid bacteria, glycoside hydrolases abundant carbohydrate-active enzymes (CAZymes). Antibiotic resistome profiling results indicated Chinese harbored higher relative abundance but less diversity antimicrobial resistance (ARGs) than European samples. also proposed effects geography host on resistome. Our study provides largest integrated metagenomic to date demonstrates its value exploring genes.

Язык: Английский

---

The microbiome of the buffalo digestive tract

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Фев. 10, 2022

Abstract Buffalo is an important livestock species. Here, we present a comprehensive metagenomic survey of the microbial communities along buffalo digestive tract. We analysed 695 samples covering eight different sites in three compartments (four-chambered stomach, intestine, and rectum). mapped ~85% raw sequence reads to 4,960 strain-level metagenome-assembled genomes (MAGs) 3,255 species-level MAGs, 90% which appear correspond new In addition, annotated over 5.8 million nonredundant proteins from MAGs. comparison with rumen microbiome cattle, microbiota seems greater potential for fibre degradation less methane production. Our catalogue encoded provides insights into functions interactions at distinct

Язык: Английский

---

Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential

Nature Reviews Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Язык: Английский

---

Identification of an epilepsy-linked gut microbiota signature in a pediatric rat model of acquired epilepsy

Neurobiology of Disease, Год журнала: 2024, Номер 194, С. 106469 - 106469

Опубликована: Март 13, 2024

A dysfunctional gut microbiota-brain axis is emerging as a potential pathogenic mechanism in epilepsy, particularly pediatric forms of epilepsy. To add new insights into gut-related changes acquired epilepsy that develops early life, we used multi-omics approach rat model with 56% incidence The presence spontaneous seizures was assessed adult rats (n = 46) 5 months after status epilepticus induced by intra-amygdala kainate at postnatal day 13, 2 weeks (24/7) ECoG monitoring. Twenty-six developed (Epi) while the remaining 20 (No-Epi) did not show seizures. At end monitoring, all and their sham controls 20) were sacrificed for quantitative histopathological immunohistochemical analyses structure, glia macrophages, well RTqPCR analysis inflammation/oxidative stress markers. By comparing Epi, No-Epi rats, controls, found structural, cellular, molecular alterations reflecting gut, which specifically associated In particular, villus height-to-crypt depth ratio number Goblet cells reduced duodenum Epi vs both (p < 0.01). Villus height crypt jejunum 0.01) increased controls. We also detected enhanced Iba1-positive together IL1b NFE2L2 transcripts TNF protein, small intestine control 0.01), denoting inflammation oxidative stress. Astroglial GFAP-immunostaining similar experimental groups. Metagenomic feces collected showed two dominant phyla (Bacteroidota-to-Firmicutes) similarly rats. Notably, relative abundance families, genera species SCFA production differed describing bacterial imprint Furthermore, blood metabolic signature characterized lipid metabolism compared to Our study provides evidence long-term alterations, along microbiota-related changes, occurring develop brain injury life.

Язык: Английский

---