Food Science & Nutrition,
Год журнала:
2024,
Номер
12(11), С. 9238 - 9251
Опубликована: Сен. 30, 2024
Abstract
Resveratrol,
a
natural
compound
found
in
various
plants,
is
known
for
its
anti‐inflammatory,
antioxidant,
and
senescence‐delaying
properties.
RNA
N6‐methyladenosine
(m6A)
methylation
plays
crucial
role
oxidative
stress
premature
cellular
senescence
processes
closely
associated
with
age‐related
disorders.
However,
the
anti‐premature
via
m6A
mechanism
of
resveratrol
still
not
fully
understood.
In
this
study,
based
on
model
human
embryonic
lung
fibroblasts
(HEFs)
induced
by
hydrogen
peroxide
(H
2
O
),
widely
accepted
caused
stress,
we
explored
anti‐aging
regulatory
effects
at
level.
Our
data
suggested
that
significantly
delayed
increasing
cell
viability,
reducing
SA‐β‐gal
blue
staining
rate,
ROS
levels,
senescence‐associated
secretory
phenotypes
(SASP)
expression
HEFs.
Meanwhile,
increased
whole
methyltransferases
activity
overall
level
during
senescence.
Furthermore,
three
genes
CCND2
,
E2F1
GADD45B
have
been
identified
as
main
ones
regulating
resveratrol.
Specifically,
it
decreased
level,
cells.
study
provided
new
clues
exploring
application
field
aging.
Journal of Oral Pathology and Medicine,
Год журнала:
2024,
Номер
53(4), С. 266 - 274
Опубликована: Март 26, 2024
Inhibin
A
and
N6-methyladenosine
methylation
modifications
participate
in
oral
squamous
cell
carcinoma
development.
However,
the
modification
of
has
not
been
revealed.
This
study
reveals
a
key
gene
"Inhibin
A"
that
may
affect
tumorigenesis
its
molecular
mechanisms
on
methyltransferase
KIAA1429-mediated
modification.
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(2)
Опубликована: Дек. 18, 2024
Inflammatory
bowel
diseases
(IBDs),
which
encompasses
Crohn's
disease
and
ulcerative
colitis,
is
a
chronic
inflammatory
condition
associated
with
an
increased
risk
of
colorectal
cancer
(CRC).
Small
RNAs
have
been
linked
to
various
illnesses,
including
IBD
CRC.
These
small
also
serve
as
potential
biomarkers
for
these
diseases,
offering
cutting‑edge
approach
investigating
possible
treatments.
To
date,
treatments
involving
oral
nucleic
acid
usage
are
still
unachievable
due
the
instability
medications
in
gastrointestinal
tract
(GIT),
their
lack
ability
effectively
target
tissues
notable
adverse
effects.
However,
nanoparticle
or
exosome
delivery
systems
by
overcoming
GIT,
resulting
effective
outcome.
In
present
review,
biogenesis
(tRNA‑derived
RNA,
microRNA,
nucleolar
RNA
p‑element‑induced
wimpy
testis‑interacting
RNA),
roles
pathogenesis
CRC
well
application
diagnostic
prognostic
discussed.
European journal of medical research,
Год журнала:
2023,
Номер
28(1)
Опубликована: Ноя. 1, 2023
Abstract
Thyroid
cancer
(TC)
is
the
most
predominant
malignancy
of
endocrine
system,
with
steadily
growing
occurrence
and
morbidity
worldwide.
Although
diagnostic
therapeutic
methods
have
been
rapidly
developed
in
recent
years,
underlying
molecular
mechanisms
pathogenesis
TC
remain
enigmatic.
The
N6-methyladenosine(m6A)
RNA
modification
designed
to
impact
metabolism
further
gene
regulation.
This
process
intricately
regulated
by
a
variety
regulators,
such
as
methylases
demethylases.
Aberrant
m6A
regulators
expression
related
development
play
an
important
role
drug
resistance.
review
comprehensively
analyzes
effect
methylation
on
progression
potential
clinical
value
prognostic
markers
targets
this
disease.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Май 17, 2024
In
recent
years,
microRNAs
(miRNAs)
have
garnered
increasing
attention
for
their
potential
implications
in
cancer
pathogenesis,
functioning
either
as
oncogenes
or
tumor
suppressors.
Notably,
angiosarcoma,
along
with
various
other
cardiovascular
tumors
such
lipomas,
rhabdomyomas,
hemangiomas,
and
myxomas,
has
shown
variations
the
expression
of
specific
miRNA
subtypes.
A
substantial
body
evidence
underscores
pivotal
involvement
miRNAs
genesis
angiosarcoma
certain
tumors.
This
review
aims
to
delve
into
current
literature
on
prospective
applications
malignancies,
a
focus
angiosarcoma.
It
comprehensively
covers
diagnostic
methods,
prognostic
evaluations,
treatments
while
providing
recapitulation
angiosarcoma’s
risk
factors
molecular
an
emphasis
role
miRNAs.
These
insights
can
serve
groundwork
designing
randomized
control
trials,
ultimately
facilitating
translation
these
findings
clinical
applications.
