RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells DOI Creative Commons

Xinyu Zhang,

Chenyu Zhu,

Luyun Zhang

и другие.

Food Science & Nutrition, Год журнала: 2024, Номер 12(11), С. 9238 - 9251

Опубликована: Сен. 30, 2024

Abstract Resveratrol, a natural compound found in various plants, is known for its anti‐inflammatory, antioxidant, and senescence‐delaying properties. RNA N6‐methyladenosine (m6A) methylation plays crucial role oxidative stress premature cellular senescence processes closely associated with age‐related disorders. However, the anti‐premature via m6A mechanism of resveratrol still not fully understood. In this study, based on model human embryonic lung fibroblasts (HEFs) induced by hydrogen peroxide (H 2 O ), widely accepted caused stress, we explored anti‐aging regulatory effects at level. Our data suggested that significantly delayed increasing cell viability, reducing SA‐β‐gal blue staining rate, ROS levels, senescence‐associated secretory phenotypes (SASP) expression HEFs. Meanwhile, increased whole methyltransferases activity overall level during senescence. Furthermore, three genes CCND2 , E2F1 GADD45B have been identified as main ones regulating resveratrol. Specifically, it decreased level, cells. study provided new clues exploring application field aging.

Язык: Английский

Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429‐mediated m6A modification DOI
Xiaoqing Chen,

Ruoying Fan

Journal of Oral Pathology and Medicine, Год журнала: 2024, Номер 53(4), С. 266 - 274

Опубликована: Март 26, 2024

Inhibin A and N6-methyladenosine methylation modifications participate in oral squamous cell carcinoma development. However, the modification of has not been revealed. This study reveals a key gene "Inhibin A" that may affect tumorigenesis its molecular mechanisms on methyltransferase KIAA1429-mediated modification.

Язык: Английский

Процитировано

2

Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review) DOI Creative Commons
Wei Qiu,

Francis Atim Akanyibah,

Yuxuan Xia

и другие.

International Journal of Molecular Medicine, Год журнала: 2024, Номер 55(2)

Опубликована: Дек. 18, 2024

Inflammatory bowel diseases (IBDs), which encompasses Crohn's disease and ulcerative colitis, is a chronic inflammatory condition associated with an increased risk of colorectal cancer (CRC). Small RNAs have been linked to various illnesses, including IBD CRC. These small also serve as potential biomarkers for these diseases, offering cutting‑edge approach investigating possible treatments. To date, treatments involving oral nucleic acid usage are still unachievable due the instability medications in gastrointestinal tract (GIT), their lack ability effectively target tissues notable adverse effects. However, nanoparticle or exosome delivery systems by overcoming GIT, resulting effective outcome. In present review, biogenesis (tRNA‑derived RNA, microRNA, nucleolar RNA p‑element‑induced wimpy testis‑interacting RNA), roles pathogenesis CRC well application diagnostic prognostic discussed.

Язык: Английский

Процитировано

2

The emerging roles of N6-methyladenosine RNA modifications in thyroid cancer DOI Creative Commons
Xiaoxin Xu, Jiayao Zhao, Mingyue Yang

и другие.

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Ноя. 1, 2023

Abstract Thyroid cancer (TC) is the most predominant malignancy of endocrine system, with steadily growing occurrence and morbidity worldwide. Although diagnostic therapeutic methods have been rapidly developed in recent years, underlying molecular mechanisms pathogenesis TC remain enigmatic. The N6-methyladenosine(m6A) RNA modification designed to impact metabolism further gene regulation. This process intricately regulated by a variety regulators, such as methylases demethylases. Aberrant m6A regulators expression related development play an important role drug resistance. review comprehensively analyzes effect methylation on progression potential clinical value prognostic markers targets this disease.

Язык: Английский

Процитировано

4

MicroRNAs and angiosarcoma: are there promising reports? DOI Creative Commons
Amir Modarresi Chahardehi, Arya Afrooghe,

Nikoo Emtiazi

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 17, 2024

In recent years, microRNAs (miRNAs) have garnered increasing attention for their potential implications in cancer pathogenesis, functioning either as oncogenes or tumor suppressors. Notably, angiosarcoma, along with various other cardiovascular tumors such lipomas, rhabdomyomas, hemangiomas, and myxomas, has shown variations the expression of specific miRNA subtypes. A substantial body evidence underscores pivotal involvement miRNAs genesis angiosarcoma certain tumors. This review aims to delve into current literature on prospective applications malignancies, a focus angiosarcoma. It comprehensively covers diagnostic methods, prognostic evaluations, treatments while providing recapitulation angiosarcoma’s risk factors molecular an emphasis role miRNAs. These insights can serve groundwork designing randomized control trials, ultimately facilitating translation these findings clinical applications. Moving forward, it is imperative studies thoroughly scrutinize advantages disadvantages compared approaches Closing knowledge gaps will be crucial harnessing full realm research.

Язык: Английский

Процитировано

1

Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer DOI Creative Commons
Hao Chen, Peipei Zhu,

Dan Zhu

и другие.

