Food Science & Nutrition,
Год журнала:
2024,
Номер
12(11), С. 9238 - 9251
Опубликована: Сен. 30, 2024
Abstract
Resveratrol,
a
natural
compound
found
in
various
plants,
is
known
for
its
anti‐inflammatory,
antioxidant,
and
senescence‐delaying
properties.
RNA
N6‐methyladenosine
(m6A)
methylation
plays
crucial
role
oxidative
stress
premature
cellular
senescence
processes
closely
associated
with
age‐related
disorders.
However,
the
anti‐premature
via
m6A
mechanism
of
resveratrol
still
not
fully
understood.
In
this
study,
based
on
model
human
embryonic
lung
fibroblasts
(HEFs)
induced
by
hydrogen
peroxide
(H
2
O
),
widely
accepted
caused
stress,
we
explored
anti‐aging
regulatory
effects
at
level.
Our
data
suggested
that
significantly
delayed
increasing
cell
viability,
reducing
SA‐β‐gal
blue
staining
rate,
ROS
levels,
senescence‐associated
secretory
phenotypes
(SASP)
expression
HEFs.
Meanwhile,
increased
whole
methyltransferases
activity
overall
level
during
senescence.
Furthermore,
three
genes
CCND2
,
E2F1
GADD45B
have
been
identified
as
main
ones
regulating
resveratrol.
Specifically,
it
decreased
level,
cells.
study
provided
new
clues
exploring
application
field
aging.
Science China Life Sciences,
Год журнала:
2024,
Номер
67(10), С. 2105 - 2119
Опубликована: Май 27, 2024
Abstract
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
emerged
as
a
prominent
global
health
concern
associated
with
high
risk
of
metabolic
syndrome,
and
impacted
substantial
segment
the
population.
The
spectrum
ranges
from
simple
to
non-alcoholic
steatohepatitis
(NASH),
which
can
progress
cirrhosis
hepatocellular
carcinoma
(HCC)
is
increasingly
becoming
prevalent
indication
for
transplantation.
existing
therapeutic
options
NAFLD,
NASH,
HCC
are
limited,
underscoring
urgent
need
innovative
treatment
strategies.
Insights
into
gene
expression,
particularly
RNA
modifications
such
N
6
methyladenosine
(m
A),
hold
promising
avenues
interventions.
These
play
integral
roles
in
metabolism
cellular
functions,
encompassing
entire
NAFLD-NASH-HCC
progression.
This
review
will
encompass
recent
insights
on
diverse
modifications,
including
m
A,
pseudouridine
(ψ),
1
-methyladenosine
5-methylcytidine
5
C)
across
various
species.
It
uncover
their
significance
crucial
aspects
steatosis,
inflammation,
fibrosis,
tumorigenesis.
Furthermore,
prospective
research
directions
implications
be
explored,
advancing
our
comprehensive
understanding
intricate
interconnected
nature
these
pathological
conditions.
Genes,
Год журнала:
2023,
Номер
14(8), С. 1653 - 1653
Опубликована: Авг. 19, 2023
Fatty
liver
disease
is
one
of
the
major
causes
morbidity
and
mortality
worldwide.
includes
non-alcoholic
fatty
(NAFLD)
steatohepatitis
(NASH),
now
replaced
by
a
consensus
group
as
metabolic
dysfunction-associated
steatotic
(MASLD).
While
excess
nutrition
obesity
are
contributors
to
liver,
underlying
mechanisms
remain
largely
unknown
therapeutic
interventions
limited.
Reversible
chemical
modifications
in
RNA
newly
recognized
critical
regulators
controlling
post-transcriptional
gene
expression.
Among
these
modifications,
N6-methyladenosine
(m6A)
most
abundant
regulates
transcript
abundance
disease.
Modulation
m6A
readers,
writers,
erasers
(RWE)
impacts
mRNA
processing,
translation,
nuclear
export,
localization,
degradation.
many
studies
focus
on
RWE
expression
human
pathologies,
limitations
technology
bioinformatic
methods
detect
present
challenges
understanding
epitranscriptomic
driving
progression.
In
this
review,
we
summarize
current
detecting
specific
genes
associated
with
Abstract
N6‐methyladenosine
(m6A)
is
the
most
abundant
modification
of
RNA
in
eukaryotic
cells.
Previous
studies
have
shown
that
m6A
pivotal
diverse
diseases
especially
cancer.
corelates
with
initiation,
progression,
resistance,
invasion,
and
metastasis
However,
despite
these
insights,
a
comprehensive
understanding
its
specific
roles
mechanisms
within
complex
landscape
cancer
still
elusive.
This
review
begins
by
outlining
key
regulatory
proteins
their
posttranslational
modifications
(PTMs),
as
well
role
chromatin
accessibility
transcriptional
activity
Additionally,
it
highlights
impact
progression
modulating
programmed
cell
death
affecting
tumor
microenvironment
through
various
cancer‐associated
immune
Furthermore,
discusses
how
microorganisms
can
induce
enduring
epigenetic
changes
oncogenic
effect
microorganism‐associated
cancers
altering
modifications.
Last,
delves
into
immunotherapy,
encompassing
therapy,
checkpoint
blockade,
cytokine
adoptive
transfer
direct
targeting
regulators.
Overall,
this
clarifies
multifaceted
explores
targeted
therapies
aimed
at
manipulating
modification,
aiming
to
advance
research
improve
patient
outcomes.
In
recent
years,
the
interplay
between
N6-methyladenosine
(m6A)
modifications
and
non-coding
RNAs
(ncRNAs)
has
emerged
as
a
pivotal
research
area,
owing
to
their
crucial
involvement
in
pathophysiological
mechanisms
underlying
various
diseases.
A
significant
hurdle
cancer
therapy
is
therapeutic
resistance,
which
frequently
contributes
adverse
patient
outcomes.
Recent
investigations
have
underscored
vital
role
that
interactions
m6A
ncRNAs
play
mediating
resistance
via
MAPK,
PI3K/Akt/mTOR,
Wnt/β-catenin,
HIPPO,
NF-κB
pathways.
This
review
elucidates
how
these
drive
tumor
by
modulating
By
dissecting
regulatory
dynamics
context
of
this
aims
deepen
understanding
m6A-ncRNA
interaction
identify
potential
targets
improve
treatment
efficacy.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12375 - 12375
Опубликована: Авг. 3, 2023
Ovarian
cancer
is
the
deadliest
gynecological
malignancy
of
reproductive
organs
in
United
States.
Cyclin-dependent
kinase
1
(CDK1)
an
important
cell
cycle
regulatory
protein
that
specifically
controls
G2/M
phase
transition
cycle.
RO-3306
a
selective,
ATP-competitive,
and
cell-permeable
CDK1
inhibitor
shows
potent
anti-tumor
activity
multiple
pre-clinical
models.
In
this
study,
we
investigated
effect
expression
on
prognosis
patients
with
ovarian
anti-tumorigenic
both
lines
genetically
engineered
mouse
model
high-grade
serous
(KpB
model).
147
epithelial
cancer,
overexpression
was
significantly
associated
poor
compared
low
group.
inhibited
cellular
proliferation,
induced
apoptosis,
caused
stress,
reduced
migration.
The
treatment
KpB
mice
for
four
weeks
showed
significant
decrease
tumor
weight
under
obese
lean
conditions
without
obvious
side
effects.
Overall,
our
results
demonstrate
inhibition
by
effectively
reduces
proliferation
growth,
providing
biological
evidence
future
clinical
trials
inhibitors
cancer.