Moving
forward,
it
is
imperative
studies
thoroughly
scrutinize
advantages
disadvantages
compared
approaches
Closing
knowledge
gaps
will
be
crucial
harnessing
full
realm
research.
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 5, 2024
Colorectal
cancer
(CRC)
is
one
of
the
most
common
non-cutaneous
malignancies,
causing
significant
mortality
and
a
substantial
burden.
This
study
aims
to
explore
role
KIAA1429
(also
known
as
vir-like
m6A
methyltransferase
associated
[VIRMA])
protein
in
radioresistance
CRC.
CRC
cells
radioresistant
cell
line
were
cultured,
expression
was
detected.
After
down-regulation
KIAA1429,
its
effect
on
ferroptosis
analyzed.
The
verified.
binding
relationship
among
long
non-coding
RNA
endogenous
Bornavirus-like
nucleoprotein
3,
pseudogene
(lncRNA
EBLN3P),
microRNA
(miR)-153-3p,
lncRNA
EBLN3P
highly
expressed
CRC,
while
miR-153-3p
poorly
expressed.
further
increased/decreased
cells.
knockdown
decreased
survival
rate
after
X-ray
irradiation
increased
gamma
H2A
histone
family
member
X
(γ-H2AX),
ferroptosis,
oxidative
stress.
A
inhibitor
alleviated
inhibitory
radioresistance.
KIAA1429-mediated
modification
up-regulated
EBLN3P,
by
competitively
miR-153-3p.
silencing
or
overexpression
attenuated
promotion
inhibition
induced
knockdown.
Overall,
expression,
miR-153-3p,
thus
reducing
increasing
Journal of Virology,
Год журнала:
2024,
Номер
99(1)
Опубликована: Ноя. 21, 2024
N6-methyladenosine
(m6A)
is
a
common
and
dynamic
epitranscriptomic
modification
in
eukaryotic
RNAs,
affecting
stability,
splicing,
translation,
degradation.
Recent
technological
advancements
have
revealed
the
complex
nature
of
m6A
modifications,
highlighting
their
importance
plant
animal
species.
The
reversible
process,
with
"writers"
depositing
methylation,
"erasers"
demethylating
it,
"reader"
proteins
recognizing
executing
various
biological
functions.
Studying
relationship
between
methylation
viral
infection
crucial.
Animal
viruses,
including
retroviruses,
RNA
DNA
often
employ
host's
machinery
to
replicate
or
avoid
immune
responses.
In
host
methyltransferases
demethylases
can
stabilize
degrade
RNA,
depending
on
virus-host
interaction.
Additionally,
infections
modify
machinery,
impacting
life
cycle.
This
review
examines
role
modifications
pathogenesis,
focussing
viruses
infecting
crops
like
alfalfa,
turnip,
wheat,
rice,
potato.
Understanding
interactions
aid
studying
disease
development
discovering
novel
antiviral
targets
for
crop
protection.
this
review,
we
summarize
current
information
biology,
its
function
plant-virus
interactions.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Июль 24, 2023
Tumor
Necrosis
Factor-alpha
(TNF-α)
is
ubiquitous
in
the
human
body
and
plays
a
significant
role
various
physiological
pathological
processes.
However,
TNF-α-induced
diseases
remain
poorly
understood
with
limited
efficacy
due
to
intricate
nature
of
their
mechanisms.
N6-methyladenosine
(m6A)
methylation,
prevalent
type
epigenetic
modification
mRNA,
primarily
occurs
at
post-transcriptional
level
involved
intranuclear
extranuclear
mRNA
metabolism.
Evidence
suggests
that
m6A
methylation
participates
signaling
pathways
associated
TNF-α.
This
review
summarizes
involvement
TNF-α
regulators
diseases,
investigates
impact
on
puts
forth
potential
therapeutic
targets
for
treating
diseases.
Medicine,
Год журнала:
2023,
Номер
102(47), С. e36394 - e36394
Опубликована: Ноя. 24, 2023
Colorectal
cancer
is
the
third
most
common
malignant
tumor
worldwide,
causing
serious
harm
to
human
health.
Epigenetic
modification,
especially
RNA
methylation
plays
a
critical
role
in
occurrence
and
development
of
colorectal
via
post-transcriptional
regulation
mRNA
non-coding
expression.
Among
these,
N6-methyladenosine
(m
6
A)
chemical
modification
mammals,
which
an
important
progress
cancer,
including
cancer.
m
A
dynamic
reversible
process
mainly
regulated
by
methyltransferase
(“writers”),
demethylases
(“erasers”),
binding
proteins
(“readers”).
Herein,
we
reviewed
recent
advances
focused
on
factors
affecting
modification.
Furthermore,
discussed
clinical
application
modifications
for
diagnosis,
prognosis,
treatment
provided
guides
practice.
regulators
play
significant
roles
regulating
stability
translation
mRNAs,
maturation
miRNAs,
function
lncRNAs.
can
biological
through
A-dependent
manner
or
A-independent
manner.
Multiplies
internal
factors,
miRNAs
lncRNAs,
external
also
regulate
completing
with
base
complement
manner,
expression
mutating
site.
modificantion
are
diagnostic
prognostic
markers
CRC.
Therefore,
may
be
potential
therapeutic
target
CRC
future.