Biomolecules and Biomedicine, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Colorectal cancer (CRC) is one of the most common non-cutaneous malignancies, causing significant mortality and a substantial burden. This study aims to explore role KIAA1429 (also known as vir-like m6A methyltransferase associated [VIRMA]) protein in radioresistance CRC. CRC cells radioresistant cell line were cultured, expression was detected. After down-regulation KIAA1429, its effect on ferroptosis analyzed. The verified. binding relationship among long non-coding RNA endogenous Bornavirus-like nucleoprotein 3, pseudogene (lncRNA EBLN3P), microRNA (miR)-153-3p, lncRNA EBLN3P highly expressed CRC, while miR-153-3p poorly expressed. further increased/decreased cells. knockdown decreased survival rate after X-ray irradiation increased gamma H2A histone family member X (γ-H2AX), ferroptosis, oxidative stress. A inhibitor alleviated inhibitory radioresistance. KIAA1429-mediated modification up-regulated EBLN3P, by competitively miR-153-3p. silencing or overexpression attenuated promotion inhibition induced knockdown. Overall, expression, miR-153-3p, thus reducing increasing

Язык: Английский

Процитировано

1

Histone methylation and acetylation in cancer: mechanism, progression, and targets DOI
Su Bu, Ting Ye, Hang Gao

и другие.

ONCOLOGIE, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

Процитировано

1

Mechanism of the KIAA1429/KLF1/PD-L1 Axis in Regulating Immune Escape in Non-small Cell Lung Cancer DOI
Rui Geng,

Mingmin Ren,

Yuhui Ma

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Язык: Английский

Процитировано

1

Insights into the role of N6-methyladenosine (m6A) in plant-virus interactions DOI Creative Commons
Nicola Secco, Arsheed H. Sheikh, Heribert Hirt

и другие.

Journal of Virology, Год журнала: 2024, Номер 99(1)

Опубликована: Ноя. 21, 2024

N6-methyladenosine (m6A) is a common and dynamic epitranscriptomic modification in eukaryotic RNAs, affecting stability, splicing, translation, degradation. Recent technological advancements have revealed the complex nature of m6A modifications, highlighting their importance plant animal species. The reversible process, with "writers" depositing methylation, "erasers" demethylating it, "reader" proteins recognizing executing various biological functions. Studying relationship between methylation viral infection crucial. Animal viruses, including retroviruses, RNA DNA often employ host's machinery to replicate or avoid immune responses. In host methyltransferases demethylases can stabilize degrade RNA, depending on virus-host interaction. Additionally, infections modify machinery, impacting life cycle. This review examines role modifications pathogenesis, focussing viruses infecting crops like alfalfa, turnip, wheat, rice, potato. Understanding interactions aid studying disease development discovering novel antiviral targets for crop protection. this review, we summarize current information biology, its function plant-virus interactions.

Язык: Английский

Процитировано

1

Role of TNF-α-induced m6A RNA methylation in diseases: a comprehensive review DOI Creative Commons

Youlin Wang,

Jing Liu, Yongchen Wang

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Июль 24, 2023

Tumor Necrosis Factor-alpha (TNF-α) is ubiquitous in the human body and plays a significant role various physiological pathological processes. However, TNF-α-induced diseases remain poorly understood with limited efficacy due to intricate nature of their mechanisms. N6-methyladenosine (m6A) methylation, prevalent type epigenetic modification mRNA, primarily occurs at post-transcriptional level involved intranuclear extranuclear mRNA metabolism. Evidence suggests that m6A methylation participates signaling pathways associated TNF-α. This review summarizes involvement TNF-α regulators diseases, investigates impact on puts forth potential therapeutic targets for treating diseases.

Язык: Английский

Процитировано

3

Research progress of N6-methyladenosine in colorectal cancer: A review DOI Creative Commons
Yu Lin,

Hongjun Shi,

Lianping Wu

и другие.

Medicine, Год журнала: 2023, Номер 102(47), С. e36394 - e36394

Опубликована: Ноя. 24, 2023

Colorectal cancer is the third most common malignant tumor worldwide, causing serious harm to human health. Epigenetic modification, especially RNA methylation plays a critical role in occurrence and development of colorectal via post-transcriptional regulation mRNA non-coding expression. Among these, N6-methyladenosine (m 6 A) chemical modification mammals, which an important progress cancer, including cancer. m A dynamic reversible process mainly regulated by methyltransferase (“writers”), demethylases (“erasers”), binding proteins (“readers”). Herein, we reviewed recent advances focused on factors affecting modification. Furthermore, discussed clinical application modifications for diagnosis, prognosis, treatment provided guides practice. regulators play significant roles regulating stability translation mRNAs, maturation miRNAs, function lncRNAs. can biological through A-dependent manner or A-independent manner. Multiplies internal factors, miRNAs lncRNAs, external also regulate completing with base complement manner, expression mutating site. modificantion are diagnostic prognostic markers CRC. Therefore, may be potential therapeutic target CRC future.

Язык: Английский

Процитировано

3